Diversity of atopic dermatitis and selection of immune targets
Atopic dermatitis (AD) is a heterogeneous immune-mediated skin disorder affecting people of all ages and ethnicities. Despite the development of targeted therapeutics such as biologics and Janus kinase inhibitors, attaining complete clinical efficacy remains difficult. This therapeutic challenge may...
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| Veröffentlicht in: | Annals of allergy, asthma, & immunology asthma, & immunology, 2024-02, Vol.132 (2), p.177-186 |
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| container_title | Annals of allergy, asthma, & immunology |
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| creator | Rothenberg-Lausell, Camille Bar, Jonathan Del Duca, Ester Guttman-Yassky, Emma |
| description | Atopic dermatitis (AD) is a heterogeneous immune-mediated skin disorder affecting people of all ages and ethnicities. Despite the development of targeted therapeutics such as biologics and Janus kinase inhibitors, attaining complete clinical efficacy remains difficult. This therapeutic challenge may be attributed to the complex pathogenesis of AD. Although the T
2 axis has been extensively studied, recent advancements have started to reveal the involvement of additional immune pathways including T
1, T
17, and T
22. Understanding the interplay of these immune axes may contribute to a more personalized therapeutic approach based on patients' molecular profile, with the prospect of improving clinical outcome. This review will discuss studies exploring the molecular profile of AD in both skin and blood across age, ethnicity/race, disease chronicity, IgE levels, filaggrin mutation status, and AD association with other atopic conditions. Moreover, it will explore the potential of personalized treatment strategies based on a patient's distinct immune signature. |
| doi_str_mv | 10.1016/j.anai.2023.11.020 |
| format | Article |
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2 axis has been extensively studied, recent advancements have started to reveal the involvement of additional immune pathways including T
1, T
17, and T
22. Understanding the interplay of these immune axes may contribute to a more personalized therapeutic approach based on patients' molecular profile, with the prospect of improving clinical outcome. This review will discuss studies exploring the molecular profile of AD in both skin and blood across age, ethnicity/race, disease chronicity, IgE levels, filaggrin mutation status, and AD association with other atopic conditions. Moreover, it will explore the potential of personalized treatment strategies based on a patient's distinct immune signature.</description><identifier>ISSN: 1081-1206</identifier><identifier>ISSN: 1534-4436</identifier><identifier>EISSN: 1534-4436</identifier><identifier>DOI: 10.1016/j.anai.2023.11.020</identifier><identifier>PMID: 38008215</identifier><language>eng</language><publisher>United States</publisher><subject>Cytokines - metabolism ; Dermatitis, Atopic - drug therapy ; Dermatitis, Atopic - genetics ; Humans ; Immunoglobulin E ; Skin - pathology ; Th2 Cells</subject><ispartof>Annals of allergy, asthma, & immunology, 2024-02, Vol.132 (2), p.177-186</ispartof><rights>Copyright © 2023 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-5d97087075a587dd7606b908c164ca378a3afdbd1df6d09e86b0b43a1476cac3</citedby><cites>FETCH-LOGICAL-c347t-5d97087075a587dd7606b908c164ca378a3afdbd1df6d09e86b0b43a1476cac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38008215$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rothenberg-Lausell, Camille</creatorcontrib><creatorcontrib>Bar, Jonathan</creatorcontrib><creatorcontrib>Del Duca, Ester</creatorcontrib><creatorcontrib>Guttman-Yassky, Emma</creatorcontrib><title>Diversity of atopic dermatitis and selection of immune targets</title><title>Annals of allergy, asthma, & immunology</title><addtitle>Ann Allergy Asthma Immunol</addtitle><description>Atopic dermatitis (AD) is a heterogeneous immune-mediated skin disorder affecting people of all ages and ethnicities. Despite the development of targeted therapeutics such as biologics and Janus kinase inhibitors, attaining complete clinical efficacy remains difficult. This therapeutic challenge may be attributed to the complex pathogenesis of AD. Although the T
2 axis has been extensively studied, recent advancements have started to reveal the involvement of additional immune pathways including T
1, T
17, and T
