Peroxidasin is required for full viability in development and for maintenance of tissue mechanics in adults

•Th collagen IV NC1 crosslinking enzyme Peroxidasin is highly conserved.•Mutants in flies and mice are lethal with viable escapers.•NC1 crosslinking occurs at low levels in Peroxidasin null mutants.•Fly null mutant escapers have defective mechanics in several tissues.•Adult basement membranes need c...

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Veröffentlicht in:	Matrix biology 2024-01, Vol.125, p.1-11
Hauptverfasser:	Peebles, K. Elkie, LaFever, Kimberly S., Page-McCaw, Patrick S., Colon, Selene, Wang, Dan, Stricker, Aubrie M., Ferrell, Nicholas, Bhave, Gautam, Page-McCaw, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basal lamina Basement Membrane - metabolism Collagen Type IV - metabolism Drosophila - metabolism Dynamics Extracellular matrix Extracellular Matrix - genetics Extracellular Matrix - metabolism Extracellular Matrix Proteins - metabolism Homeostasis Mice Peroxidase - genetics Peroxidasin Sulfilimine bond Tensile stiffness
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