Potential mechanisms underlying the effect of hepatocyte growth factor on liver injury in short bowel syndrome model rats

Potential mechanisms underlying the effect of hepatocyte growth factor on liver injury in short bowel syndrome model rats

Purpose The purpose of this study was to investigate the autophagy associated with apoptosis in hepatic damage in the short bowel syndrome rat model. Methods SD rats underwent jugular vein catheterization for continuous total parenteral nutrition (TPN) and 90% small bowel resection. Animals were div...

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Veröffentlicht in:Pediatric surgery international 2023-11, Vol.40 (1), p.8-8, Article 8
Hauptverfasser: Sugita, Koshiro, Yano, Keisuke, Matsukubo, Makoto, Iwamoto, Yumiko, Ogata, Masato, Takada, Lynne, Kedoin, Chihiro, Murakami, Masakazu, Harumatsu, Toshio, Onishi, Shun, Kawano, Takafumi, Muto, Mitsuru, Kumagai, Kotaro, Ido, Akio, Kaji, Tatsuru, Ieiri, Satoshi
Format: Artikel
Sprache:eng
Schlagworte:
Growth factors
Medicine
Medicine & Public Health
Original Article
Pediatric Surgery
Pediatrics
Surgery
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Zusammenfassung:Purpose The purpose of this study was to investigate the autophagy associated with apoptosis in hepatic damage in the short bowel syndrome rat model. Methods SD rats underwent jugular vein catheterization for continuous total parenteral nutrition (TPN) and 90% small bowel resection. Animals were divided into two groups: TPN plus SBS (Control group) or TPN plus SBS plus intravenous administration of HGF (HGF group). On day 7, the rats were harvested, and hepatocellular injury was evaluated. Results In an SBS rat model, hepatic steatosis and lobular inflammation were histologically suppressed in the HGF group ( p  
ISSN:1437-9813
0179-0358
1437-9813
DOI:10.1007/s00383-023-05593-w