Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study

Background: To compare corneal densitometry (CD) patterns at the graft–host interface between Descemet Membrane Endothelial Keratoplasty (DMEK) and Descemet Stripping Automated Endothelial Keratoplasty (DSAEK). Corneal densitometry is a quantitative assessment that objectively evaluates corneal clar...

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Veröffentlicht in:Journal of clinical medicine 2023-11, Vol.12 (22), p.7133
Hauptverfasser: Ballesteros-Sánchez, Antonio, Peraza-Nieves, Jorge, Casablanca-Piñera, Anna, Rodríguez-Calvo-De-Mora, Marina, Catalán-Coronado, Saray, Torras-Sanvicens, Josep, Borroni, Davide, Sánchez-González, José-María, Rocha-De-Lossada, Carlos
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container_issue 22
container_start_page 7133
container_title Journal of clinical medicine
container_volume 12
creator Ballesteros-Sánchez, Antonio
Peraza-Nieves, Jorge
Casablanca-Piñera, Anna
Rodríguez-Calvo-De-Mora, Marina
Catalán-Coronado, Saray
Torras-Sanvicens, Josep
Borroni, Davide
Sánchez-González, José-María
Rocha-De-Lossada, Carlos
description Background: To compare corneal densitometry (CD) patterns at the graft–host interface between Descemet Membrane Endothelial Keratoplasty (DMEK) and Descemet Stripping Automated Endothelial Keratoplasty (DSAEK). Corneal densitometry is a quantitative assessment that objectively evaluates corneal clarity and optical quality by measuring the light backscatter from the cornea. Methods: Fifty-one eyes that received DMEK or DSAEK surgery for corneal endothelium dysfunction were evaluated. The primary endpoint included CD patterns at the graft–host interface, which were assessed by the Pentacam HR device at the center point of the corneal horizontal meridian (CDcentral), and at six points on the central circumference of the cornea (with a total diameter of 4 mm) (CDI,II,III,IV,V,VI). Secondary endpoints included the best-corrected distance visual acuity (BCDVA), central corneal thickness (CCT), and graft thickness (GT). All of the evaluations were performed at follow-up appointments one, three, six and twelve months after the procedure. Results: DMEK showed a significant overall CD reduction of −7.9 ± 8.5 grayscale unit (GSU) compared to DSAEK (p < 0.001). In addition, the DMEK group showed significantly lower CDCentral,I,II,III,IV,V,VI values at follow-up appointments one, three, six and twelve months after the procedure compared to the DSAEK group (p < 0.001). BCDVA, CCT and GT were in favor of the DMEK group with a mean value of 0.39 ± 0.35 LogMar, 552.2 ± 71.1 µm and 11.03 ± 1.4 µm, respectively (p < 0.001). Conclusions: CD patterns at the graft–host interface seem to be different depending on the endothelial keratoplasty procedure. This provides specific insight into CD changes in this critical region of surgery, which may provide a better understanding of the postoperative evolution of these patients.
doi_str_mv 10.3390/jcm12227133
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Corneal densitometry is a quantitative assessment that objectively evaluates corneal clarity and optical quality by measuring the light backscatter from the cornea. Methods: Fifty-one eyes that received DMEK or DSAEK surgery for corneal endothelium dysfunction were evaluated. The primary endpoint included CD patterns at the graft–host interface, which were assessed by the Pentacam HR device at the center point of the corneal horizontal meridian (CDcentral), and at six points on the central circumference of the cornea (with a total diameter of 4 mm) (CDI,II,III,IV,V,VI). Secondary endpoints included the best-corrected distance visual acuity (BCDVA), central corneal thickness (CCT), and graft thickness (GT). All of the evaluations were performed at follow-up appointments one, three, six and twelve months after the procedure. Results: DMEK showed a significant overall CD reduction of −7.9 ± 8.5 grayscale unit (GSU) compared to DSAEK (p &lt; 0.001). In addition, the DMEK group showed significantly lower CDCentral,I,II,III,IV,V,VI values at follow-up appointments one, three, six and twelve months after the procedure compared to the DSAEK group (p &lt; 0.001). BCDVA, CCT and GT were in favor of the DMEK group with a mean value of 0.39 ± 0.35 LogMar, 552.2 ± 71.1 µm and 11.03 ± 1.4 µm, respectively (p &lt; 0.001). Conclusions: CD patterns at the graft–host interface seem to be different depending on the endothelial keratoplasty procedure. This provides specific insight into CD changes in this critical region of surgery, which may provide a better understanding of the postoperative evolution of these patients.