Influence of feeding and other factors on adrenocorticotropin concentration and thyrotropin‐releasing hormone stimulation test in horses and ponies
Background The basal (bACTH) and post‐thyrotropin‐releasing hormone stimulation concentration of adrenocorticotropin (pACTH) are recommended for diagnosis of pituitary pars intermedia dysfunction (PPID). Many factors influence bACTH (e.g., disease, age, month) and some affect the results only in aut...
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| Veröffentlicht in: | Equine veterinary journal 2024-03, Vol.56 (2), p.342-351 |
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| creator | Drozdzewska, Karolina Winter, Judith Barton, Ann Kristin Merle, Roswitha Gehlen, Heidrun |
| description | Background
The basal (bACTH) and post‐thyrotropin‐releasing hormone stimulation concentration of adrenocorticotropin (pACTH) are recommended for diagnosis of pituitary pars intermedia dysfunction (PPID). Many factors influence bACTH (e.g., disease, age, month) and some affect the results only in autumn (e.g., breed, colour, sex). There are discrepancies about the impact of feeding on b/pACTH.
Objectives
To determine whether feeding, month, age, breed, colour, sex and body condition score affect b/pACTH.
Study design
Prospective crossover.
Methods
Sixty‐one animals were divided into groups: healthy, PPID, treated‐PPID. The b/pACTH was measured three times (1 mg protirelin; blood collection after 10 min; mid‐November to mid‐July) after different feedings: fasting, hay, hay + grain. Friedman's test was applied to evaluate the influence of feeding on b/pACTH and linear mixed model to evaluate impact of further factors.
Results
The b/pACTH was not significantly affected by feeding (p = 0.7/0.5). The bACTH was lowest in healthy (29.3 pg/mL, CI 9–49.5 pg/mL) and highest in PPID‐group (58.9 pg/mL, CI 39.7–78.1 pg/mL). The pACTH was significantly lower in healthy (396.7 pg/mL, CI 283.2–510.1 pg/mL) compared to PPID (588.4 pg/mL, CI 480.7–696.2 pg/mL) and treated‐PPID group (683.1 pg/mL, CI 585.9–780.4 pg/mL), highest in July (881.2 pg/mL, CI 626.3–1136.3 pg/mL) and higher in grey (723.5 pg/mL, CI 577.5–869.4 pg/mL) than other colours (338.7 pg/mL, CI 324.8–452.5 pg/mL). The size of effect for those variables was >0.5.
Main limitations
Small number of animals, subsequent bACTH measurements were significantly lower in each horse.
Conclusions
There was no evidence that feeding influences the b/pACTH. There was evidence that pergolide affects the bACTH but it had little effect on pACTH. Further investigation of the impact of month and coat colour on b/pACTH is warranted to better interpret the results. |
| doi_str_mv | 10.1111/evj.14030 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2894721092</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2923208905</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3480-bfbafc717738e883ca4a60a2aad83575538a0f81b2c5f840a9d463b4c9f637c13</originalsourceid><addsrcrecordid>eNp1kc1u1DAURi0EotPCghdAltjQRVr_JXGWVVWgVSU2wNZynGvGo8Se2k6r2fEIbHjBPgmeZmCBhDfX0nfu0ZU-hN5QckbLO4f7zRkVhJNnaMWIYBXnpHmOVuVbV7QR4ggdp7QhhHMm2Et0xCWhRDbNCv269nacwRvAwWILMDj_HWs_4JDXELHVJoeYcPBYDxF8MCFmZ0KOYes8NqFs-hx1dnuirOX1Lh7Sxx8_I4yg0165DnEKHnDKbprHhc-QMi6WkiVIT-vb4B2kV-iF1WOC14d5gr5-uPpy-am6_fzx-vLitjJcSFL1ttfWtLRtuQQpudFCN0QzrQfJ67auudTEStozU1spiO4G0fBemM42vDWUn6D3i3cbw91crlGTSwbGUXsIc1JMdqJllHSsoO_-QTdhjr5cp1iJGZEdqQt1ulAmhpQiWLWNbtJxpyhR-65U6Uo9dVXYtwfj3E8w_CX_lFOA8wV4cCPs_m9SV99uFuVvFpaiLQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2923208905</pqid></control><display><type>article</type><title>Influence of feeding and other factors on adrenocorticotropin concentration and thyrotropin‐releasing hormone stimulation test in horses and ponies</title><source>Wiley-Blackwell Journals</source><creator>Drozdzewska, Karolina ; Winter, Judith ; Barton, Ann Kristin ; Merle, Roswitha ; Gehlen, Heidrun</creator><creatorcontrib>Drozdzewska, Karolina ; Winter, Judith ; Barton, Ann Kristin ; Merle, Roswitha ; Gehlen, Heidrun</creatorcontrib><description>Background
The basal (bACTH) and post‐thyrotropin‐releasing hormone stimulation concentration of adrenocorticotropin (pACTH) are recommended for diagnosis of pituitary pars intermedia dysfunction (PPID). Many factors influence bACTH (e.g., disease, age, month) and some affect the results only in autumn (e.g., breed, colour, sex). There are discrepancies about the impact of feeding on b/pACTH.