22. Understanding the interplay of these immune axes may contribute to a more personalized therapeutic approach based on patients' molecular profile, with the prospect of improving clinical outcome. This review will discuss studies exploring the molecular profile of AD in both skin and blood across age, ethnicity/race, disease chronicity, IgE levels, filaggrin mutation status, and AD association with other atopic conditions. Moreover, it will explore the potential of personalized treatment strategies based on a patient's distinct immune signature.</description><subject>Cytokines - metabolism</subject><subject>Dermatitis, Atopic - drug therapy</subject><subject>Dermatitis, Atopic - genetics</subject><subject>Humans</subject><subject>Immunoglobulin E</subject><subject>Skin - pathology</subject><subject>Th2 Cells</subject><issn>1081-1206</issn><issn>1534-4436</issn><issn>1534-4436</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtOwzAQRS0EoqXwAyxQlmwSZmLHdjZIqDylSmy6txzbQa7yKLGD1L8nUQuruYtzrzSHkFuEDAH5wy7TnfZZDjnNEDPI4YwssaAsZYzy8ymDxBRz4AtyFcIOAFByekkWVALIHIsleXz2P24IPh6Svk507PfeJNYNrY4--pDozibBNc5E33cz4tt27FwS9fDlYrgmF7Vugrs53RXZvr5s1-_p5vPtY_20SQ1lIqaFLQVIAaLQhRTWCg68KkEa5MxoKqSmuraVRVtzC6WTvIKKUY1McKMNXZH74-x-6L9HF6JqfTCuaXTn-jGoXJbTxyAZTmh-RM3QhzC4Wu0H3-rhoBDUrE3t1KxNzdoUopq0TaW70_5Ytc7-V_480V_ZV2lv</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Rothenberg-Lausell, Camille</creator><creator>Bar, Jonathan</creator><creator>Del Duca, Ester</creator><creator>Guttman-Yassky, Emma</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202402</creationdate><title>Diversity of atopic dermatitis and selection of immune targets</title><author>Rothenberg-Lausell, Camille ; Bar, Jonathan ; Del Duca, Ester ; Guttman-Yassky, Emma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-5d97087075a587dd7606b908c164ca378a3afdbd1df6d09e86b0b43a1476cac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cytokines - metabolism</topic><topic>Dermatitis, Atopic - drug therapy</topic><topic>Dermatitis, Atopic - genetics</topic><topic>Humans</topic><topic>Immunoglobulin E</topic><topic>Skin - pathology</topic><topic>Th2 Cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rothenberg-Lausell, Camille</creatorcontrib><creatorcontrib>Bar, Jonathan</creatorcontrib><creatorcontrib>Del Duca, Ester</creatorcontrib><creatorcontrib>Guttman-Yassky, Emma</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of allergy, asthma, & immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rothenberg-Lausell, Camille</au><au>Bar, Jonathan</au><au>Del Duca, Ester</au><au>Guttman-Yassky, Emma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diversity of atopic dermatitis and selection of immune targets</atitle><jtitle>Annals of allergy, asthma, & immunology</jtitle><addtitle>Ann Allergy Asthma Immunol</addtitle><date>2024-02</date><risdate>2024</risdate><volume>132</volume><issue>2</issue><spage>177</spage><epage>186</epage><pages>177-186</pages><issn>1081-1206</issn><issn>1534-4436</issn><eissn>1534-4436</eissn><abstract>Atopic dermatitis (AD) is a heterogeneous immune-mediated skin disorder affecting people of all ages and ethnicities. Despite the development of targeted therapeutics such as biologics and Janus kinase inhibitors, attaining complete clinical efficacy remains difficult. This therapeutic challenge may be attributed to the complex pathogenesis of AD. Although the T
2 axis has been extensively studied, recent advancements have started to reveal the involvement of additional immune pathways including T
1, T
17, and T
22. Understanding the interplay of these immune axes may contribute to a more personalized therapeutic approach based on patients' molecular profile, with the prospect of improving clinical outcome. This review will discuss studies exploring the molecular profile of AD in both skin and blood across age, ethnicity/race, disease chronicity, IgE levels, filaggrin mutation status, and AD association with other atopic conditions. Moreover, it will explore the potential of personalized treatment strategies based on a patient's distinct immune signature.</abstract><cop>United States</cop><pmid>38008215</pmid><doi>10.1016/j.anai.2023.11.020</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1081-1206 |
| ispartof | Annals of allergy, asthma, & immunology, 2024-02, Vol.132 (2), p.177-186 |
| issn | 1081-1206 1534-4436 1534-4436 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Cytokines - metabolism Dermatitis, Atopic - drug therapy Dermatitis, Atopic - genetics Humans Immunoglobulin E Skin - pathology Th2 Cells |
| title | Diversity of atopic dermatitis and selection of immune targets |
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