Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase HECTD1, promotes esophageal squamous cell carcinoma progression

Nucleoporin 93 (NUP93) is an important component of the nuclear pore complex, exhibiting pro-tumorigenic properties in some cancers. However, its function in esophageal squamous cell carcinoma (ESCC) has not been elucidated. This study aimed to investigate the effects of NUP93 in ESCC and the underl...

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Veröffentlicht in:	Human cell : official journal of Human Cell Research Society 2024-01, Vol.37 (1), p.245-257
Hauptverfasser:	Zhang, Jinfeng, Xin, Yanzhong, Ling, Xiaodong, Liang, Hao, Zhang, Luquan, Fang, Chengyuan, Ma, Jianqun
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animals Apoptosis B7-H1 Antigen - metabolism Biomedical and Life Sciences Cell Biology Cell cycle Cell Line, Tumor Cell migration Cell Movement - genetics Cell proliferation Cell Proliferation - genetics Epithelial-Mesenchymal Transition Esophageal cancer Esophageal carcinoma Esophageal Neoplasms - pathology Esophageal Squamous Cell Carcinoma - genetics Esophageal Squamous Cell Carcinoma - pathology Esophagus Gene Expression Regulation, Neoplastic Gynecology Humans Life Sciences Lysis Mice Mice, Nude Natural killer cells Nuclear Pore Complex Proteins - genetics Nuclear Pore Complex Proteins - metabolism Nuclear pores Oncology PD-L1 protein Proto-Oncogene Proteins c-akt - metabolism Puromycin Reproductive Medicine Research Article Signal transduction Squamous cell carcinoma Stem Cells Surgery Therapeutic targets Tumor suppressor genes Tumors Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
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