Intrinsic plasticity of Purkinje cell serves homeostatic regulation of fear memory
Two forms of plasticity, synaptic and intrinsic, are neural substrates for learning and memory. Abnormalities in homeostatic plasticity cause severe neuropsychiatric diseases, such as schizophrenia and autism. This suggests that the balance between synaptic transmission and intrinsic excitability is...
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| Veröffentlicht in: | Molecular psychiatry 2024-02, Vol.29 (2), p.247-256 |
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| creator | Lee, Jaegeon Kim, Seung Ha Jang, Dong Cheol Jang, Mirae Bak, Myeong Seong Shim, Hyun Geun Lee, Yong-Seok Kim, Sang Jeong |
| description | Two forms of plasticity, synaptic and intrinsic, are neural substrates for learning and memory. Abnormalities in homeostatic plasticity cause severe neuropsychiatric diseases, such as schizophrenia and autism. This suggests that the balance between synaptic transmission and intrinsic excitability is important for physiological function in the brain. Despite the established role of synaptic plasticity between parallel fiber (PF) and Purkinje cell (PC) in fear memory, its relationship with intrinsic plasticity is not well understood. Here, patch clamp recording revealed depression of intrinsic excitability in PC following auditory fear conditioning (AFC). Depressed excitability balanced long-term potentiation of PF-PC synapse to serve homeostatic regulation of PF-evoked PC firing. We then optogenetically manipulated PC excitability during the early consolidation period resulting in bidirectional regulation of fear memory. Fear conditioning-induced synaptic plasticity was also regulated following optogenetic manipulation. These results propose intrinsic plasticity in PC as a novel mechanism of fear memory and elucidate that decreased intrinsic excitability in PC counterbalances PF-PC synaptic potentiation to maintain fear memory in a normal range. |
| doi_str_mv | 10.1038/s41380-023-02320-8 |
| format | Article |
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| subjects | 631/378 631/443 9/74 Animals Autism Behavioral Sciences Biological Psychology Conditioning, Classical - physiology Excitability Fear - physiology Fear conditioning Hibernation Homeostasis - physiology Homeostatic plasticity Long-term potentiation Long-Term Potentiation - physiology Male Medicine Medicine & Public Health Memory - physiology Mental disorders Mice Mice, Inbred C57BL Neuronal Plasticity - physiology Neuroplasticity Neurosciences Optogenetics - methods Patch-Clamp Techniques Pharmacotherapy Psychiatry Purkinje Cells - physiology Schizophrenia Synapses Synapses - physiology Synaptic plasticity Synaptic transmission Synaptic Transmission - physiology |
| title | Intrinsic plasticity of Purkinje cell serves homeostatic regulation of fear memory |
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