Vincristine exposure impairs mouse oocyte quality by inducing spindle defects and early apoptosis

Vincristine (VCR) is a microtubule‐destabilizing chemotherapeutic agent commonly administered for the treatment of cancers in patients, which can induce severe side effects including neurotoxicity. In context of the effects on female fertility, ovarian toxicity has been found in patients and mice mo...

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Veröffentlicht in:	IUBMB life 2024-06, Vol.76 (6), p.345-356
Hauptverfasser:	Chang, Haoya, Cheng, Siyu, Xing, Guoqiang, Huang, Chenyang, Zhang, Chunhui, Qian, Weiping, Li, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneuploidy Animals Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects early apoptosis Female Fertility Male Meiosis Meiosis - drug effects meiosis progression Mice Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology mouse oocyte Neurotoxicity Oocytes - drug effects Oxidative stress Oxidative Stress - drug effects spindle Spindle Apparatus - drug effects Vincristine Vincristine - adverse effects Vincristine - pharmacology
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