Aqueous Dispersion of Manganese–Zinc Ferrite Nanoparticles Protected by PEG as a T2 MRI Temperature Contrast Agent

Mixed manganese–zinc ferrite nanoparticles coated with PEG were studied for their potential usefulness in MRI thermometry as temperature-sensitive contrast agents. Particles in the form of an 8.5 nm core coated with a 3.5 nm layer of PEG were fabricated using a newly developed, one-step method. The...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International journal of molecular sciences 2023-11, Vol.24 (22), p.16458
Hauptverfasser: Lachowicz, Dorota, Kmita, Angelika, Gajewska, Marta, Trynkiewicz, Elżbieta, Przybylski, Marek, Russek, Stephen E., Stupic, Karl F., Woodrum, David A., Gorny, Krzysztof R., Celinski, Zbigniew J., Hankiewicz, Janusz H.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 22
container_start_page 16458
container_title International journal of molecular sciences
container_volume 24
creator Lachowicz, Dorota
Kmita, Angelika
Gajewska, Marta
Trynkiewicz, Elżbieta
Przybylski, Marek
Russek, Stephen E.
Stupic, Karl F.
Woodrum, David A.
Gorny, Krzysztof R.
Celinski, Zbigniew J.
Hankiewicz, Janusz H.
description Mixed manganese–zinc ferrite nanoparticles coated with PEG were studied for their potential usefulness in MRI thermometry as temperature-sensitive contrast agents. Particles in the form of an 8.5 nm core coated with a 3.5 nm layer of PEG were fabricated using a newly developed, one-step method. The composition of Mn0.48Zn0.46Fe2.06O4 was found to have a strong thermal dependence of magnetization in the temperature range between 5 and 50 °C. Nanoparticles suspended in an agar gel mimicking animal tissue and showing non-significant impact on cell viability in the biological test were studied with NMR and MRI over the same temperature range. For the concentration of 0.017 mg/mL of Fe, the spin–spin relaxation time T2 increased from 3.1 to 8.3 ms, while longitudinal relaxation time T1 shows a moderate decrease from 149.0 to 125.1 ms. A temperature map of the phantom exposed to the radial temperature gradient obtained by heating it with an 808 nm laser was calculated from T2 weighted spin-echo differential MR images. Analysis of temperature maps yields thermal/spatial resolution of 3.2 °C at the distance of 2.9 mm. The experimental relaxation rate R2 data of water protons were compared with those obtained from calculations using a theoretical model incorporating the motion averaging regime.
doi_str_mv 10.3390/ijms242216458
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2893842869</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2893070969</sourcerecordid><originalsourceid>FETCH-LOGICAL-c337t-92a8b7025dd71a0f0aa9691cbe55031f7b2dd18a6840d21a7e119105a9044f643</originalsourceid><addsrcrecordid>eNpdkb1OwzAUhSMEEqUwsltiYQn4J38eq9KWSgUqVBaW6Ca5qVwldrGdoRvvwBvyJISWAZjuGT4d3U8nCC4ZvRFC0lu1aR2POGdJFGdHwYD1OaQ0SY9_5dPgzLkNpVzwWA4CP3rr0HSO3Cm3ReuU0cTU5AH0GjQ6_Hz_eFW6JFO0Vnkkj6DNFqxXZYOOLK3xWHqsSLEjy8mMgCNAVpw8PM_JCtu-EXxnkYyN9hacJ6M1an8enNTQOLz4ucPgZTpZje_DxdNsPh4twlKI1IeSQ1aklMdVlTKgNQWQiWRlgXFMBavTglcVyyDJIlpxBikyJhmNQdIoqpNIDIPrQ-_Wml7T-bxVrsSm6dV655xnUmQRzxLZo1f_0I3prO6_21M0pXJPhQeqtMY5i3W-taoFu8sZzb83yP9sIL4AbIx5-g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2893070969</pqid></control><display><type>article</type><title>Aqueous Dispersion of Manganese–Zinc Ferrite Nanoparticles Protected by PEG as a T2 MRI Temperature Contrast Agent</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><creator>Lachowicz, Dorota ; Kmita, Angelika ; Gajewska, Marta ; Trynkiewicz, Elżbieta ; Przybylski, Marek ; Russek, Stephen E. ; Stupic, Karl F. ; Woodrum, David A. ; Gorny, Krzysztof R. ; Celinski, Zbigniew J. ; Hankiewicz, Janusz H.