Systemic lupus erythematosus is associated with lower risk of hepatitis B virus infection: A multivariable Mendelian randomization study in East Asian population
The relationship between systemic lupus erythematosus (SLE) and hepatitis B virus (HBV) infection is still unclear. We conducted a two‐sample Mendelian randomization (MR) analysis using summary statistics from genome‐wide association studies for SLE and HBV infection in individuals of East Asian anc...
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| Veröffentlicht in: | Journal of medical virology 2023-11, Vol.95 (11), p.e29226-n/a |
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| creator | Li, Wei Zhang, Hua Ren, Ao Fan, Wei Qin, Qiong Zhao, Ling Ma, Ruidong Peng, Qiufeng Luo, Shiqiao |
| description | The relationship between systemic lupus erythematosus (SLE) and hepatitis B virus (HBV) infection is still unclear. We conducted a two‐sample Mendelian randomization (MR) analysis using summary statistics from genome‐wide association studies for SLE and HBV infection in individuals of East Asian ancestry. The inverse‐variance weighted (IVW) method, weighted median (WM) method, and MR‐Egger method were used to estimate the causal effect of SLE on HBV infection. Additionally, we performed a multivariable MR analysis adjusting for the effects of body mass index and rheumatoid arthritis. This MR study included a total of 225 106 individuals of East Asian ancestry, comprising 5616 cases and 219 490 controls. The IVW method (OR: 0.79, p = 3.34E−08) and the WM method (OR: 0.79, p = 9.09E−06) revealed a causal relationship between genetically predicted SLE and a low risk of HBV infection. The multivariable MR analysis still suggested a low risk of HBV infection associated with SLE (OR: 0.83, p = 2.89E−06). Our MR analysis supports a causal relationship between SLE and a low risk of HBV infection in individuals of East Asian ancestry. |
| doi_str_mv | 10.1002/jmv.29226 |
| format | Article |
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We conducted a two‐sample Mendelian randomization (MR) analysis using summary statistics from genome‐wide association studies for SLE and HBV infection in individuals of East Asian ancestry. The inverse‐variance weighted (IVW) method, weighted median (WM) method, and MR‐Egger method were used to estimate the causal effect of SLE on HBV infection. Additionally, we performed a multivariable MR analysis adjusting for the effects of body mass index and rheumatoid arthritis. This MR study included a total of 225 106 individuals of East Asian ancestry, comprising 5616 cases and 219 490 controls. The IVW method (OR: 0.79, p = 3.34E−08) and the WM method (OR: 0.79, p = 9.09E−06) revealed a causal relationship between genetically predicted SLE and a low risk of HBV infection. The multivariable MR analysis still suggested a low risk of HBV infection associated with SLE (OR: 0.83, p = 2.89E−06). Our MR analysis supports a causal relationship between SLE and a low risk of HBV infection in individuals of East Asian ancestry.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.29226</identifier><identifier>PMID: 37997467</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Autoimmune diseases ; Body mass ; Body mass index ; Body size ; causal relationship ; Chronic conditions ; East Asian People ; Genome-Wide Association Study ; Genomes ; GWAS ; HBV ; Health risks ; Hepatitis ; Hepatitis B ; Hepatitis B - complications ; Hepatitis B - epidemiology ; Hepatitis B - genetics ; Hepatitis B virus - genetics ; Humans ; Infections ; Lupus ; Lupus Erythematosus, Systemic - complications ; Lupus Erythematosus, Systemic - epidemiology ; Lupus Erythematosus, Systemic - genetics ; Mendelian randomization ; Mendelian Randomization Analysis ; Polymorphism, Single Nucleotide ; Population studies ; Randomization ; Rheumatoid arthritis ; Risk ; SLE ; Statistical analysis ; Systemic lupus erythematosus ; Virology ; Viruses</subject><ispartof>Journal of medical virology, 2023-11, Vol.95 (11), p.e29226-n/a</ispartof><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3136-7897e8f28dcdd5f9c21f1057899ec4f61f15948bf0fa7e15fdb7ed6e72de61073</cites><orcidid>0000-0002-4536-8592</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.29226$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.29226$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37997467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Zhang, Hua</creatorcontrib><creatorcontrib>Ren, Ao</creatorcontrib><creatorcontrib>Fan, Wei</creatorcontrib><creatorcontrib>Qin, Qiong</creatorcontrib><creatorcontrib>Zhao, Ling</creatorcontrib><creatorcontrib>Ma, Ruidong</creatorcontrib><creatorcontrib>Peng, Qiufeng</creatorcontrib><creatorcontrib>Luo, Shiqiao</creatorcontrib><title>Systemic lupus erythematosus is associated with lower risk of hepatitis B virus infection: A multivariable Mendelian randomization study in East Asian population</title><title>Journal of medical virology</title><addtitle>J Med Virol</addtitle><description>The relationship between systemic lupus erythematosus (SLE) and hepatitis B virus (HBV) infection is still unclear. We conducted a two‐sample Mendelian randomization (MR) analysis using summary statistics from genome‐wide association studies for SLE and HBV infection in individuals of East Asian ancestry. The inverse‐variance weighted (IVW) method, weighted median (WM) method, and MR‐Egger method were used to estimate the causal effect of SLE on HBV infection. Additionally, we performed a multivariable MR analysis adjusting for the effects of body mass index and rheumatoid arthritis. This MR study included a total of 225 106 individuals of East Asian ancestry, comprising 5616 cases and 219 490 controls. The IVW method (OR: 0.79, p = 3.34E−08) and the WM method (OR: 0.79, p = 9.09E−06) revealed a causal relationship between genetically predicted SLE and a low risk of HBV infection. The multivariable MR analysis still suggested a low risk of HBV infection associated with SLE (OR: 0.83, p = 2.89E−06). Our MR analysis supports a causal relationship between SLE and a low risk of HBV infection in individuals of East Asian ancestry.</description><subject>Autoimmune diseases</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>causal relationship</subject><subject>Chronic conditions</subject><subject>East Asian People</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>GWAS</subject><subject>HBV</subject><subject>Health risks</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B - complications</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - genetics</subject><subject>Hepatitis B virus - genetics</subject><subject>Humans</subject><subject>Infections</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic - complications</subject><subject>Lupus Erythematosus, Systemic - epidemiology</subject><subject>Lupus Erythematosus, Systemic - genetics</subject><subject>Mendelian randomization</subject><subject>Mendelian Randomization Analysis</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population studies</subject><subject>Randomization</subject><subject>Rheumatoid arthritis</subject><subject>Risk</subject><subject>SLE</subject><subject>Statistical analysis</subject><subject>Systemic lupus erythematosus</subject><subject>Virology</subject><subject>Viruses</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10ctu1DAUBmALgehQWPACyBIbWKS1ncSO2Q1Vy0WtWHDZRp74WOPBiVPbmVH6NrwpTqewQGJlHfs7vyz9CL2k5IwSws53_f6MScb4I7SiRPJCEkEfoxWhFS84p_UJehbjjhDSZPUUnZRCSlFxsUK_vs4xQW877KZxihjCnLbQq-RjnmzEKkbfWZVA44NNW-z8AQIONv7E3uAtjCrZlN17vLdhWRkMdMn64R1e435yye5VsGrjAN_AoMFZNeCgBu17e6cWiGOa9JwX8aWKCa_jIkY_Tu7--Tl6YpSL8OLhPEXfry6_XXwsrr98-HSxvi66kpa8EI0U0BjW6E7r2siOUUNJna8ldJXheapl1WwMMUoArY3eCNAcBNPAKRHlKXpzzB2Dv50gpra3sQPn1AB-ii1rZNmUlaQs09f_0J2fwpB_t6iqrGnV1Fm9Paou-BgDmHYMtldhbilpl97a3Ft731u2rx4Sp00P-q_8U1QG50dwsA7m_ye1n29-HCN_A2cipek</recordid><startdate>202311</startdate><enddate>202311</enddate><creator>Li, Wei</creator><creator>Zhang, Hua</creator><creator>Ren, Ao</creator><creator>Fan, Wei</creator><creator>Qin, Qiong</creator><creator>Zhao, Ling</creator><creator>Ma, Ruidong</creator><creator>Peng, Qiufeng</creator><creator>Luo, Shiqiao</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4536-8592</orcidid></search><sort><creationdate>202311</creationdate><title>Systemic lupus erythematosus is associated with lower risk of hepatitis B virus infection: A multivariable Mendelian randomization study in East Asian population</title><author>Li, Wei ; Zhang, Hua ; Ren, Ao ; Fan, Wei ; Qin, Qiong ; Zhao, Ling ; Ma, Ruidong ; Peng, Qiufeng ; Luo, Shiqiao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3136-7897e8f28dcdd5f9c21f1057899ec4f61f15948bf0fa7e15fdb7ed6e72de61073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Autoimmune