Evaluation of lung volumes and gas exchange in surfactant-deficient rabbits between variable and fixed servo pressures during high-frequency jet ventilation
Objective To investigate a novel servo pressure (SP) setting during high-frequency jet ventilation (HFJV) for a lung protective strategy in a neonatal model of acute respiratory distress. Study design Comparison of efficacy between variable (standard) and fixed SP settings in a randomized animal stu...
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| Veröffentlicht in: | Journal of perinatology 2024-02, Vol.44 (2), p.266-272 |
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| creator | DiBlasi, Robert M. Micheletti, Kellie J. Romo, Tina Malone, Patrik Orth, Jeff Richards, Evan Kajimoto, Masaki Goldstein, Justin R. Keszler, Martin |
| description | Objective
To investigate a novel servo pressure (SP) setting during high-frequency jet ventilation (HFJV) for a lung protective strategy in a neonatal model of acute respiratory distress.
Study design
Comparison of efficacy between variable (standard) and fixed SP settings in a randomized animal study using rabbits (
n
= 10, mean weight = 1.80 kg) with surfactant deficiency by repeated lung lavages.
Results
Rabbits in the fixed SP group had greater peak inspiratory pressure, SP, minute volume, pH, and PaO
2
, and lower PaCO
2
after lung lavage than the variable SP group. Lung volume monitoring with electrical impedance tomography showed that fixed SP reduced the decline of the global lung tidal variation at 30 min after lung lavage (−17.4% from baseline before lavage) compared to variable SP (−44.9%).
Conclusion
HFJV with fixed SP significantly improved gas exchange and lung volumes compared to variable SP. Applying a fixed SP may have important clinical implications for patients receiving HFJV. |
| doi_str_mv | 10.1038/s41372-023-01832-z |
| format | Article |
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To investigate a novel servo pressure (SP) setting during high-frequency jet ventilation (HFJV) for a lung protective strategy in a neonatal model of acute respiratory distress.
Study design
Comparison of efficacy between variable (standard) and fixed SP settings in a randomized animal study using rabbits (
n
= 10, mean weight = 1.80 kg) with surfactant deficiency by repeated lung lavages.
Results
Rabbits in the fixed SP group had greater peak inspiratory pressure, SP, minute volume, pH, and PaO
2
, and lower PaCO
2
after lung lavage than the variable SP group. Lung volume monitoring with electrical impedance tomography showed that fixed SP reduced the decline of the global lung tidal variation at 30 min after lung lavage (−17.4% from baseline before lavage) compared to variable SP (−44.9%).
Conclusion
HFJV with fixed SP significantly improved gas exchange and lung volumes compared to variable SP. Applying a fixed SP may have important clinical implications for patients receiving HFJV.</description><identifier>ISSN: 0743-8346</identifier><identifier>ISSN: 1476-5543</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/s41372-023-01832-z</identifier><identifier>PMID: 38007593</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/443 ; 692/308/575 ; 692/700 ; Animals ; Blood pressure ; Electrical impedance ; Gas exchange ; Gases ; Heart rate ; High-Frequency Jet Ventilation ; High-Frequency Ventilation ; Humans ; Ketamine ; Lavage ; Lung ; Lung Volume Measurements ; Lungs ; Mechanics ; Medicine ; Medicine & Public Health ; Neonates ; Pediatric Surgery ; Pediatrics ; Pulmonary Surfactants ; Rabbits ; Respiration ; Respiration, Artificial - methods ; Respiratory distress syndrome ; Surface-Active Agents ; Surfactants ; Tomography ; Ventilation ; Ventilators</subject><ispartof>Journal of perinatology, 2024-02, Vol.44 (2), p.266-272</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-7bc0d2c10fe0515e10d5491fb7a118571027bb8c60413b6fa104d47f28d265723</cites><orcidid>0000-0001-9377-1354 ; 0000-0002-9964-664X ; 0000-0002-9206-7346</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41372-023-01832-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41372-023-01832-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38007593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DiBlasi, Robert M.</creatorcontrib><creatorcontrib>Micheletti, Kellie J.</creatorcontrib><creatorcontrib>Romo, Tina</creatorcontrib><creatorcontrib>Malone, Patrik</creatorcontrib><creatorcontrib>Orth, Jeff</creatorcontrib><creatorcontrib>Richards, Evan</creatorcontrib><creatorcontrib>Kajimoto, Masaki</creatorcontrib><creatorcontrib>Goldstein, Justin R.</creatorcontrib><creatorcontrib>Keszler, Martin</creatorcontrib><title>Evaluation of lung volumes and gas exchange in surfactant-deficient rabbits between variable and fixed servo pressures during high-frequency jet ventilation</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective
To investigate a novel servo pressure (SP) setting during high-frequency jet ventilation (HFJV) for a lung protective strategy in a neonatal model of acute respiratory distress.
