PCSK9 and leptin plasma levels in anorexia nervosa
Aim Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a regulator of low-density-lipoprotein cholesterol (LDL-C), a major risk factor for cardiovascular (CV) disease. Since the hormone leptin has been suggested as having a role in CV risk regulation, possibly by modulating LDL receptor expres...
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| Veröffentlicht in: | Hormones (Athens, Greece) Greece), 2024-03, Vol.23 (1), p.137-140 |
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| creator | Bigazzi, Federico De Pasquale, Carlotta Francesca Maestro, Sandra Corciulo, Carmen Dal Pino, Beatrice Sbrana, Francesco Sampietro, Tiziana |
| description | Aim
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a regulator of low-density-lipoprotein cholesterol (LDL-C), a major risk factor for cardiovascular (CV) disease. Since the hormone leptin has been suggested as having a role in CV risk regulation, possibly by modulating LDL receptor expression through the PCSK9 pathway, nutritional status may represent a potential regulator. Thus, evaluation of PCSK9 levels in human eating disorders appears to be of interest. In this report, we evaluate the lipoprotein profile, PCSK9, and leptin levels in subjects affected by anorexia nervosa (AN) to improve our understanding of the metabolic alterations in this disease.
Methods and results
We designed a case-control observational study, enrolling 20 anorexic adolescent females and 20 adolescent females without AN as the control group, age- and sex-matched. Subjects affected by AN showed lower BMI, total cholesterol, and LDL-C in comparison to the control group, with lipoprotein levels in the normal range. Furthermore, adolescent girls with AN show significantly higher PCSK9 (+24%,
p
< 0.005) and lower leptin levels (−43%,
p
< 0.01), compared to the control group.
Conclusions
The findings of increased levels of PCSK9 and reduced leptin levels among AN subjects warrant further research in order to unravel the role of the liver and adipose tissue in the management of PCSK9/LDL metabolism in adolescents affected by AN. |
| doi_str_mv | 10.1007/s42000-023-00504-z |
| format | Article |
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Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a regulator of low-density-lipoprotein cholesterol (LDL-C), a major risk factor for cardiovascular (CV) disease. Since the hormone leptin has been suggested as having a role in CV risk regulation, possibly by modulating LDL receptor expression through the PCSK9 pathway, nutritional status may represent a potential regulator. Thus, evaluation of PCSK9 levels in human eating disorders appears to be of interest. In this report, we evaluate the lipoprotein profile, PCSK9, and leptin levels in subjects affected by anorexia nervosa (AN) to improve our understanding of the metabolic alterations in this disease.
Methods and results
We designed a case-control observational study, enrolling 20 anorexic adolescent females and 20 adolescent females without AN as the control group, age- and sex-matched. Subjects affected by AN showed lower BMI, total cholesterol, and LDL-C in comparison to the control group, with lipoprotein levels in the normal range. Furthermore, adolescent girls with AN show significantly higher PCSK9 (+24%,
p
< 0.005) and lower leptin levels (−43%,
p
< 0.01), compared to the control group.
Conclusions
The findings of increased levels of PCSK9 and reduced leptin levels among AN subjects warrant further research in order to unravel the role of the liver and adipose tissue in the management of PCSK9/LDL metabolism in adolescents affected by AN.</description><identifier>ISSN: 1109-3099</identifier><identifier>EISSN: 2520-8721</identifier><identifier>DOI: 10.1007/s42000-023-00504-z</identifier><identifier>PMID: 37999906</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Endocrinology ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Original Article</subject><ispartof>Hormones (Athens, Greece), 2024-03, Vol.23 (1), p.137-140</ispartof><rights>The Author(s), under exclusive licence to Hellenic Endocrine Society 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Hellenic Endocrine Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-d49e17006db1b00b927dfcb880a6cb16d096e5dbac8e648eb84c77eff8cf0c3a3</citedby><cites>FETCH-LOGICAL-c347t-d49e17006db1b00b927dfcb880a6cb16d096e5dbac8e648eb84c77eff8cf0c3a3</cites><orcidid>0000-0003-4607-0373</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s42000-023-00504-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s42000-023-00504-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37999906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bigazzi, Federico</creatorcontrib><creatorcontrib>De Pasquale, Carlotta Francesca</creatorcontrib><creatorcontrib>Maestro, Sandra</creatorcontrib><creatorcontrib>Corciulo, Carmen</creatorcontrib><creatorcontrib>Dal Pino, Beatrice</creatorcontrib><creatorcontrib>Sbrana, Francesco</creatorcontrib><creatorcontrib>Sampietro, Tiziana</creatorcontrib><title>PCSK9 and leptin plasma levels in anorexia nervosa</title><title>Hormones (Athens, Greece)</title><addtitle>Hormones</addtitle><addtitle>Hormones (Athens)</addtitle><description>Aim
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a regulator of low-density-lipoprotein cholesterol (LDL-C), a major risk factor for cardiovascular (CV) disease. Since the hormone leptin has been suggested as having a role in CV risk regulation, possibly by modulating LDL receptor expression through the PCSK9 pathway, nutritional status may represent a potential regulator. Thus, evaluation of PCSK9 levels in human eating disorders appears to be of interest. In this report, we evaluate the lipoprotein profile, PCSK9, and leptin levels in subjects affected by anorexia nervosa (AN) to improve our understanding of the metabolic alterations in this disease.
