Discovery of regulatory motifs in 5' untranslated regions using interpretable multi-task learning models

The sequence in the 5' untranslated regions (UTRs) is known to affect mRNA translation rates. However, the underlying regulatory grammar remains elusive. Here, we propose MTtrans, a multi-task translation rate predictor capable of learning common sequence patterns from datasets across various e...

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Veröffentlicht in:	Cell systems 2023-12, Vol.14 (12), p.1103-1112.e6
Hauptverfasser:	Zheng, Weizhong, Fong, John H C, Wan, Yuk Kei, Chu, Athena H Y, Huang, Yuanhua, Wong, Alan S L, Ho, Joshua W K
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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