Dispensing of antineoplastic medications and their impact on the dispensing of anti-dementia drugs for adults aged ≥60 years: A cohort study

Dispensing of antineoplastic medications and their impact on the dispensing of anti-dementia drugs for adults aged ≥60 years: A cohort study

History of cancer has been associated with decreased risk of dementia, but it is unclear if this is due to the use of antineoplastic medications. Participants were 442,795 adults aged ≥60 years, of whom 235,841 (53.26 %) were women. Those dispensed antineoplastic medications during 2012-2013 had low...

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Veröffentlicht in:Maturitas 2024-02, Vol.180, p.107888-107888, Article 107888
Hauptverfasser: Almeida, Osvaldo P, Etherton-Beer, Christopher, Sanfilippo, Frank, Preen, David B, Page, Amy
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer Disease - drug therapy
Antineoplastic Agents - therapeutic use
Cholinesterase Inhibitors - therapeutic use
Cohort Studies
Dementia - drug therapy
Female
Humans
Male
Memantine - therapeutic use
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container_end_page 107888
container_issue
container_start_page 107888
container_title Maturitas
container_volume 180
creator Almeida, Osvaldo P
Etherton-Beer, Christopher
Sanfilippo, Frank
Preen, David B
Page, Amy
description History of cancer has been associated with decreased risk of dementia, but it is unclear if this is due to the use of antineoplastic medications. Participants were 442,795 adults aged ≥60 years, of whom 235,841 (53.26 %) were women. Those dispensed antineoplastic medications during 2012-2013 had lower odds of being dispensed an anti-dementia drug between 2015 and 2021 (age/sex-adjusted OR = 0.60, 95%CI = 0.55-0.66). The dispensing of antineoplastic medications was associated with an adjusted hazard ratio of 0.72 (95%CI = 0.65-0.80) of subsequent dispensing of an anti-dementia drug. Understanding the mechanisms that support this association may contribute to the introduction of novel approaches to dementia prevention.
doi_str_mv 10.1016/j.maturitas.2023.107888
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source MEDLINE; Elsevier ScienceDirect Journals Complete
subjects Alzheimer Disease - drug therapy
Antineoplastic Agents - therapeutic use
Cholinesterase Inhibitors - therapeutic use
Cohort Studies
Dementia - drug therapy
Female
Humans
Male
Memantine - therapeutic use
title Dispensing of antineoplastic medications and their impact on the dispensing of anti-dementia drugs for adults aged ≥60 years: A cohort study
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