Clinical and histological wound healing patterns of collagen‐based substitutes: An experimental randomized controlled trial in standardized palatal defects in humans
Aim To evaluate the progression of wound healing of standardized palatal defects in groups using three different collagen‐based wound dressings and a control group, in terms of wound closure, pain perception and descriptive histology. Materials and Methods Twenty participants were enrolled in this e...
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| Veröffentlicht in: | Journal of clinical periodontology 2024-03, Vol.51 (3), p.319-329 |
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| creator | Bienz, Stefan P. Gadzo, Naida Zuercher, Anina N. Wiedemeier, Daniel Jung, Ronald E. Thoma, Daniel S. |
| description | Aim
To evaluate the progression of wound healing of standardized palatal defects in groups using three different collagen‐based wound dressings and a control group, in terms of wound closure, pain perception and descriptive histology.
Materials and Methods
Twenty participants were enrolled in this experimental study, in whom four palatal defects were created. The defects (6 mm diameter, 3 mm depth) were randomly assigned to one of four treatment modalities: C (control), MG (Mucograft®), MD (mucoderm®) and FG (Fibro‐Gide®). Photographs were taken, and pain assessment was performed before and after treatment and at 5, 7, 9, 12, 14 and 16 days after surgery. All participants wore a palatal splint for a duration of 16 days.
Results
All groups achieved complete wound closure at 14 days. The percentage of the remaining open wound on day 7 amounted to 49.3% (C; interquartile range [IQR]: 22.6), 70.1% (FG; IQR: 20.7), 56.8% (MD; IQR: 26.3) and 62.2% (MG; IQR: 34.4). Statistically significant differences were found between FG and C (p =.01) and between MD and FG (p =.04). None of the participants rated pain higher than 4 out of 10 during the entire study period.
Conclusions
Collagen‐based wound dressings provide coverage of open defects, albeit without acceleration of wound closure or reduction of pain. FG (which is not intended for open oral wounds) showed slower wound closure compared to C and MD. |
| doi_str_mv | 10.1111/jcpe.13903 |
| format | Article |
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To evaluate the progression of wound healing of standardized palatal defects in groups using three different collagen‐based wound dressings and a control group, in terms of wound closure, pain perception and descriptive histology.
Materials and Methods
Twenty participants were enrolled in this experimental study, in whom four palatal defects were created. The defects (6 mm diameter, 3 mm depth) were randomly assigned to one of four treatment modalities: C (control), MG (Mucograft®), MD (mucoderm®) and FG (Fibro‐Gide®). Photographs were taken, and pain assessment was performed before and after treatment and at 5, 7, 9, 12, 14 and 16 days after surgery. All participants wore a palatal splint for a duration of 16 days.
Results
All groups achieved complete wound closure at 14 days. The percentage of the remaining open wound on day 7 amounted to 49.3% (C; interquartile range [IQR]: 22.6), 70.1% (FG; IQR: 20.7), 56.8% (MD; IQR: 26.3) and 62.2% (MG; IQR: 34.4). Statistically significant differences were found between FG and C (p =.01) and between MD and FG (p =.04). None of the participants rated pain higher than 4 out of 10 during the entire study period.
