Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study
Background: To compare corneal densitometry (CD) patterns at the graft–host interface between Descemet Membrane Endothelial Keratoplasty (DMEK) and Descemet Stripping Automated Endothelial Keratoplasty (DSAEK). Corneal densitometry is a quantitative assessment that objectively evaluates corneal clar...
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creator | Ballesteros-Sánchez, Antonio Peraza-Nieves, Jorge Casablanca-Piñera, Anna Rodríguez-Calvo-De-Mora, Marina Catalán-Coronado, Saray Torras-Sanvicens, Josep Borroni, Davide Sánchez-González, José-María Rocha-De-Lossada, Carlos |
description | Background: To compare corneal densitometry (CD) patterns at the graft–host interface between Descemet Membrane Endothelial Keratoplasty (DMEK) and Descemet Stripping Automated Endothelial Keratoplasty (DSAEK). Corneal densitometry is a quantitative assessment that objectively evaluates corneal clarity and optical quality by measuring the light backscatter from the cornea. Methods: Fifty-one eyes that received DMEK or DSAEK surgery for corneal endothelium dysfunction were evaluated. The primary endpoint included CD patterns at the graft–host interface, which were assessed by the Pentacam HR device at the center point of the corneal horizontal meridian (CDcentral), and at six points on the central circumference of the cornea (with a total diameter of 4 mm) (CDI,II,III,IV,V,VI). Secondary endpoints included the best-corrected distance visual acuity (BCDVA), central corneal thickness (CCT), and graft thickness (GT). All of the evaluations were performed at follow-up appointments one, three, six and twelve months after the procedure. Results: DMEK showed a significant overall CD reduction of −7.9 ± 8.5 grayscale unit (GSU) compared to DSAEK (p < 0.001). In addition, the DMEK group showed significantly lower CDCentral,I,II,III,IV,V,VI values at follow-up appointments one, three, six and twelve months after the procedure compared to the DSAEK group (p < 0.001). BCDVA, CCT and GT were in favor of the DMEK group with a mean value of 0.39 ± 0.35 LogMar, 552.2 ± 71.1 µm and 11.03 ± 1.4 µm, respectively (p < 0.001). Conclusions: CD patterns at the graft–host interface seem to be different depending on the endothelial keratoplasty procedure. This provides specific insight into CD changes in this critical region of surgery, which may provide a better understanding of the postoperative evolution of these patients. |
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Corneal densitometry is a quantitative assessment that objectively evaluates corneal clarity and optical quality by measuring the light backscatter from the cornea. Methods: Fifty-one eyes that received DMEK or DSAEK surgery for corneal endothelium dysfunction were evaluated. The primary endpoint included CD patterns at the graft–host interface, which were assessed by the Pentacam HR device at the center point of the corneal horizontal meridian (CDcentral), and at six points on the central circumference of the cornea (with a total diameter of 4 mm) (CDI,II,III,IV,V,VI). Secondary endpoints included the best-corrected distance visual acuity (BCDVA), central corneal thickness (CCT), and graft thickness (GT). All of the evaluations were performed at follow-up appointments one, three, six and twelve months after the procedure. Results: DMEK showed a significant overall CD reduction of −7.9 ± 8.5 grayscale unit (GSU) compared to DSAEK (p < 0.001). In addition, the DMEK group showed significantly lower CDCentral,I,II,III,IV,V,VI values at follow-up appointments one, three, six and twelve months after the procedure compared to the DSAEK group (p < 0.001). BCDVA, CCT and GT were in favor of the DMEK group with a mean value of 0.39 ± 0.35 LogMar, 552.2 ± 71.1 µm and 11.03 ± 1.4 µm, respectively (p < 0.001). Conclusions: CD patterns at the graft–host interface seem to be different depending on the endothelial keratoplasty procedure. This provides specific insight into CD changes in this critical region of surgery, which may provide a better understanding of the postoperative evolution of these patients.