Study design
Comparison of efficacy between variable (standard) and fixed SP settings in a randomized animal study using rabbits (
n
= 10, mean weight = 1.80 kg) with surfactant deficiency by repeated lung lavages.
Results
Rabbits in the fixed SP group had greater peak inspiratory pressure, SP, minute volume, pH, and PaO
2
, and lower PaCO
2
after lung lavage than the variable SP group. Lung volume monitoring with electrical impedance tomography showed that fixed SP reduced the decline of the global lung tidal variation at 30 min after lung lavage (−17.4% from baseline before lavage) compared to variable SP (−44.9%).
Conclusion
HFJV with fixed SP significantly improved gas exchange and lung volumes compared to variable SP. Applying a fixed SP may have important clinical implications for patients receiving HFJV.</description><subject>631/443</subject><subject>692/308/575</subject><subject>692/700</subject><subject>Animals</subject><subject>Blood pressure</subject><subject>Electrical impedance</subject><subject>Gas exchange</subject><subject>Gases</subject><subject>Heart rate</subject><subject>High-Frequency Jet Ventilation</subject><subject>High-Frequency Ventilation</subject><subject>Humans</subject><subject>Ketamine</subject><subject>Lavage</subject><subject>Lung</subject><subject>Lung Volume Measurements</subject><subject>Lungs</subject><subject>Mechanics</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neonates</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Pulmonary Surfactants</subject><subject>Rabbits</subject><subject>Respiration</subject><subject>Respiration, Artificial - methods</subject><subject>Respiratory distress 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Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of lung volumes and gas exchange in surfactant-deficient rabbits between variable and fixed servo pressures during high-frequency jet ventilation</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2024-02-01</date><risdate>2024</risdate><volume>44</volume><issue>2</issue><spage>266</spage><epage>272</epage><pages>266-272</pages><issn>0743-8346</issn><issn>1476-5543</issn><eissn>1476-5543</eissn><abstract>Objective
To investigate a novel servo pressure (SP) setting during high-frequency jet ventilation (HFJV) for a lung protective strategy in a neonatal model of acute respiratory distress.
Study design
Comparison of efficacy between variable (standard) and fixed SP settings in a randomized animal study using rabbits (
n
= 10, mean weight = 1.80 kg) with surfactant deficiency by repeated lung lavages.
Results
Rabbits in the fixed SP group had greater peak inspiratory pressure, SP, minute volume, pH, and PaO
2
, and lower PaCO
2
after lung lavage than the variable SP group. Lung volume monitoring with electrical impedance tomography showed that fixed SP reduced the decline of the global lung tidal variation at 30 min after lung lavage (−17.4% from baseline before lavage) compared to variable SP (−44.9%).
Conclusion
HFJV with fixed SP significantly improved gas exchange and lung volumes compared to variable SP. Applying a fixed SP may have important clinical implications for patients receiving HFJV.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>38007593</pmid><doi>10.1038/s41372-023-01832-z</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-9377-1354</orcidid><orcidid>https://orcid.org/0000-0002-9964-664X</orcidid><orcidid>https://orcid.org/0000-0002-9206-7346</orcidid></addata></record> |
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| identifier | ISSN: 0743-8346 |
| ispartof | Journal of perinatology, 2024-02, Vol.44 (2), p.266-272 |
| issn | 0743-8346 1476-5543 1476-5543 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | 631/443 692/308/575 692/700 Animals Blood pressure Electrical impedance Gas exchange Gases Heart rate High-Frequency Jet Ventilation High-Frequency Ventilation Humans Ketamine Lavage Lung Lung Volume Measurements Lungs Mechanics Medicine Medicine & Public Health Neonates Pediatric Surgery Pediatrics Pulmonary Surfactants Rabbits Respiration Respiration, Artificial - methods Respiratory distress syndrome Surface-Active Agents Surfactants Tomography Ventilation Ventilators |
| title | Evaluation of lung volumes and gas exchange in surfactant-deficient rabbits between variable and fixed servo pressures during high-frequency jet ventilation |
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