Na+/H+ exchanger NHE1 is active at cell–cell contacts and facilitates cell dissemination during collective migration of melanoma cells

Tumour cell detachment from the primary tumour is an early and crucial step of the metastatic cascade. At the single cell level, it was already shown that migrating melanoma cells establish both intra‐ and extracellular pH gradients and that the Na+/H+ exchanger NHE1 accumulates at the leading edges...

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