A pH-sensitive silica nanoparticles for colon-specific delivery and controlled release of catechin: Optimization of loading efficiency and in vitro release kinetics

Catechin is a naturally occurring flavonoid of the flavan-3-ol subclass with numerous biological functions; however, these benefits are diminished due to several factors, including low water solubility and degradation in the stomach's harsh environment. So, this study aimed to develop an intell...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2024-01, Vol.192, p.106652-106652, Article 106652
Hauptverfasser:	Kassem, Abdulsalam M., Almukainzi, May, Faris, Tarek M., Ibrahim, Ahmed H., Anwar, Walid, Elbahwy, Ibrahim A., El-Gamal, Farid R., Zidan, Mohamed F., Akl, Mohamed A., Abd-ElGawad, Ahmed M., Elshamy, Abdelsamed I., Elmowafy, Mohammed
Format:	Artikel
Sprache:	eng
Schlagworte:	Catechin Colon - metabolism Colon targeting Delayed-Action Preparations - metabolism Drug Carriers - chemistry Drug Delivery Systems Eudragit®-S100 Hydrogen-Ion Concentration Mesoporous silica nanoparticles Nanoparticles - chemistry pH-responsive drug delivery system Porosity Silicon Dioxide - chemistry Spectroscopy, Fourier Transform Infrared
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