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12227133</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Clinical medicine ; Cornea ; Corneal transplantation ; Endothelium ; Eye surgery ; Graft versus host reaction ; Hospitals ; Light ; Patients ; Risk factors ; Surgeons ; Surgical outcomes ; Transplantation ; Variables ; Visual acuity</subject><ispartof>Journal of clinical medicine, 2023-11, Vol.12 (22), p.7133</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-fef0838b0e3866ad0250b74b4cf82fbc30c29225e303ef7feca8bf509200e5673</citedby><cites>FETCH-LOGICAL-c398t-fef0838b0e3866ad0250b74b4cf82fbc30c29225e303ef7feca8bf509200e5673</cites><orcidid>0000-0002-9248-8685 ; 0000-0001-6952-5647 ; 0000-0001-7464-2493 ; 0000-0002-3950-1828 ; 0000-0001-6995-1291 ; 0000-0003-0450-7717</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Ballesteros-Sánchez, Antonio</creatorcontrib><creatorcontrib>Peraza-Nieves, Jorge</creatorcontrib><creatorcontrib>Casablanca-Piñera, Anna</creatorcontrib><creatorcontrib>Rodríguez-Calvo-De-Mora, Marina</creatorcontrib><creatorcontrib>Catalán-Coronado, Saray</creatorcontrib><creatorcontrib>Torras-Sanvicens, Josep</creatorcontrib><creatorcontrib>Borroni, Davide</creatorcontrib><creatorcontrib>Sánchez-González, José-María</creatorcontrib><creatorcontrib>Rocha-De-Lossada, Carlos</creatorcontrib><title>Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study</title><title>Journal of clinical medicine</title><description>Background: To compare corneal densitometry (CD) patterns at the graft–host interface between Descemet Membrane Endothelial Keratoplasty (DMEK) and Descemet Stripping Automated Endothelial Keratoplasty (DSAEK). Corneal densitometry is a quantitative assessment that objectively evaluates corneal clarity and optical quality by measuring the light backscatter from the cornea. Methods: Fifty-one eyes that received DMEK or DSAEK surgery for corneal endothelium dysfunction were evaluated. The primary endpoint included CD patterns at the graft–host interface, which were assessed by the Pentacam HR device at the center point of the corneal horizontal meridian (CDcentral), and at six points on the central circumference of the cornea (with a total diameter of 4 mm) (CDI,II,III,IV,V,VI). Secondary endpoints included the best-corrected distance visual acuity (BCDVA), central corneal thickness (CCT), and graft thickness (GT). All of the evaluations were performed at follow-up appointments one, three, six and twelve months after the procedure. Results: DMEK showed a significant overall CD reduction of −7.9 ± 8.5 grayscale unit (GSU) compared to DSAEK (p &lt; 0.001). In addition, the DMEK group showed significantly lower CDCentral,I,II,III,IV,V,VI values at follow-up appointments one, three, six and twelve months after the procedure compared to the DSAEK group (p &lt; 0.001). BCDVA, CCT and GT were in favor of the DMEK group with a mean value of 0.39 ± 0.35 LogMar, 552.2 ± 71.1 µm and 11.03 ± 1.4 µm, respectively (p &lt; 0.001). Conclusions: CD patterns at the graft–host interface seem to be different depending on the endothelial keratoplasty procedure. 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Corneal densitometry is a quantitative assessment that objectively evaluates corneal clarity and optical quality by measuring the light backscatter from the cornea. Methods: Fifty-one eyes that received DMEK or DSAEK surgery for corneal endothelium dysfunction were evaluated. The primary endpoint included CD patterns at the graft–host interface, which were assessed by the Pentacam HR device at the center point of the corneal horizontal meridian (CDcentral), and at six points on the central circumference of the cornea (with a total diameter of 4 mm) (CDI,II,III,IV,V,VI). Secondary endpoints included the best-corrected distance visual acuity (BCDVA), central corneal thickness (CCT), and graft thickness (GT). All of the evaluations were performed at follow-up appointments one, three, six and twelve months after the procedure. Results: DMEK showed a significant overall CD reduction of −7.9 ± 8.5 grayscale unit (GSU) compared to DSAEK (p &lt; 0.001). In addition, the DMEK group showed significantly lower CDCentral,I,II,III,IV,V,VI values at follow-up appointments one, three, six and twelve months after the procedure compared to the DSAEK group (p &lt; 0.001). BCDVA, CCT and GT were in favor of the DMEK group with a mean value of 0.39 ± 0.35 LogMar, 552.2 ± 71.1 µm and 11.03 ± 1.4 µm, respectively (p &lt; 0.001). Conclusions: CD patterns at the graft–host interface seem to be different depending on the endothelial keratoplasty procedure. 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subjects Clinical medicine
Cornea
Corneal transplantation
Endothelium
Eye surgery
Graft versus host reaction
Hospitals
Light
Patients
Risk factors
Surgeons
Surgical outcomes
Transplantation
Variables
Visual acuity
title Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study
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