Interactive Effects of Empagliflozin and Hyperglycemia on Urinary Amino Acids in Individuals With Type 1 Diabetes

Optimizing energy use in the kidney is critical for normal kidney function. Here, we investigate the effect of hyperglycemia and sodium-glucose cotransporter 2 (SGLT2) inhibition on urinary amino acid excretion in individuals with type 1 diabetes (T1D). The open-label ATIRMA trial assessed the impac...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2024-03, Vol.73 (3), p.401-411
Hauptverfasser:	Kugathasan, Luxcia, Sridhar, Vikas S, Lovblom, Leif Erik, Matta, Shane, Saliba, Afaf, Debnath, Subrata, AlAkwaa, Fadhl M, Nair, Viji, Bjornstad, Petter, Kretzler, Matthias, Perkins, Bruce A, Sharma, Kumar, Cherney, David Z I
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Amino acids Amino Acids - metabolism Antidiabetics Benzhydryl Compounds Biosynthesis Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - drug therapy Energy metabolism Glucosides Histidine Humans Hyperglycemia Hyperglycemia - drug therapy Isoleucine Leucine Metabolic pathways Metabolites Metabolomics Nicotinic acid Principal components analysis RNA, Transfer Sodium-glucose cotransporter Sodium-Glucose Transporter 2 Transfer RNA tRNA Ile tRNA Leu tRNA Val Tryptophan Valine Young Adult Young adults
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