Objectives
To determine whether feeding, month, age, breed, colour, sex and body condition score affect b/pACTH.
Study design
Prospective crossover.
Methods
Sixty‐one animals were divided into groups: healthy, PPID, treated‐PPID. The b/pACTH was measured three times (1 mg protirelin; blood collection after 10 min; mid‐November to mid‐July) after different feedings: fasting, hay, hay + grain. Friedman's test was applied to evaluate the influence of feeding on b/pACTH and linear mixed model to evaluate impact of further factors.
Results
The b/pACTH was not significantly affected by feeding (p = 0.7/0.5). The bACTH was lowest in healthy (29.3 pg/mL, CI 9–49.5 pg/mL) and highest in PPID‐group (58.9 pg/mL, CI 39.7–78.1 pg/mL). The pACTH was significantly lower in healthy (396.7 pg/mL, CI 283.2–510.1 pg/mL) compared to PPID (588.4 pg/mL, CI 480.7–696.2 pg/mL) and treated‐PPID group (683.1 pg/mL, CI 585.9–780.4 pg/mL), highest in July (881.2 pg/mL, CI 626.3–1136.3 pg/mL) and higher in grey (723.5 pg/mL, CI 577.5–869.4 pg/mL) than other colours (338.7 pg/mL, CI 324.8–452.5 pg/mL). The size of effect for those variables was >0.5.
Main limitations
Small number of animals, subsequent bACTH measurements were significantly lower in each horse.
Conclusions
There was no evidence that feeding influences the b/pACTH. There was evidence that pergolide affects the bACTH but it had little effect on pACTH. Further investigation of the impact of month and coat colour on b/pACTH is warranted to better interpret the results.</description><identifier>ISSN: 0425-1644</identifier><identifier>EISSN: 2042-3306</identifier><identifier>DOI: 10.1111/evj.14030</identifier><identifier>PMID: 38010866</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>ACTH ; adrenocorticotropin ; endocrine ; horse ; Influence ; PPID ; TRH</subject><ispartof>Equine veterinary journal, 2024-03, Vol.56 (2), p.342-351</ispartof><rights>2023 The Authors. published by John Wiley & Sons Ltd on behalf of EVJ Ltd.</rights><rights>2023 The Authors. Equine Veterinary Journal published by John Wiley & Sons Ltd on behalf of EVJ Ltd.</rights><rights>2023. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3480-bfbafc717738e883ca4a60a2aad83575538a0f81b2c5f840a9d463b4c9f637c13</cites><orcidid>0000-0001-6972-9738 ; 0000-0002-3333-9647</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fevj.14030$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fevj.14030$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38010866$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Drozdzewska, Karolina</creatorcontrib><creatorcontrib>Winter, Judith</creatorcontrib><creatorcontrib>Barton, Ann Kristin</creatorcontrib><creatorcontrib>Merle, Roswitha</creatorcontrib><creatorcontrib>Gehlen, Heidrun</creatorcontrib><title>Influence of feeding and other factors on adrenocorticotropin concentration and thyrotropin‐releasing hormone stimulation test in horses and ponies</title><title>Equine veterinary journal</title><addtitle>Equine Vet J</addtitle><description>Background
The basal (bACTH) and post‐thyrotropin‐releasing hormone stimulation concentration of adrenocorticotropin (pACTH) are recommended for diagnosis of pituitary pars intermedia dysfunction (PPID). Many factors influence bACTH (e.g., disease, age, month) and some affect the results only in autumn (e.g., breed, colour, sex). There are discrepancies about the impact of feeding on b/pACTH.
