CBD lengthens sleep but shortens ripples and leads to intact simple but worse cumulative memory
Cannabidiol (CBD) is on the rise as over-the-counter medication to treat sleep disturbances, anxiety, pain, and epilepsy due to its action on the excitatory/inhibitory balance in the brain. However, it remains unclear if CBD also leads to adverse effects on memory via changes of sleep macro- and mic...
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Veröffentlicht in: | iScience 2023-11, Vol.26 (11), p.108327-108327, Article 108327 |
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creator | Samanta, Anumita Aleman-Zapata, Adrian Agarwal, Kopal Özsezer, Pelin Alonso, Alejandra van der Meij, Jacqueline Rayan, Abdelrahman Navarro-Lobato, Irene Genzel, Lisa |
description | Cannabidiol (CBD) is on the rise as over-the-counter medication to treat sleep disturbances, anxiety, pain, and epilepsy due to its action on the excitatory/inhibitory balance in the brain. However, it remains unclear if CBD also leads to adverse effects on memory via changes of sleep macro- and microarchitecture. To investigate the effect of CBD on sleep and memory consolidation, we performed two experiments using the object space task testing for both simple and cumulative memory in rats. We show that oral CBD administration extended the sleep period but changed the properties of rest and non-REM sleep oscillations (delta, spindle, ripples). Specifically, CBD also led to less long (>100 ms) ripples and, consequently, worse cumulative memory consolidation. In contrast, simple memories were not affected. In sum, we can confirm the beneficial effect of CBD on sleep; however, this comes with changes in oscillations that negatively impact memory consolidation.
[Display omitted]
•CBD lengthens non-REM sleep•CBD shortens ripples•CBD negatively impacts cumulative memory performance•CBD leaves simple memory intact
Pharmacology; Cognitive neuroscience |
doi_str_mv | 10.1016/j.isci.2023.108327 |
format | Article |
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[Display omitted]
•CBD lengthens non-REM sleep•CBD shortens ripples•CBD negatively impacts cumulative memory performance•CBD leaves simple memory intact
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[Display omitted]
•CBD lengthens non-REM sleep•CBD shortens ripples•CBD negatively impacts cumulative memory performance•CBD leaves simple memory intact
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[Display omitted]
•CBD lengthens non-REM sleep•CBD shortens ripples•CBD negatively impacts cumulative memory performance•CBD leaves simple memory intact
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source | Directory of Open Access Journals; PubMed (Medline); Free E-Journal (出版社公開部分のみ); Alma/SFX Local Collection |
subjects | Cognitive neuroscience Pharmacology |
title | CBD lengthens sleep but shortens ripples and leads to intact simple but worse cumulative memory |
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