Tetrahydropalmatine: Orchestrating survival – Regulating autophagy and apoptosis via the PI3K/AKT/mTOR pathway in perforator flaps

Introduced in clinical practice in 1989, perforator flaps are vital for tissue defect repair, but they are challenged by distal necrosis. Tetrahydropalmatine (THP) from celandine is renowned for its anti-inflammatory and analgesic effects. This study investigates THP's use in perforator flaps....

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2023-12, Vol.169, p.115887-115887, Article 115887
Hauptverfasser:	Chen, Xuankuai, Fu, Kejian, Lai, Yingying, Dong, Chengji, Chen, Zhuliu, Huang, Yingying, Li, Guangyao, Jiang, Renhao, Wu, Hongqiang, Wang, Anyuan, Huang, Shaojie, Shen, Liyan, Gao, Weiyang, Li, Shi
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Apoptosis Autophagy Multi-territory perforator flap Oxidative stress Tetrahydropalmatine
Online-Zugang:	Volltext
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