Objectives
To determine whether feeding, month, age, breed, colour, sex and body condition score affect b/pACTH.
Study design
Prospective crossover.
Methods
Sixty‐one animals were divided into groups: healthy, PPID, treated‐PPID. The b/pACTH was measured three times (1 mg protirelin; blood collection after 10 min; mid‐November to mid‐July) after different feedings: fasting, hay, hay + grain. Friedman's test was applied to evaluate the influence of feeding on b/pACTH and linear mixed model to evaluate impact of further factors.
Results
The b/pACTH was not significantly affected by feeding (p = 0.7/0.5). The bACTH was lowest in healthy (29.3 pg/mL, CI 9–49.5 pg/mL) and highest in PPID‐group (58.9 pg/mL, CI 39.7–78.1 pg/mL). The pACTH was significantly lower in healthy (396.7 pg/mL, CI 283.2–510.1 pg/mL) compared to PPID (588.4 pg/mL, CI 480.7–696.2 pg/mL) and treated‐PPID group (683.1 pg/mL, CI 585.9–780.4 pg/mL), highest in July (881.2 pg/mL, CI 626.3–1136.3 pg/mL) and higher in grey (723.5 pg/mL, CI 577.5–869.4 pg/mL) than other colours (338.7 pg/mL, CI 324.8–452.5 pg/mL). The size of effect for those variables was >0.5.
Main limitations
Small number of animals, subsequent bACTH measurements were significantly lower in each horse.
Conclusions
There was no evidence that feeding influences the b/pACTH. There was evidence that pergolide affects the bACTH but it had little effect on pACTH. Further investigation of the impact of month and coat colour on b/pACTH is warranted to better interpret the results.</description><subject>ACTH</subject><subject>adrenocorticotropin</subject><subject>endocrine</subject><subject>horse</subject><subject>Influence</subject><subject>PPID</subject><subject>TRH</subject><issn>0425-1644</issn><issn>2042-3306</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp1kc1u1DAURi0EotPCghdAltjQRVr_JXGWVVWgVSU2wNZynGvGo8Se2k6r2fEIbHjBPgmeZmCBhDfX0nfu0ZU-hN5QckbLO4f7zRkVhJNnaMWIYBXnpHmOVuVbV7QR4ggdp7QhhHMm2Et0xCWhRDbNCv269nacwRvAwWILMDj_HWs_4JDXELHVJoeYcPBYDxF8MCFmZ0KOYes8NqFs-hx1dnuirOX1Lh7Sxx8_I4yg0165DnEKHnDKbprHhc-QMi6WkiVIT-vb4B2kV-iF1WOC14d5gr5-uPpy-am6_fzx-vLitjJcSFL1ttfWtLRtuQQpudFCN0QzrQfJ67auudTEStozU1spiO4G0fBemM42vDWUn6D3i3cbw91crlGTSwbGUXsIc1JMdqJllHSsoO_-QTdhjr5cp1iJGZEdqQt1ulAmhpQiWLWNbtJxpyhR-65U6Uo9dVXYtwfj3E8w_CX_lFOA8wV4cCPs_m9SV99uFuVvFpaiLQ</recordid><startdate>202403</startdate><enddate>202403</enddate><creator>Drozdzewska, Karolina</creator><creator>Winter, Judith</creator><creator>Barton, Ann Kristin</creator><creator>Merle, Roswitha</creator><creator>Gehlen, Heidrun</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6972-9738</orcidid><orcidid>https://orcid.org/0000-0002-3333-9647</orcidid></search><sort><creationdate>202403</creationdate><title>Influence of feeding and other factors on adrenocorticotropin concentration and thyrotropin‐releasing hormone stimulation test in horses and ponies</title><author>Drozdzewska, Karolina ; Winter, Judith ; Barton, Ann Kristin ; Merle, Roswitha ; Gehlen, Heidrun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3480-bfbafc717738e883ca4a60a2aad83575538a0f81b2c5f840a9d463b4c9f637c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>ACTH</topic><topic>adrenocorticotropin</topic><topic>endocrine</topic><topic>horse</topic><topic>Influence</topic><topic>PPID</topic><topic>TRH</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Drozdzewska, Karolina</creatorcontrib><creatorcontrib>Winter, Judith</creatorcontrib><creatorcontrib>Barton, Ann