Biosynthesis of trans-AT PKS-Derived Shuangdaolides Featuring a trans-acting Enzyme for Online Epoxidation

Bacterial trans-acyltransferase polyketide synthases (trans-AT PKSs) synthesize natural products with intricate structures and potent biological activities. They generally contain various unusual modules or trans-acting enzymes. Herein, we report the trans-AT PKS-derived biosynthetic pathway of the...

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Veröffentlicht in:	ACS chemical biology 2023-12, Vol.18 (12), p.2474-2484
Hauptverfasser:	Liu, Yang, Zhou, Haibo, Zhao, Shuang, Hao, Xingkun, Dai, Guangzhi, Zhong, Lin, Ren, Xiangmei, Sui, Haiyan, Zhang, Youming, Yan, Fu, Bian, Xiaoying
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - metabolism Biological Products Epoxy Compounds Polyketide Synthases - metabolism Polyketides - chemistry
Online-Zugang:	Volltext
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