Phase I LITESPARK-001 study of belzutifan for advanced solid tumors: Extended 41-month follow-up in the clear cell renal cell carcinoma cohort

Accumulation of the HIF-2α transcription factor is an oncogenic event implicated in the tumorigenesis of clear cell renal cell carcinoma (ccRCC). In the phase I LITESPARK-001 study, the first-in-class HIF-2α inhibitor belzutifan demonstrated antitumor activity and an acceptable safety profile for pr...

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Veröffentlicht in:	European journal of cancer (1990) 2024-01, Vol.196, p.113434-113434, Article 113434
Hauptverfasser:	Jonasch, Eric, Bauer, Todd M, Papadopoulos, Kyriakos P, Plimack, Elizabeth R, Merchan, Jaime R, McDermott, David F, Dror Michaelson, M, Appleman, Leonard J, Roy, Ananya, Perini, Rodolfo F, Liu, Yanfang, Choueiri, Toni K
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Helix-Loop-Helix Transcription Factors - therapeutic use Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - pathology Follow-Up Studies Humans Kidney Neoplasms - drug therapy Kidney Neoplasms - pathology
Online-Zugang:	Volltext
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