Microglial activation and toll-like receptor 4-Dependent regulation of angiotensin II type I receptor-mu-opioid receptor 1 heterodimerization and hypertension in fructose-fed rats

Our previous study reported that the heterodimer of Angiotensin II Type I Receptor (AT1R) and Mu-Opioid Receptor 1 (MOR1) involves Nitric Oxide (NO) reduction which leads to elevation of blood pressure. Secondly, we showed that Toll-like Receptor 4 (TLR4) may be involved in the heterodimerization of...

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Veröffentlicht in:	European journal of pharmacology 2024-01, Vol.962, p.176171-176171, Article 176171
Hauptverfasser:	Ho, Chiu-Yi, Sun, Gwo-Ching, Lin, Yu-Te, Wong, Tzyy-Yue, Hsiao, Michael, Tseng, Ching-Jiunn, Cheng, Pei-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Animals Blood Pressure Fructose Hypertension Microglia - metabolism Neuroinflammatory Diseases Nitric Oxide - metabolism Polyesters Rats Receptor, Angiotensin, Type 1 - metabolism Receptors, Opioid - metabolism Solitary Nucleus Toll-Like Receptor 4 - metabolism
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