Parallel laboratory evolution and rational debugging reveal genomic plasticity to S. cerevisiae synthetic chromosome XIV defects

Synthetic chromosome engineering is a complex process due to the need to identify and repair growth defects and deal with combinatorial gene essentiality when rearranging chromosomes. To alleviate these issues, we have demonstrated novel approaches for repairing and rearranging synthetic Saccharomyc...

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Veröffentlicht in:	Cell genomics 2023-11, Vol.3 (11), p.100379-100379, Article 100379
Hauptverfasser:	Williams, Thomas C., Kroukamp, Heinrich, Xu, Xin, Wightman, Elizabeth L.I., Llorente, Briardo, Borneman, Anthony R., Carpenter, Alexander C., Van Wyk, Niel, Meier, Felix, Collier, Thomas R.V., Espinosa, Monica I., Daniel, Elizabeth L., Walker, Roy S.K., Cai, Yizhi, Nevalainen, Helena K.M., Curach, Natalie C., Deveson, Ira W., Mercer, Timothy R., Johnson, Daniel L., Mitchell, Leslie A., Bader, Joel S., Stracquadanio, Giovanni, Boeke, Jef D., Goold, Hugh D., Pretorius, Isak S., Paulsen, Ian T.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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