</creator><creatorcontrib>Lachowicz, Dorota ; Kmita, Angelika ; Gajewska, Marta ; Trynkiewicz, Elżbieta ; Przybylski, Marek ; Russek, Stephen E. ; Stupic, Karl F. ; Woodrum, David A. ; Gorny, Krzysztof R. ; Celinski, Zbigniew J. ; Hankiewicz, Janusz H.</creatorcontrib><description>Mixed manganese–zinc ferrite nanoparticles coated with PEG were studied for their potential usefulness in MRI thermometry as temperature-sensitive contrast agents. Particles in the form of an 8.5 nm core coated with a 3.5 nm layer of PEG were fabricated using a newly developed, one-step method. The composition of Mn0.48Zn0.46Fe2.06O4 was found to have a strong thermal dependence of magnetization in the temperature range between 5 and 50 °C. Nanoparticles suspended in an agar gel mimicking animal tissue and showing non-significant impact on cell viability in the biological test were studied with NMR and MRI over the same temperature range. For the concentration of 0.017 mg/mL of Fe, the spin–spin relaxation time T2 increased from 3.1 to 8.3 ms, while longitudinal relaxation time T1 shows a moderate decrease from 149.0 to 125.1 ms. A temperature map of the phantom exposed to the radial temperature gradient obtained by heating it with an 808 nm laser was calculated from T2 weighted spin-echo differential MR images. Analysis of temperature maps yields thermal/spatial resolution of 3.2 °C at the distance of 2.9 mm. The experimental relaxation rate R2 data of water protons were compared with those obtained from calculations using a theoretical model incorporating the motion averaging regime.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms242216458</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Contrast agents ; Decomposition ; Electrons ; Magnetic fields ; Magnetic resonance imaging ; Microscopy ; Nanoparticles ; Polyethylene glycol ; Polymers ; Spectrum analysis ; Zinc ferrites</subject><ispartof>International journal of molecular sciences, 2023-11, Vol.24 (22), p.16458</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-92a8b7025dd71a0f0aa9691cbe55031f7b2dd18a6840d21a7e119105a9044f643</citedby><cites>FETCH-LOGICAL-c337t-92a8b7025dd71a0f0aa9691cbe55031f7b2dd18a6840d21a7e119105a9044f643</cites><orcidid>0000-0002-9989-3907 ; 0000-0001-8634-2084 ; 0000-0002-6479-7886 ; 0000-0003-3303-3768 ; 0000-0001-9394-5297 ; 0000-0002-8788-2442</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Lachowicz, Dorota</creatorcontrib><creatorcontrib>Kmita, Angelika</creatorcontrib><creatorcontrib>Gajewska, Marta</creatorcontrib><creatorcontrib>Trynkiewicz, Elżbieta</creatorcontrib><creatorcontrib>Przybylski, Marek</creatorcontrib><creatorcontrib>Russek, Stephen E.</creatorcontrib><creatorcontrib>Stupic, Karl F.</creatorcontrib><creatorcontrib>Woodrum, David A.</creatorcontrib><creatorcontrib>Gorny, Krzysztof R.</creatorcontrib><creatorcontrib>Celinski, Zbigniew J.</creatorcontrib><creatorcontrib>Hankiewicz, Janusz H.</creatorcontrib><title>Aqueous Dispersion of Manganese–Zinc Ferrite Nanoparticles Protected by PEG as a T2 MRI Temperature Contrast Agent</title><title>International journal of molecular sciences</title><description>Mixed manganese–zinc ferrite nanoparticles coated with PEG were studied for their potential usefulness in MRI thermometry as temperature-sensitive contrast agents. Particles in the form of an 8.5 nm core coated with a 3.5 nm layer of PEG were fabricated using a newly developed, one-step method. The composition of Mn0.48Zn0.46Fe2.06O4 was found to have a strong thermal dependence of magnetization in the temperature range between 5 and 50 °C. Nanoparticles suspended in an agar gel mimicking animal tissue and showing non-significant impact on cell viability in the biological test were studied with NMR and MRI over the same