Conclusions
Collagen‐based wound dressings provide coverage of open defects, albeit without acceleration of wound closure or reduction of pain. FG (which is not intended for open oral wounds) showed slower wound closure compared to C and MD.</description><identifier>ISSN: 0303-6979</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/jcpe.13903</identifier><identifier>PMID: 38017650</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Clinical outcomes ; Collagen ; histology ; Medical dressings ; Pain management ; Pain perception ; patient‐reported outcome measures ; profilometric analysis ; soft‐tissue substitutes ; Statistical analysis ; Wound healing</subject><ispartof>Journal of clinical periodontology, 2024-03, Vol.51 (3), p.319-329</ispartof><rights>2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3163-cf32082d6a871b1d27e3a26a1759fba620a913a1dceac504ada899c63bedfd9d3</cites><orcidid>0000-0002-5262-6756 ; 0000-0002-1764-7447 ; 0000-0003-2055-1320 ; 0000-0001-8997-700X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjcpe.13903$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjcpe.13903$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38017650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bienz, Stefan P.</creatorcontrib><creatorcontrib>Gadzo, Naida</creatorcontrib><creatorcontrib>Zuercher, Anina N.</creatorcontrib><creatorcontrib>Wiedemeier, Daniel</creatorcontrib><creatorcontrib>Jung, Ronald E.</creatorcontrib><creatorcontrib>Thoma, Daniel S.</creatorcontrib><title>Clinical and histological wound healing patterns of collagen‐based substitutes: An experimental randomized controlled trial in standardized palatal defects in humans</title><title>Journal of clinical periodontology</title><addtitle>J Clin Periodontol</addtitle><description>Aim
To evaluate the progression of wound healing of standardized palatal defects in groups using three different collagen‐based wound dressings and a control group, in terms of wound closure, pain perception and descriptive histology.
Materials and Methods
Twenty participants were enrolled in this experimental study, in whom four palatal defects were created. The defects (6 mm diameter, 3 mm depth) were randomly assigned to one of four treatment modalities: C (control), MG (Mucograft®), MD (mucoderm®) and FG (Fibro‐Gide®). Photographs were taken, and pain assessment was performed before and after treatment and at 5, 7, 9, 12, 14 and 16 days after surgery. All participants wore a palatal splint for a duration of 16 days.
Results
All groups achieved complete wound closure at 14 days. The percentage of the remaining open wound on day 7 amounted to 49.3% (C; interquartile range [IQR]: 22.6), 70.1% (FG; IQR: 20.7), 56.8% (MD; IQR: 26.3) and 62.2% (MG; IQR: 34.4). Statistically significant differences were found between FG and C (p =.01) and between MD and FG (p =.04). None of the participants rated pain higher than 4 out of 10 during the entire study period.
Conclusions
Collagen‐based wound dressings provide coverage of open defects, albeit without acceleration of wound closure or reduction of pain. FG (which is not intended for open oral wounds) showed slower wound closure compared to C and MD.</description><subject>Clinical outcomes</subject><subject>Collagen</subject><subject>histology</subject><subject>Medical dressings</subject><subject>Pain management</subject><subject>Pain perception</subject><subject>patient‐reported outcome measures</subject><subject>profilometric analysis</subject><subject>soft‐tissue substitutes</subject><subject>Statistical analysis</subject><subject>Wound healing</subject><issn>0303-6979</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kcFu1DAQhi0EokvhwgOgSFwqpJSxTZI1t2pVCqgSHEDiFk3sydarxA62o1JOPELfgvfiSXB2CwcO-OLR_N_8Gvtn7CmHU57Py52e6JRLBfIeW_EaoISKf7nPViBBlrVq1BF7FOMOgDdSyofsSK5zWVewYj83g3VW41CgM8WVjckPfrtvXPt5aRFmYltMmBIFFwvfF9oPA27J_fpx22EkU8S5i8mmOVF8XZy5gr5NFOxILmWfkJ39aL9nTnuXQh7OZQo2a9YVMWUdg9kDEw64zBjqSae46FfziC4-Zg96HCI9ubuP2ec35582b8vLDxfvNmeXpZa8lqXupYC1MDWuG95xIxqSKGrkTaX6DmsBqLhEbjShruAVGlwrpWvZkemNMvKYnRx8p-C_zhRTO9qoKb_XkZ9jK9aqEjUogIw-_wfd-Tm4vF0rlGhAgFQiUy8OlA4-xkB9O-WfwXDTcmiX-NolvnYfX4af3VnO3UjmL_onrwzwA3BtB7r5j1X7fvPx_GD6G4zfqqM</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Bienz, Stefan P.</creator><creator>Gadzo, Naida</creator><creator>Zuercher, Anina N.</creator><creator>Wiedemeier, Daniel</creator><creator>Jung, Ronald E.