Recombinant human HspB5-ACD structural domain inhibits neurotoxicity by regulating pathological α-Syn aggregation

The treatment of Parkinson's disease is a global medical challenge. α-Synuclein (α-Syn) is the causative protein in Parkinson's disease and is closely linked to its progression. Therefore, inhibiting the pathological aggregation of α-Syn and its neurotoxicity is essential for the treatment...

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Veröffentlicht in:	International journal of biological macromolecules 2024-01, Vol.255, p.128311-128311, Article 128311
Hauptverfasser:	Liu, Chang, Ding, Xuying, Guo, Xiao, Zhao, Meijun, Zhang, Xiaojun, Li, Ziqing, Zhao, Risheng, Cao, Yuyan, Xing, Jiaying
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - chemistry Animals Apoptosis Dopaminergic Neurons Escherichia coli - metabolism Humans Parkinson Disease - metabolism Protein Aggregation, Pathological - metabolism
Online-Zugang:	Volltext
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