Kristin</creatorcontrib><creatorcontrib>Merle, Roswitha</creatorcontrib><creatorcontrib>Gehlen, Heidrun</creatorcontrib><collection>Wiley_OA刊</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Equine veterinary journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drozdzewska, Karolina</au><au>Winter, Judith</au><au>Barton, Ann Kristin</au><au>Merle, Roswitha</au><au>Gehlen, Heidrun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of feeding and other factors on adrenocorticotropin concentration and thyrotropin‐releasing hormone stimulation test in horses and ponies</atitle><jtitle>Equine veterinary journal</jtitle><addtitle>Equine Vet J</addtitle><date>2024-03</date><risdate>2024</risdate><volume>56</volume><issue>2</issue><spage>342</spage><epage>351</epage><pages>342-351</pages><issn>0425-1644</issn><eissn>2042-3306</eissn><abstract>Background
The basal (bACTH) and post‐thyrotropin‐releasing hormone stimulation concentration of adrenocorticotropin (pACTH) are recommended for diagnosis of pituitary pars intermedia dysfunction (PPID). Many factors influence bACTH (e.g., disease, age, month) and some affect the results only in autumn (e.g., breed, colour, sex). There are discrepancies about the impact of feeding on b/pACTH.
Objectives
To determine whether feeding, month, age, breed, colour, sex and body condition score affect b/pACTH.
Study design
Prospective crossover.
Methods
Sixty‐one animals were divided into groups: healthy, PPID, treated‐PPID. The b/pACTH was measured three times (1 mg protirelin; blood collection after 10 min; mid‐November to mid‐July) after different feedings: fasting, hay, hay + grain. Friedman's test was applied to evaluate the influence of feeding on b/pACTH and linear mixed model to evaluate impact of further factors.
Results
The b/pACTH was not significantly affected by feeding (p = 0.7/0.5). The bACTH was lowest in healthy (29.3 pg/mL, CI 9–49.5 pg/mL) and highest in PPID‐group (58.9 pg/mL, CI 39.7–78.1 pg/mL). The pACTH was significantly lower in healthy (396.7 pg/mL, CI 283.2–510.1 pg/mL) compared to PPID (588.4 pg/mL, CI 480.7–696.2 pg/mL) and treated‐PPID group (683.1 pg/mL, CI 585.9–780.4 pg/mL), highest in July (881.2 pg/mL, CI 626.3–1136.3 pg/mL) and higher in grey (723.5 pg/mL, CI 577.5–869.4 pg/mL) than other colours (338.7 pg/mL, CI 324.8–452.5 pg/mL). The size of effect for those variables was >0.5.
Main limitations
Small number of animals, subsequent bACTH measurements were significantly lower in each horse.
Conclusions
There was no evidence that feeding influences the b/pACTH. There was evidence that pergolide affects the bACTH but it had little effect on pACTH. Further investigation of the impact of month and coat colour on b/pACTH is warranted to better interpret the results.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38010866</pmid><doi>10.1111/evj.14030</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6972-9738</orcidid><orcidid>https://orcid.org/0000-0002-3333-9647</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Equine veterinary journal, 2024-03, Vol.56 (2), p.342-351 |
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| language | eng |
| recordid | cdi_proquest_miscellaneous_2894721092 |
| source | Wiley-Blackwell Journals |
| subjects | ACTH adrenocorticotropin endocrine horse Influence PPID TRH |
| title | Influence of feeding and other factors on adrenocorticotropin concentration and thyrotropin‐releasing hormone stimulation test in horses and ponies |
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