temperature range. For the concentration of 0.017 mg/mL of Fe, the spin–spin relaxation time T2 increased from 3.1 to 8.3 ms, while longitudinal relaxation time T1 shows a moderate decrease from 149.0 to 125.1 ms. A temperature map of the phantom exposed to the radial temperature gradient obtained by heating it with an 808 nm laser was calculated from T2 weighted spin-echo differential MR images. Analysis of temperature maps yields thermal/spatial resolution of 3.2 °C at the distance of 2.9 mm. The experimental relaxation rate R2 data of water protons were compared with those obtained from calculations using a theoretical model incorporating the motion averaging regime.</description><subject>Contrast agents</subject><subject>Decomposition</subject><subject>Electrons</subject><subject>Magnetic fields</subject><subject>Magnetic resonance imaging</subject><subject>Microscopy</subject><subject>Nanoparticles</subject><subject>Polyethylene glycol</subject><subject>Polymers</subject><subject>Spectrum analysis</subject><subject>Zinc ferrites</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkb1OwzAUhSMEEqUwsltiYQn4J38eq9KWSgUqVBaW6Ca5qVwldrGdoRvvwBvyJISWAZjuGT4d3U8nCC4ZvRFC0lu1aR2POGdJFGdHwYD1OaQ0SY9_5dPgzLkNpVzwWA4CP3rr0HSO3Cm3ReuU0cTU5AH0GjQ6_Hz_eFW6JFO0Vnkkj6DNFqxXZYOOLK3xWHqsSLEjy8mMgCNAVpw8PM_JCtu-EXxnkYyN9hacJ6M1an8enNTQOLz4ucPgZTpZje_DxdNsPh4twlKI1IeSQ1aklMdVlTKgNQWQiWRlgXFMBavTglcVyyDJIlpxBikyJhmNQdIoqpNIDIPrQ-_Wml7T-bxVrsSm6dV655xnUmQRzxLZo1f_0I3prO6_21M0pXJPhQeqtMY5i3W-taoFu8sZzb83yP9sIL4AbIx5-g</recordid><startdate>20231117</startdate><enddate>20231117</enddate><creator>Lachowicz, Dorota</creator><creator>Kmita, Angelika</creator><creator>Gajewska, Marta</creator><creator>Trynkiewicz, Elżbieta</creator><creator>Przybylski, Marek</creator><creator>Russek, Stephen E.</creator><creator>Stupic, Karl F.</creator><creator>Woodrum, David A.</creator><creator>Gorny, Krzysztof R.</creator><creator>Celinski, Zbigniew J.</creator><creator>Hankiewicz, Janusz H.</creator><general>MDPI AG</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9989-3907</orcidid><orcidid>https://orcid.org/0000-0001-8634-2084</orcidid><orcidid>https://orcid.org/0000-0002-6479-7886</orcidid><orcidid>https://orcid.org/0000-0003-3303-3768</orcidid><orcidid>https://orcid.org/0000-0001-9394-5297</orcidid><orcidid>https://orcid.org/0000-0002-8788-2442</orcidid></search><sort><creationdate>20231117</creationdate><title>Aqueous Dispersion of Manganese–Zinc Ferrite Nanoparticles Protected by PEG as a T2 MRI Temperature Contrast Agent</title><author>Lachowicz, Dorota ; Kmita, Angelika ; Gajewska, Marta ; Trynkiewicz, Elżbieta ; Przybylski, Marek ; Russek, Stephen E. ; Stupic, Karl F. ; Woodrum, David A. ; Gorny, Krzysztof R. ; Celinski, Zbigniew J. ; Hankiewicz, Janusz H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-92a8b7025dd71a0f0aa9691cbe55031f7b2dd18a6840d21a7e119105a9044f643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Contrast agents</topic><topic>Decomposition</topic><topic>Electrons</topic><topic>Magnetic fields</topic><topic>Magnetic resonance imaging</topic><topic>Microscopy</topic><topic>Nanoparticles</topic><topic>Polyethylene glycol</topic><topic>Polymers</topic><topic>Spectrum analysis</topic><topic>Zinc ferrites</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lachowicz, Dorota</creatorcontrib><creatorcontrib>Kmita, Angelika</creatorcontrib><creatorcontrib>Gajewska, Marta</creatorcontrib><creatorcontrib>Trynkiewicz, Elżbieta</creatorcontrib><creatorcontrib>Przybylski, Marek</creatorcontrib><creatorcontrib>Russek, Stephen E.</creatorcontrib><creatorcontrib>Stupic, Karl F.</creatorcontrib><creatorcontrib>Woodrum, David A.</creatorcontrib><creatorcontrib>Gorny, Krzysztof R.