diseases</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>causal relationship</topic><topic>Chronic conditions</topic><topic>East Asian People</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>GWAS</topic><topic>HBV</topic><topic>Health risks</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B - complications</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B - genetics</topic><topic>Hepatitis B virus - genetics</topic><topic>Humans</topic><topic>Infections</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic - complications</topic><topic>Lupus Erythematosus, Systemic - epidemiology</topic><topic>Lupus Erythematosus, Systemic - genetics</topic><topic>Mendelian randomization</topic><topic>Mendelian Randomization Analysis</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Population studies</topic><topic>Randomization</topic><topic>Rheumatoid arthritis</topic><topic>Risk</topic><topic>SLE</topic><topic>Statistical analysis</topic><topic>Systemic lupus erythematosus</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Zhang, Hua</creatorcontrib><creatorcontrib>Ren, Ao</creatorcontrib><creatorcontrib>Fan, Wei</creatorcontrib><creatorcontrib>Qin, Qiong</creatorcontrib><creatorcontrib>Zhao, Ling</creatorcontrib><creatorcontrib>Ma, Ruidong</creatorcontrib><creatorcontrib>Peng, Qiufeng</creatorcontrib><creatorcontrib>Luo, Shiqiao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Wei</au><au>Zhang, Hua</au><au>Ren, Ao</au><au>Fan, Wei</au><au>Qin, Qiong</au><au>Zhao, Ling</au><au>Ma, Ruidong</au><au>Peng, Qiufeng</au><au>Luo, Shiqiao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic lupus erythematosus is associated with lower risk of hepatitis B virus infection: A multivariable Mendelian randomization study in East Asian population</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J Med Virol</addtitle><date>2023-11</date><risdate>2023</risdate><volume>95</volume><issue>11</issue><spage>e29226</spage><epage>n/a</epage><pages>e29226-n/a</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>The relationship between systemic lupus erythematosus (SLE) and hepatitis B virus (HBV) infection is still unclear. We conducted a two‐sample Mendelian randomization (MR) analysis using summary statistics from genome‐wide association studies for SLE and HBV infection in individuals of East Asian ancestry. The inverse‐variance weighted (IVW) method, weighted median (WM) method, and MR‐Egger method were used to estimate the causal effect of SLE on HBV infection. Additionally, we performed a multivariable MR analysis adjusting for the effects of body mass index and rheumatoid arthritis. This MR study included a total of 225 106 individuals of East Asian ancestry, comprising 5616 cases and 219 490 controls. The IVW method (OR: 0.79, p = 3.34E−08) and the WM method (OR: 0.79, p = 9.09E−06) revealed a causal relationship between genetically predicted SLE and a low risk of HBV infection. The multivariable MR analysis still suggested a low risk of HBV infection associated with SLE (OR: 0.83, p = 2.89E−06). Our MR analysis supports a causal relationship between SLE and a low risk of HBV infection in individuals of East Asian ancestry.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37997467</pmid><doi>10.1002/jmv.29226</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-4536-8592</orcidid></addata></record> |
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| subjects | Autoimmune diseases Body mass Body mass index Body size causal relationship Chronic conditions East Asian People Genome-Wide Association Study Genomes GWAS HBV Health risks Hepatitis Hepatitis B Hepatitis B - complications Hepatitis B - epidemiology Hepatitis B - genetics Hepatitis B virus - genetics Humans Infections Lupus Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - epidemiology Lupus Erythematosus, Systemic - genetics Mendelian randomization Mendelian Randomization Analysis Polymorphism, Single Nucleotide Population studies Randomization Rheumatoid arthritis Risk SLE Statistical analysis Systemic lupus erythematosus Virology Viruses |
| title | Systemic lupus erythematosus is associated with lower risk of hepatitis B virus infection: A multivariable Mendelian randomization study in East Asian population |
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