ASIC1a contributes to the epithelial–mesenchymal transformation of breast cancer by activating the Ca2+/β‐catenin pathway

Breast cancer is the most common cancer in the world, with metastasis being one of the leading causes of death among patients. The acidic environment of breast cancer tissue promotes tumor cell invasion and migration by inducing epithelial–mesenchymal transformation (EMT) in tumor cells, but the exa...

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Veröffentlicht in:	Environmental toxicology 2024-02, Vol.39 (2), p.991-1000
Hauptverfasser:	Wang, Jiawei, Yang, Chao, Yu, Ruihua, Zhuang, Ming, Jiang, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	acid‐sensitive ion channel 1a (ASIC1a) Biomarkers Breast cancer Ca2 Calcium (intracellular) Calcium influx Calcium ions Cancer Cancer therapies Catenin Cell activation Cell migration epithelial–mesenchymal transformation (EMT) In vivo methods and tests Ion channels Lymph Lymph nodes Metastases Metastasis Microenvironments Neoplasms Tissue Tumor cells Tumors Vimentin β‐Catenin
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