Discovery of Anti-SARS-CoV‑2 Nsp9 Binders from Natural Products by a Native Mass Spectrometry Approach

The search for effective antiviral agents against SARS-CoV-2 remains a critical global endeavor. In this study, we focused on the viral nucleocapsid protein Nsp9, which is a key player in viral RNA replication and an attractive drug target. Employing a two-pronged approach, an in-house natural produ...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2023-12, Vol.86 (12), p.2630-2637
Hauptverfasser:	Quinn, Ronald J., Mak, Tin, Littler, Dene R., Rossjohn, Jamie, Liu, Miaomiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - pharmacology COVID-19 Diterpenes, Kaurane - pharmacology Humans Protein Binding SARS-CoV-2
Online-Zugang:	Volltext
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