Effects of Remimazolam on Intracellular Calcium Dynamics in Myotubes Derived from Patients with Malignant Hyperthermia and Functional Analysis of Type 1 Ryanodine Receptor Gene Variants

Remimazolam is a novel general anesthetic and its safety in patients with malignant hyperthermia (MH) is unknown. We used myotubes derived from the skeletal muscle of patients with MH to examine the response to ryanodine receptor 1 (RYR1) agonist and remimazolam in MH-susceptible patients. Patients...

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Veröffentlicht in:	Genes 2023-10, Vol.14 (11), p.2009
Hauptverfasser:	Miyoshi, Hirotsugu, Otsuki, Sachiko, Mukaida, Keiko, Kido, Kenshiro, Sumii, Ayako, Ikeda, Tsuyoshi, Noda, Yuko, Yasuda, Toshimichi, Narasaki, Soshi, Kato, Takahiro, Kamiya, Satoshi, Horikawa, Yousuke T, Tsutsumi, Yasuo M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Anesthetics Benzodiazepines Biopsy Caffeine Caffeine - pharmacology Calcium (intracellular) Calcium - metabolism Calcium channels (voltage-gated) Calcium signalling Case reports Channel gating Cresol Fever Gene mutations General anesthesia Genes Genetic aspects Genetic research Genetic screening Genetic testing Humans Hybridization Hyperthermia Intracellular Malignant hyperthermia Malignant Hyperthermia - drug therapy Malignant Hyperthermia - genetics Muscle Fibers, Skeletal - metabolism Muscles Musculoskeletal system Mutation Myotubes Patients Ryanodine Receptor Calcium Release Channel - genetics Ryanodine receptors Skeletal muscle Stimulants
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