</creator><creator>Thoma, Daniel S.</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5262-6756</orcidid><orcidid>https://orcid.org/0000-0002-1764-7447</orcidid><orcidid>https://orcid.org/0000-0003-2055-1320</orcidid><orcidid>https://orcid.org/0000-0001-8997-700X</orcidid></search><sort><creationdate>202403</creationdate><title>Clinical and histological wound healing patterns of collagen‐based substitutes: An experimental randomized controlled trial in standardized palatal defects in humans</title><author>Bienz, Stefan P. ; Gadzo, Naida ; Zuercher, Anina N. ; Wiedemeier, Daniel ; Jung, Ronald E. ; Thoma, Daniel S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3163-cf32082d6a871b1d27e3a26a1759fba620a913a1dceac504ada899c63bedfd9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Clinical outcomes</topic><topic>Collagen</topic><topic>histology</topic><topic>Medical dressings</topic><topic>Pain management</topic><topic>Pain perception</topic><topic>patient‐reported outcome measures</topic><topic>profilometric analysis</topic><topic>soft‐tissue substitutes</topic><topic>Statistical analysis</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bienz, Stefan P.</creatorcontrib><creatorcontrib>Gadzo, Naida</creatorcontrib><creatorcontrib>Zuercher, Anina N.</creatorcontrib><creatorcontrib>Wiedemeier, Daniel</creatorcontrib><creatorcontrib>Jung, Ronald E.</creatorcontrib><creatorcontrib>Thoma, Daniel S.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bienz, Stefan P.</au><au>Gadzo, Naida</au><au>Zuercher, Anina N.</au><au>Wiedemeier, Daniel</au><au>Jung, Ronald E.</au><au>Thoma, Daniel S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and histological wound healing patterns of collagen‐based substitutes: An experimental randomized controlled trial in standardized palatal defects in humans</atitle><jtitle>Journal of clinical periodontology</jtitle><addtitle>J Clin Periodontol</addtitle><date>2024-03</date><risdate>2024</risdate><volume>51</volume><issue>3</issue><spage>319</spage><epage>329</epage><pages>319-329</pages><issn>0303-6979</issn><eissn>1600-051X</eissn><abstract>Aim
To evaluate the progression of wound healing of standardized palatal defects in groups using three different collagen‐based wound dressings and a control group, in terms of wound closure, pain perception and descriptive histology.
Materials and Methods
Twenty participants were enrolled in this experimental study, in whom four palatal defects were created. The defects (6 mm diameter, 3 mm depth) were randomly assigned to one of four treatment modalities: C (control), MG (Mucograft®), MD (mucoderm®) and FG (Fibro‐Gide®). Photographs were taken, and pain assessment was performed before and after treatment and at 5, 7, 9, 12, 14 and 16 days after surgery. All participants wore a palatal splint for a duration of 16 days.
Results
All groups achieved complete wound closure at 14 days. The percentage of the remaining open wound on day 7 amounted to 49.3% (C; interquartile range [IQR]: 22.6), 70.1% (FG; IQR: 20.7), 56.8% (MD; IQR: 26.3) and 62.2% (MG; IQR: 34.4). Statistically significant differences were found between FG and C (p =.01) and between MD and FG (p =.04). None of the participants rated pain higher than 4 out of 10 during the entire study period.
Conclusions
Collagen‐based wound dressings provide coverage of open defects, albeit without acceleration of wound closure or reduction of pain. FG (which is not intended for open oral wounds) showed slower wound closure compared to C and MD.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>38017650</pmid><doi>10.1111/jcpe.13903</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5262-6756</orcidid><orcidid>https://orcid.org/0000-0002-1764-7447</orcidid><orcidid>https://orcid.org/0000-0003-2055-1320</orcidid><orcidid>https://orcid.org/0000-0001-8997-700X</orcidid></addata></record> |
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| source | Wiley Online Library All Journals |
| subjects | Clinical outcomes Collagen histology Medical dressings Pain management Pain perception patient‐reported outcome measures profilometric analysis soft‐tissue substitutes Statistical analysis Wound healing |
| title | Clinical and histological wound healing patterns of collagen‐based substitutes: An experimental randomized controlled trial in standardized palatal defects in humans |
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