Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies

CCS1477 (inobrodib) is a potent, selective EP300/CBP bromodomain inhibitor which induces cell-cycle arrest and differentiation in hematologic malignancy model systems. In myeloid leukemia cells, it promotes rapid eviction of EP300/CBP from an enhancer subset marked by strong MYB occupancy and high H...

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Veröffentlicht in:	Cancer cell 2023-12, Vol.41 (12), p.2136-2153.e13
Hauptverfasser:	Nicosia, Luciano, Spencer, Gary J, Brooks, Nigel, Amaral, Fabio M R, Basma, Naseer J, Chadwick, John A, Revell, Bradley, Wingelhofer, Bettina, Maiques-Diaz, Alba, Sinclair, Oliver, Camera, Francesco, Ciceri, Filippo, Wiseman, Daniel H, Pegg, Neil, West, Will, Knurowski, Tomasz, Frese, Kris, Clegg, Karen, Campbell, Victoria L, Cavet, James, Copland, Mhairi, Searle, Emma, Somervaille, Tim C P
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor E1A-Associated p300 Protein Hematologic Neoplasms - drug therapy Hematologic Neoplasms - genetics Humans Nuclear Proteins Protein Domains Transcription Factors
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