Surface-Modified Lyotropic Crystalline Nanoconstructs Bearing Doxorubicin and Buparvaquone Target Sigma Receptors through pH-Sensitive Charge Conversion to Improve Breast Cancer Therapy

In the current study, we aimed to develop lyotropic crystalline nanoconstructs (LCNs) based on poly­(l-glutamic acid) (PLG) with a two-tier strategy. The first objective was to confer pH-responsive charge conversion properties to facilitate the delivery of both doxorubicin (DOX) and buparvaquone (BP...

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Veröffentlicht in:	Biomacromolecules 2023-12, Vol.24 (12), p.5780-5796
Hauptverfasser:	Singh, Neha, Marwaha, Disha, Gautam, Shalini, Rai, Nikhil, Tiwari, Pratiksha, Sharma, Madhu, Shukla, Ravi Prakash, Mugale, Madhav Nilakanth, Kumar, Akhilesh, Mishra, Prabhat Ranjan
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - drug therapy Doxorubicin - chemistry Drug Carriers - chemistry Female Glutamic Acid Humans Hydrogen-Ion Concentration Nanoparticles - chemistry Receptors, sigma - therapeutic use Scattering, Small Angle Tumor Microenvironment X-Ray Diffraction
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