Trends in Cardiovascular Mortality Among Patients With Alzheimer's Disease in the United States from 1999 to 2020
This study aimed to compare the trends in cardiovascular diseases (CVDs)-related mortality in patients with Alzheimer's disease (AD) and in the general population aged ≥65 years. Data from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research Multipl...
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| Veröffentlicht in: | The American journal of cardiology 2024-01, Vol.211, p.326-333 |
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| container_title | The American journal of cardiology |
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| creator | Ranganathan, Sruthi Abramov, Dmitry Chew, Nicholas W S Mallen, Christian Marshall, Michelle Kobo, Ofer Mamas, Mamas A |
| description | This study aimed to compare the trends in cardiovascular diseases (CVDs)-related mortality in patients with Alzheimer's disease (AD) and in the general population aged ≥65 years. Data from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research Multiple Cause of Death dataset were used to determine national trends in age-adjusted CVD mortality rates (AAMR) and average annual percent change (AAPC) values in patients with AD and the overall population aged ≥65 years from 1999 to 2020. Data for AAMR and AAPCs were also stratified by age, gender, ethnicity/race, geographical region, urbanization status, and subgroups of CVD. Trends in the overall AAMR stratified by gender, age, ethnicity/race, geographical region, urbanization status, and CVD subgroups were statistically different between patients with AD and the overall population (overall AAPC for CVD mortality rate in patients with AD = -3.5% [confidence interval -4.1% to -2.9%] vs -2.6% [confidence interval -2.3% to -2.9%] in overall population, p = 0.01). Differences in the decrease in the mortality rates between patients with AD and the overall population were found to be statistically different across all stratifications except for the change in the mortality rates for hypertensive diseases (p = 0.05), females (p = 0.2), and Asian or Pacific Islanders (p = 0.09). In conclusion, CVD-related mortality in patients with AD decreased over the last 2 decades, and decreases were more prominent than seen in the general population aged ≥65 years. These results may help focus public health efforts to optimize CVD health in patients with AD. |
| doi_str_mv | 10.1016/j.amjcard.2023.11.044 |
| format | Article |
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Data from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research Multiple Cause of Death dataset were used to determine national trends in age-adjusted CVD mortality rates (AAMR) and average annual percent change (AAPC) values in patients with AD and the overall population aged ≥65 years from 1999 to 2020. Data for AAMR and AAPCs were also stratified by age, gender, ethnicity/race, geographical region, urbanization status, and subgroups of CVD. Trends in the overall AAMR stratified by gender, age, ethnicity/race, geographical region, urbanization status, and CVD subgroups were statistically different between patients with AD and the overall population (overall AAPC for CVD mortality rate in patients with AD = -3.5% [confidence interval -4.1% to -2.9%] vs -2.6% [confidence interval -2.3% to -2.9%] in overall population, p = 0.01). Differences in the decrease in the mortality rates between patients with AD and the overall population were found to be statistically different across all stratifications except for the change in the mortality rates for hypertensive diseases (p = 0.05), females (p = 0.2), and Asian or Pacific Islanders (p = 0.09). In conclusion, CVD-related mortality in patients with AD decreased over the last 2 decades, and decreases were more prominent than seen in the general population aged ≥65 years. These results may help focus public health efforts to optimize CVD health in patients with AD.</description><identifier>ISSN: 0002-9149</identifier><identifier>ISSN: 1879-1913</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2023.11.044</identifier><identifier>PMID: 37993040</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Age ; Alzheimer's disease ; Apolipoproteins ; Cardiovascular diseases ; Dementia ; Disease control ; Epidemiology ; Ethnicity ; Gender ; Health risk assessment ; Hypertension ; Minority & ethnic groups ; Mortality ; Neurodegenerative diseases ; Pathogenesis ; Patients ; Population (statistical) ; Public health ; Race ; Risk factors ; Software ; Subgroups ; Trends ; Urbanization ; Womens health</subject><ispartof>The American journal of cardiology, 2024-01, Vol.211, p.326-333</ispartof><rights>Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.</rights><rights>2023. The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-ae557cdc01aa08181425d1bf10971e89300b844e21598481708ef7d8f75a86df3</citedby><cites>FETCH-LOGICAL-c337t-ae557cdc01aa08181425d1bf10971e89300b844e21598481708ef7d8f75a86df3</cites><orcidid>0009-0003-0684-4263</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2909638640?