</creatorcontrib><creatorcontrib>Celinski, Zbigniew J.</creatorcontrib><creatorcontrib>Hankiewicz, Janusz H.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lachowicz, Dorota</au><au>Kmita, Angelika</au><au>Gajewska, Marta</au><au>Trynkiewicz, Elżbieta</au><au>Przybylski, Marek</au><au>Russek, Stephen E.</au><au>Stupic, Karl F.</au><au>Woodrum, David A.</au><au>Gorny, Krzysztof R.</au><au>Celinski, Zbigniew J.</au><au>Hankiewicz, Janusz H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aqueous Dispersion of Manganese–Zinc Ferrite Nanoparticles Protected by PEG as a T2 MRI Temperature Contrast Agent</atitle><jtitle>International journal of molecular sciences</jtitle><date>2023-11-17</date><risdate>2023</risdate><volume>24</volume><issue>22</issue><spage>16458</spage><pages>16458-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Mixed manganese–zinc ferrite nanoparticles coated with PEG were studied for their potential usefulness in MRI thermometry as temperature-sensitive contrast agents. Particles in the form of an 8.5 nm core coated with a 3.5 nm layer of PEG were fabricated using a newly developed, one-step method. The composition of Mn0.48Zn0.46Fe2.06O4 was found to have a strong thermal dependence of magnetization in the temperature range between 5 and 50 °C. Nanoparticles suspended in an agar gel mimicking animal tissue and showing non-significant impact on cell viability in the biological test were studied with NMR and MRI over the same temperature range. For the concentration of 0.017 mg/mL of Fe, the spin–spin relaxation time T2 increased from 3.1 to 8.3 ms, while longitudinal relaxation time T1 shows a moderate decrease from 149.0 to 125.1 ms. A temperature map of the phantom exposed to the radial temperature gradient obtained by heating it with an 808 nm laser was calculated from T2 weighted spin-echo differential MR images. Analysis of temperature maps yields thermal/spatial resolution of 3.2 °C at the distance of 2.9 mm. The experimental relaxation rate R2 data of water protons were compared with those obtained from calculations using a theoretical model incorporating the motion averaging regime.</abstract><cop>Basel</cop><pub>MDPI AG</pub><doi>10.3390/ijms242216458</doi><orcidid>https://orcid.org/0000-0002-9989-3907</orcidid><orcidid>https://orcid.org/0000-0001-8634-2084</orcidid><orcidid>https://orcid.org/0000-0002-6479-7886</orcidid><orcidid>https://orcid.org/0000-0003-3303-3768</orcidid><orcidid>https://orcid.org/0000-0001-9394-5297</orcidid><orcidid>https://orcid.org/0000-0002-8788-2442</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1422-0067
ispartof International journal of molecular sciences, 2023-11, Vol.24 (22), p.16458
issn 1422-0067
1661-6596
1422-0067
language eng
recordid cdi_proquest_miscellaneous_2893842869
source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central
subjects Contrast agents
Decomposition
Electrons
Magnetic fields
Magnetic resonance imaging
Microscopy
Nanoparticles
Polyethylene glycol
Polymers
Spectrum analysis
Zinc ferrites
title Aqueous Dispersion of Manganese–Zinc Ferrite Nanoparticles Protected by PEG as a T2 MRI Temperature Contrast Agent
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T00%3A56%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aqueous%20Dispersion%20of%20Manganese%E2%80%93Zinc%20Ferrite%20Nanoparticles%20Protected%20by%20PEG%20as%20a%20T2%20MRI%20Temperature%20Contrast%20Agent&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Lachowicz,%20Dorota&rft.date=2023-11-17&rft.volume=24&rft.issue=22&rft.spage=16458&rft.pages=16458-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms242216458&rft_dat=%3Cproquest_cross%3E2893070969%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2893070969&rft_id=info:pmid/&rfr_iscdi=true