Methods and results
We designed a case-control observational study, enrolling 20 anorexic adolescent females and 20 adolescent females without AN as the control group, age- and sex-matched. Subjects affected by AN showed lower BMI, total cholesterol, and LDL-C in comparison to the control group, with lipoprotein levels in the normal range. Furthermore, adolescent girls with AN show significantly higher PCSK9 (+24%,
p
< 0.005) and lower leptin levels (−43%,
p
< 0.01), compared to the control group.
Conclusions
The findings of increased levels of PCSK9 and reduced leptin levels among AN subjects warrant further research in order to unravel the role of the liver and adipose tissue in the management of PCSK9/LDL metabolism in adolescents affected by AN.</description><subject>Endocrinology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Original Article</subject><issn>1109-3099</issn><issn>2520-8721</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PwzAMhiMEYmPwBzigHrkEnKRtkiOa-BKTQALOUZq6qFO_SNYJ9usJbHDEF8v269fyQ8gpgwsGIC9DygGAAhcUIIOUbvbIlGccqJKc7ZMpY6CpAK0n5CiEJUCeacUOyURIHQPyKeFP8-cHndiuTBocVnWXDI0NrY3VGpuQxIbteo8ftU069Os-2GNyUNkm4Mkuz8jrzfXL_I4uHm_v51cL6kQqV7RMNTIZb5YFKwAKzWVZuUIpsLkrWF6CzjErC-sU5qnCQqVOSqwq5SpwwooZOd_6Dr5_HzGsTFsHh01jO-zHYLjSQqUAmkcp30qd70PwWJnB1631n4aB-WZltqxMZGV-WJlNXDrb-Y9Fi-Xfyi-cKBBbQYij7g29Wfaj7-LP_9l-AXtzdIE</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Bigazzi, Federico</creator><creator>De Pasquale, Carlotta Francesca</creator><creator>Maestro, Sandra</creator><creator>Corciulo, Carmen</creator><creator>Dal Pino, Beatrice</creator><creator>Sbrana, Francesco</creator><creator>Sampietro, Tiziana</creator><general>Springer International Publishing</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4607-0373</orcidid></search><sort><creationdate>20240301</creationdate><title>PCSK9 and leptin plasma levels in anorexia nervosa</title><author>Bigazzi, Federico ; De Pasquale, Carlotta Francesca ; Maestro, Sandra ; Corciulo, Carmen ; Dal Pino, Beatrice ; Sbrana, Francesco ; Sampietro, Tiziana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-d49e17006db1b00b927dfcb880a6cb16d096e5dbac8e648eb84c77eff8cf0c3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Endocrinology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Original Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bigazzi, Federico</creatorcontrib><creatorcontrib>De Pasquale, Carlotta Francesca</creatorcontrib><creatorcontrib>Maestro, Sandra</creatorcontrib><creatorcontrib>Corciulo, Carmen</creatorcontrib><creatorcontrib>Dal Pino, Beatrice</creatorcontrib><creatorcontrib>Sbrana, Francesco</creatorcontrib><creatorcontrib>Sampietro, Tiziana</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hormones (Athens, Greece)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bigazzi, Federico</au><au>De Pasquale, Carlotta Francesca</au><au>Maestro, Sandra</au><au>Corciulo, Carmen</au><au>Dal Pino, Beatrice</au><au>Sbrana, Francesco</au><au>Sampietro, Tiziana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PCSK9 and leptin plasma levels in anorexia nervosa</atitle><jtitle>Hormones (Athens, Greece)</jtitle><stitle>Hormones</stitle><addtitle>Hormones (Athens)</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>23</volume><issue>1</issue><spage>137</spage><epage>140</epage><pages>137-140</pages><issn>1109-3099</issn><eissn>2520-8721</eissn><abstract>Aim
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a regulator of low-density-lipoprotein cholesterol (LDL-C), a major risk factor for cardiovascular (CV) disease. Since the hormone leptin has been suggested as having a role in CV risk regulation, possibly by modulating LDL receptor expression through the PCSK9 pathway, nutritional status may represent a potential regulator. Thus, evaluation of PCSK9 levels in human eating disorders appears to be of interest. In this report, we evaluate the lipoprotein profile, PCSK9, and leptin levels in subjects affected by anorexia nervosa (AN) to improve our understanding of the metabolic alterations in this disease.
Methods and results
We designed a case-control observational study, enrolling 20 anorexic adolescent females and 20 adolescent females without AN as the control group, age- and sex-matched. Subjects affected by AN showed lower BMI, total cholesterol, and LDL-C in comparison to the control group, with lipoprotein levels in the normal range. Furthermore, adolescent girls with AN show significantly higher PCSK9 (+24%,
p
< 0.005) and lower leptin levels (−43%,
p
< 0.01), compared to the control group.
Conclusions
The findings of increased levels of PCSK9 and reduced leptin levels among AN subjects warrant further research in order to unravel the role of the liver and adipose tissue in the management of PCSK9/LDL metabolism in adolescents affected by AN.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>37999906</pmid><doi>10.1007/s42000-023-00504-z</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-4607-0373</orcidid></addata></record> |
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| subjects | Endocrinology Medicine Medicine & Public Health Metabolic Diseases Original Article |
| title | PCSK9 and leptin plasma levels in anorexia nervosa |
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