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12227133</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Clinical medicine ; Cornea ; Corneal transplantation ; Endothelium ; Eye surgery ; Graft versus host reaction ; Hospitals ; Light ; Patients ; Risk factors ; Surgeons ; Surgical outcomes ; Transplantation ; Variables ; Visual acuity</subject><ispartof>Journal of clinical medicine, 2023-11, Vol.12 (22), p.7133</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-fef0838b0e3866ad0250b74b4cf82fbc30c29225e303ef7feca8bf509200e5673</citedby><cites>FETCH-LOGICAL-c398t-fef0838b0e3866ad0250b74b4cf82fbc30c29225e303ef7feca8bf509200e5673</cites><orcidid>0000-0002-9248-8685 ; 0000-0001-6952-5647 ; 0000-0001-7464-2493 ; 0000-0002-3950-1828 ; 0000-0001-6995-1291 ; 0000-0003-0450-7717</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Ballesteros-Sánchez, Antonio</creatorcontrib><creatorcontrib>Peraza-Nieves, Jorge</creatorcontrib><creatorcontrib>Casablanca-Piñera, Anna</creatorcontrib><creatorcontrib>Rodríguez-Calvo-De-Mora, Marina</creatorcontrib><creatorcontrib>Catalán-Coronado, Saray</creatorcontrib><creatorcontrib>Torras-Sanvicens, Josep</creatorcontrib><creatorcontrib>Borroni, Davide</creatorcontrib><creatorcontrib>Sánchez-González, José-María</creatorcontrib><creatorcontrib>Rocha-De-Lossada, Carlos</creatorcontrib><title>Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study</title><title>Journal of clinical medicine</title><description>Background: To compare corneal densitometry (CD) patterns at the graft–host interface between Descemet Membrane Endothelial Keratoplasty (DMEK) and Descemet Stripping Automated Endothelial Keratoplasty (DSAEK). Corneal densitometry is a quantitative assessment that objectively evaluates corneal clarity and optical quality by measuring the light backscatter from the cornea. Methods: Fifty-one eyes that received DMEK or DSAEK surgery for corneal endothelium dysfunction were evaluated. The primary endpoint included CD patterns at the graft–host interface, which were assessed by the Pentacam HR device at the center point of the corneal horizontal meridian (CDcentral), and at six points on the central circumference of the cornea (with a total diameter of 4 mm) (CDI,II,III,IV,V,VI). Secondary endpoints included the best-corrected distance visual acuity (BCDVA), central corneal thickness (CCT), and graft thickness (GT). All of the evaluations were performed at follow-up appointments one, three, six and twelve months after the procedure. Results: DMEK showed a significant overall CD reduction of −7.9 ± 8.5 grayscale unit (GSU) compared to DSAEK (p < 0.001). In addition, the DMEK group showed significantly lower CDCentral,I,II,III,IV,V,VI values at follow-up appointments one, three, six and twelve months after the procedure compared to the DSAEK group (p < 0.001). BCDVA, CCT and GT were in favor of the DMEK group with a mean value of 0.39 ± 0.35 LogMar, 552.2 ± 71.1 µm and 11.03 ± 1.4 µm, respectively (p < 0.001). Conclusions: CD patterns at the graft–host interface seem to be different depending on the endothelial keratoplasty procedure. This provides specific insight into CD changes in this critical region of surgery, which may provide a better understanding of the postoperative evolution of these patients.</description><subject>Clinical medicine</subject><subject>Cornea</subject><subject>Corneal transplantation</subject><subject>Endothelium</subject><subject>Eye surgery</subject><subject>Graft versus host reaction</subject><subject>Hospitals</subject><subject>Light</subject><subject>Patients</subject><subject>Risk factors</subject><subject>Surgeons</subject><subject>Surgical outcomes</subject><subject>Transplantation</subject><subject>Variables</subject><subject>Visual acuity</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkc1qGzEQx5fSQkOaU19AkEsgrDsr7a60uRnb-SAOLbg9L1p5ZMvsSq6kDfjWQ98gb5gnqYILTUtnDjPM_ObPMJNlHwuYMNbAp50aCkopLxh7k51Q4DwHJtjbV_n77CyEHSQToqQFP8l-rtQWzbDX_bghM-ctyp7M0QYT3YDRH8gXGSN6G4iMJG6R3Hip4_OPp1sXIrmzqaelQmIsmT8s7om0azJfTRf3V2RKCpo_OBu3ZOnsxsRxbWySn7lhL72M5hHJKhUPH7J3WvYBz37H0-zb9eLr7DZffr65m02XuWKNiLlGDYKJDpCJupZroBV0vOxKpQXVnWKgaENphQwYaq5RSdHpChoKgFXN2Wl2cdTde_d9xBDbwQSFfS8tujG0VDTpSFVZNwk9_wfdudGn7Y8U1DXU4g-1kT22xmoXvVQvou2U85JRCiVL1OQ_VPI1DkY5i9qk-l8Dl8cB5V0IHnW792aQ_tAW0L78un31a_YL_rqaZA</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Ballesteros-Sánchez, Antonio</creator><creator>Peraza-Nieves, Jorge</creator><creator>Casablanca-Piñera, Anna</creator><creator>Rodríguez-Calvo-De-Mora, Marina</creator><creator>Catalán-Coronado, Saray</creator><creator>Torras-Sanvicens, Josep</creator><creator>Borroni, Davide</creator><creator>Sánchez-González, José-María</creator><creator>Rocha-De-Lossada, Carlos</creator><general>MDPI AG</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9248-8685</orcidid><orcidid>https://orcid.org/0000-0001-6952-5647</orcidid><orcidid>https://orcid.org/0000-0001-7464-2493</orcidid><orcidid>https://orcid.org/0000-0002-3950-1828</orcidid><orcidid>https://orcid.org/0000-0001-6995-1291</orcidid><orcidid>https://orcid.org/0000-0003-0450-7717</orcidid></search><sort><creationdate>20231101</creationdate><title>Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study</title><author>Ballesteros-Sánchez, Antonio ; Peraza-Nieves, Jorge ; Casablanca-Piñera, Anna ; Rodríguez-Calvo-De-Mora, Marina ; Catalán-Coronado, Saray ; Torras-Sanvicens, Josep ; Borroni, Davide ; Sánchez-González, José-María ; Rocha-De-Lossada, Carlos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-fef0838b0e3866ad0250b74b4cf82fbc30c29225e303ef7feca8bf509200e5673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Clinical medicine</topic><topic>Cornea</topic><topic>Corneal transplantation</topic><topic>Endothelium</topic><topic>Eye surgery</topic><topic>Graft versus host reaction</topic><topic>Hospitals</topic><topic>Light</topic><topic>Patients</topic><topic>Risk factors</topic><topic>Surgeons</topic><topic>Surgical outcomes</topic><topic>Transplantation</topic><topic>Variables</topic><topic>Visual acuity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ballesteros-Sánchez, Antonio</creatorcontrib><creatorcontrib>Peraza-Nieves, Jorge</creatorcontrib><creatorcontrib>Casablanca-Piñera, Anna</creatorcontrib><creatorcontrib>Rodríguez-Calvo-De-Mora, Marina</creatorcontrib><creatorcontrib>Catalán-Coronado, Saray</creatorcontrib><creatorcontrib>Torras-Sanvicens, Josep</creatorcontrib><creatorcontrib>Borroni, Davide</creatorcontrib><creatorcontrib>Sánchez-González, José-María</creatorcontrib><creatorcontrib>Rocha-De-Lossada, Carlos</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ballesteros-Sánchez, Antonio</au><au>Peraza-Nieves, Jorge</au><au>Casablanca-Piñera, Anna</au><au>Rodríguez-Calvo-De-Mora, Marina</au><au>Catalán-Coronado, Saray</au><au>Torras-Sanvicens, Josep</au><au>Borroni, Davide</au><au>Sánchez-González, José-María</au><au>Rocha-De-Lossada, Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study</atitle><jtitle>Journal of clinical medicine</jtitle><date>2023-11-01</date><risdate>2023</risdate><volume>12</volume><issue>22</issue><spage>7133</spage><pages>7133-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Background: To compare corneal densitometry (CD) patterns at the graft–host interface between Descemet Membrane Endothelial Keratoplasty (DMEK) and Descemet Stripping Automated Endothelial Keratoplasty (DSAEK). Corneal densitometry is a quantitative assessment that objectively evaluates corneal clarity and optical quality by measuring the light backscatter from the cornea. Methods: Fifty-one eyes that received DMEK or DSAEK surgery for corneal endothelium dysfunction were evaluated. The primary endpoint included CD patterns at the graft–host interface, which were assessed by the Pentacam HR device at the center point of the corneal horizontal meridian (CDcentral), and at six points on the central circumference of the cornea (with a total diameter of 4 mm) (CDI,II,III,IV,V,VI). Secondary endpoints included the best-corrected distance visual acuity (BCDVA), central corneal thickness (CCT), and graft thickness (GT). All of the evaluations were performed at follow-up appointments one, three, six and twelve months after the procedure. Results: DMEK showed a significant overall CD reduction of −7.9 ± 8.5 grayscale unit (GSU) compared to DSAEK (p < 0.001). In addition, the DMEK group showed significantly lower CDCentral,I,II,III,IV,V,VI values at follow-up appointments one, three, six and twelve months after the procedure compared to the DSAEK group (p < 0.001). BCDVA, CCT and GT were in favor of the DMEK group with a mean value of 0.39 ± 0.35 LogMar, 552.2 ± 71.1 µm and 11.03 ± 1.4 µm, respectively (p < 0.001). Conclusions: CD patterns at the graft–host interface seem to be different depending on the endothelial keratoplasty procedure. This provides specific insight into CD changes in this critical region of surgery, which may provide a better understanding of the postoperative evolution of these patients.</abstract><cop>Basel</cop><pub>MDPI AG</pub><doi>10.3390/jcm12227133</doi><orcidid>https://orcid.org/0000-0002-9248-8685</orcidid><orcidid>https://orcid.org/0000-0001-6952-5647</orcidid><orcidid>https://orcid.org/0000-0001-7464-2493</orcidid><orcidid>https://orcid.org/0000-0002-3950-1828</orcidid><orcidid>https://orcid.org/0000-0001-6995-1291</orcidid><orcidid>https://orcid.org/0000-0003-0450-7717</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Clinical medicine Cornea Corneal transplantation Endothelium Eye surgery Graft versus host reaction Hospitals Light Patients Risk factors Surgeons Surgical outcomes Transplantation Variables Visual acuity |
title | Scheimpflug Corneal Densitometry Patterns at the Graft–Host Interface in DMEK and DSAEK: A 12-Month Longitudinal Comparative Study |
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