Evaluation of the acute toxicity of ellagic acid and gallic acid incorporated in Poloxamer407® gel, in Zophobas morio larvae

Evaluation of the acute toxicity of ellagic acid and gallic acid incorporated in Poloxamer407® gel, in Zophobas morio larvae

Gallic acid (GA) has antioxidant, anti-inflammatory and antimicrobial properties, while ellagic acid (EA) demonstrates anticancer, antiviral and photoprotective activity. In this study, the combination of these substances incorporated into a poloxamer gel was tested to verify the individual effect o...

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Veröffentlicht in:Toxicology in vitro 2024-03, Vol.95, p.105727-105727, Article 105727
Hauptverfasser: Campelo, Jamilly Erica Sousa, Nascimento, Matheus Oliveira do, Carvalho, André Luis Menezes, Santos, Hayana Sara Pereira, Almeida, José Otavio Carvalho Sena de, Alves, Michel Mualem de Moraes, Arcanjo, Daniel Dias Rufino, Tavares Neto, José Moreira, Muratori, Maria Christina Sanches, Costa, Amilton Paulo Raposo
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Sprache:eng
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Zusammenfassung:Gallic acid (GA) has antioxidant, anti-inflammatory and antimicrobial properties, while ellagic acid (EA) demonstrates anticancer, antiviral and photoprotective activity. In this study, the combination of these substances incorporated into a poloxamer gel was tested to verify the individual effect of the substances, in addition to taking advantage of a probable complementary effect, aiming to provide additional therapeutic benefits. As a result of the incorporation, formulations containing GA, EA and GA + EA were obtained, which were evaluated for the effects of the Freeze-thaw cycle on pH, which revealed a significant decrease (p 
ISSN:0887-2333
1879-3177
DOI:10.1016/j.tiv.2023.105727