Mutual regulation of TGFβ-induced oncogenic EMT, cell cycle progression and the DDR

TGFβ signaling and the DNA damage response (DDR) are two cellular toolboxes with a strong impact on cancer biology. While TGFβ as a pleiotropic cytokine affects essentially all hallmarks of cancer, the multifunctional DDR mostly orchestrates cell cycle progression, DNA repair, chromatin remodeling a...

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Veröffentlicht in:	Seminars in cancer biology 2023-12, Vol.97, p.86-103
Hauptverfasser:	Schuhwerk, Harald, Brabletz, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Cycle - genetics Epithelial-Mesenchymal Transition - genetics Humans Neoplasms - genetics Signal Transduction Transcription Factors Transforming Growth Factor beta - metabolism
Online-Zugang:	Volltext
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