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37993040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ranganathan, Sruthi</creatorcontrib><creatorcontrib>Abramov, Dmitry</creatorcontrib><creatorcontrib>Chew, Nicholas W S</creatorcontrib><creatorcontrib>Mallen, Christian</creatorcontrib><creatorcontrib>Marshall, Michelle</creatorcontrib><creatorcontrib>Kobo, Ofer</creatorcontrib><creatorcontrib>Mamas, Mamas A</creatorcontrib><title>Trends in Cardiovascular Mortality Among Patients With Alzheimer's Disease in the United States from 1999 to 2020</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>This study aimed to compare the trends in cardiovascular diseases (CVDs)-related mortality in patients with Alzheimer's disease (AD) and in the general population aged ≥65 years. Data from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research Multiple Cause of Death dataset were used to determine national trends in age-adjusted CVD mortality rates (AAMR) and average annual percent change (AAPC) values in patients with AD and the overall population aged ≥65 years from 1999 to 2020. Data for AAMR and AAPCs were also stratified by age, gender, ethnicity/race, geographical region, urbanization status, and subgroups of CVD. Trends in the overall AAMR stratified by gender, age, ethnicity/race, geographical region, urbanization status, and CVD subgroups were statistically different between patients with AD and the overall population (overall AAPC for CVD mortality rate in patients with AD = -3.5% [confidence interval -4.1% to -2.9%] vs -2.6% [confidence interval -2.3% to -2.9%] in overall population, p = 0.01). Differences in the decrease in the mortality rates between patients with AD and the overall population were found to be statistically different across all stratifications except for the change in the mortality rates for hypertensive diseases (p = 0.05), females (p = 0.2), and Asian or Pacific Islanders (p = 0.09). In conclusion, CVD-related mortality in patients with AD decreased over the last 2 decades, and decreases were more prominent than seen in the general population aged ≥65 years. These results may help focus public health efforts to optimize CVD health in patients with AD.</description><subject>Age</subject><subject>Alzheimer's disease</subject><subject>Apolipoproteins</subject><subject>Cardiovascular diseases</subject><subject>Dementia</subject><subject>Disease control</subject><subject>Epidemiology</subject><subject>Ethnicity</subject><subject>Gender</subject><subject>Health risk assessment</subject><subject>Hypertension</subject><subject>Minority & ethnic groups</subject><subject>Mortality</subject><subject>Neurodegenerative diseases</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Population (statistical)</subject><subject>Public health</subject><subject>Race</subject><subject>Risk factors</subject><subject>Software</subject><subject>Subgroups</subject><subject>Trends</subject><subject>Urbanization</subject><subject>Womens health</subject><issn>0002-9149</issn><issn>1879-1913</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkVGL1DAUhYMo7uzqT1ACPuhL671N2iaPw6yuwoqCu_gYMu2tk9I2u0kqrL_eDDv64NPlwncOBz7GXiGUCNi8H0s7j50NfVlBJUrEEqR8wjaoWl2gRvGUbQCgKjRKfcbOYxzzi1g3z9mZaLUWIGHD7m8CLX3kbuG7XOb8Lxu7dbKBf_Eh2cmlB76d_fKTf7PJ0ZIi_-HSgW-n3wdyM4W3kV-6SDbSsSMdiN8uLlHPvyebKPIh-Jmj1ponz_NUeMGeDXaK9PJ0L9jtxw83u0_F9derz7vtddEJ0abCUl23Xd8BWgsKFcqq7nE_IOgWSeX5sFdSUoW1VlJhC4qGtldDW1vV9IO4YO8ee--Cv18pJjO72NE02YX8Gk2ldKVl0wqV0Tf_oaNfw5LXmUqDboRqJGSqfqS64GMMNJi74GYbHgyCOToxozk5MUcnBtFkJzn3-tS-7mfq_6X-ShB_AP86h5Q</recordid><startdate>20240115</startdate><enddate>20240115</enddate><creator>Ranganathan, Sruthi</creator><creator>Abramov, Dmitry</creator><creator>Chew, Nicholas W S</creator><creator>Mallen, Christian</creator><creator>Marshall, Michelle</creator><creator>Kobo, Ofer</creator><creator>Mamas, Mamas A</creator><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0003-0684-4263</orcidid></search><sort><creationdate>20240115</creationdate><title>Trends in Cardiovascular Mortality Among Patients With Alzheimer's Disease in the United States from 1999 to 2020</title><author>Ranganathan, Sruthi ; 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Data from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research Multiple Cause of Death dataset were used to determine national trends in age-adjusted CVD mortality rates (AAMR) and average annual percent change (AAPC) values in patients with AD and the overall population aged ≥65 years from 1999 to 2020. Data for AAMR and AAPCs were also stratified by age, gender, ethnicity/race, geographical region, urbanization status, and subgroups of CVD. Trends in the overall AAMR stratified by gender, age, ethnicity/race, geographical region, urbanization status, and CVD subgroups were statistically different between patients with AD and the overall population (overall AAPC for CVD mortality rate in patients with AD = -3.5% [confidence interval -4.1% to -2.9%] vs -2.6% [confidence interval -2.3% to -2.9%] in overall population, p = 0.01). Differences in the decrease in the mortality rates between patients with AD and the overall population were found to be statistically different across all stratifications except for the change in the mortality rates for hypertensive diseases (p = 0.05), females (p = 0.2), and Asian or Pacific Islanders (p = 0.09). In conclusion, CVD-related mortality in patients with AD decreased over the last 2 decades, and decreases were more prominent than seen in the general population aged ≥65 years. These results may help focus public health efforts to optimize CVD health in patients with AD.</abstract><cop>United States</cop><pub>Elsevier Limited</pub><pmid>37993040</pmid><doi>10.1016/j.amjcard.2023.11.044</doi><tpages>8</tpages><orcidid>https://orcid.org/0009-0003-0684-4263</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Alzheimer's disease Apolipoproteins Cardiovascular diseases Dementia Disease control Epidemiology Ethnicity Gender Health risk assessment Hypertension Minority & ethnic groups Mortality Neurodegenerative diseases Pathogenesis Patients Population (statistical) Public health Race Risk factors Software Subgroups Trends Urbanization Womens health |
| title | Trends in Cardiovascular Mortality Among Patients With Alzheimer's Disease in the United States from 1999 to 2020 |
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