Neutrophil Virucidal Activity Against SARS-CoV-2 Is Mediated by Neutrophil Extracellular Traps

Inflammation in the lungs and other vital organs in COVID-19 is characterized by the presence of neutrophils and a high concentration of neutrophil extracellular traps (NETs), which seems to mediate host tissue damage. However, it is not known whether NETs could have virucidal activity against SARS-...

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Veröffentlicht in:	The Journal of infectious diseases 2024-05, Vol.229 (5), p.1352-1365
Hauptverfasser:	Dos Ramos Almeida, Cícero José Luíz, Veras, Flávio Protásio, Paiva, Isadora Marques, Schneider, Ayda Henriques, da Costa Silva, Juliana, Gomes, Giovanni Freitas, Costa, Victor Ferreira, Silva, Bruna Manuella Souza, Caetite, Diego Brito, Silva, Camila Meirelles Souza, Salina, Ana Caroline Guerta, Martins, Ronaldo, Bonilha, Caio Santos, Cunha, Larissa Dias, Jamur, Maria Célia, da Silva, Luís Lamberti Pinto, Arruda, Eurico, Zamboni, Dario Simões, Louzada-Junior, Paulo, de Oliveira, Renê Donizeti Ribeiro, Alves-Filho, José Carlos, Cunha, Thiago Mattar, de Queiroz Cunha, Fernando
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme 2 - metabolism Animals COVID-19 - immunology COVID-19 - virology Deoxyribonuclease I - metabolism Epithelial Cells - virology Extracellular Traps Humans Mice Mice, Transgenic Neutrophils - immunology SARS-CoV-2 Viral Load Virus Replication - drug effects
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