International council for standardisation in haematology recommendations on fibrinogen assays, thrombin clotting time and related tests in the investigation of bleeding disorders
This guidance was prepared on behalf of the International Council for Standardisation in Haematology (ICSH) by an international working group of clinicians and scientists. The document focuses on tests and assays used for the assessment of fibrinogen function, particularly in the scenario of bleedin...
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Veröffentlicht in: | International journal of laboratory hematology 2024-02, Vol.46 (1), p.20-32 |
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description | This guidance was prepared on behalf of the International Council for Standardisation in Haematology (ICSH) by an international working group of clinicians and scientists. The document focuses on tests and assays used for the assessment of fibrinogen function, particularly in the scenario of bleeding disorders. Thrombin clotting time (TT) is used as a screening test in some laboratories and also has some utility when direct anticoagulants are in use. The Clauss fibrinogen assay remains the method of choice for the assessment of fibrinogen function, but there are some situations where the results may be misleading. Prothrombin time derived fibrinogen assays are frequently used, but should be interpreted with caution; the results are not interchangeable between different methods and fibrinogen can be overestimated in certain clinical scenarios. Viscoelastic point of care methods may be helpful in emergency situations, while Reptilase time (and similar tests) are useful combined with TT in distinguishing heparin contamination of samples (i.e., if an incorrect blood draw is suspected) and the presence of direct thrombin inhibitors. Fibrinogen antigen assays should be used in the investigation of functional fibrinogen abnormalities; fibrinogen antigen and genetic testing are recommended in the confirmation of congenital fibrinogen disorders. The following recommendations for fibrinogen function assessment are based on published literature and expert opinion and should supplement local regulations and standards. |
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The document focuses on tests and assays used for the assessment of fibrinogen function, particularly in the scenario of bleeding disorders. Thrombin clotting time (TT) is used as a screening test in some laboratories and also has some utility when direct anticoagulants are in use. The Clauss fibrinogen assay remains the method of choice for the assessment of fibrinogen function, but there are some situations where the results may be misleading. Prothrombin time derived fibrinogen assays are frequently used, but should be interpreted with caution; the results are not interchangeable between different methods and fibrinogen can be overestimated in certain clinical scenarios. Viscoelastic point of care methods may be helpful in emergency situations, while Reptilase time (and similar tests) are useful combined with TT in distinguishing heparin contamination of samples (i.e., if an incorrect blood draw is suspected) and the presence of direct thrombin inhibitors. Fibrinogen antigen assays should be used in the investigation of functional fibrinogen abnormalities; fibrinogen antigen and genetic testing are recommended in the confirmation of congenital fibrinogen disorders. The following recommendations for fibrinogen function assessment are based on published literature and expert opinion and should supplement local regulations and standards.</description><identifier>ISSN: 1751-5521</identifier><identifier>EISSN: 1751-553X</identifier><identifier>DOI: 10.1111/ijlh.14201</identifier><identifier>PMID: 37984807</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Anticoagulants ; Antigens ; Bleeding ; Blood Coagulation Disorders ; Blood Coagulation Tests - methods ; Clotting ; Contamination ; Fibrinogen ; Fibrinogen - analysis ; fibrinogen assay ; Genetic screening ; Hematology ; Hemophilia ; Hemostatics ; Heparin ; Humans ; Prothrombin ; Thrombin ; Thrombin Time ; Viscoelasticity</subject><ispartof>International journal of laboratory hematology, 2024-02, Vol.46 (1), p.20-32</ispartof><rights>2023 John Wiley & Sons Ltd.</rights><rights>2024 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3931-db9475be68e380947c7494c9dac5c726d7f1528e047b8bd4bf07dbb123ab94eb3</citedby><cites>FETCH-LOGICAL-c3931-db9475be68e380947c7494c9dac5c726d7f1528e047b8bd4bf07dbb123ab94eb3</cites><orcidid>0000-0002-7194-3183 ; 0000-0002-7393-2365 ; 0000-0002-6969-929X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijlh.14201$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijlh.14201$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37984807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mackie, Ian</creatorcontrib><creatorcontrib>Casini, Alessandro</creatorcontrib><creatorcontrib>Pieters, Marlien</creatorcontrib><creatorcontrib>Pruthi, Rajiv</creatorcontrib><creatorcontrib>Reilly‐Stitt, Chris</creatorcontrib><creatorcontrib>Suzuki, Atsuo</creatorcontrib><title>International council for standardisation in haematology recommendations on fibrinogen assays, thrombin clotting time and related tests in the investigation of bleeding disorders</title><title>International journal of laboratory hematology</title><addtitle>Int J Lab Hematol</addtitle><description>This guidance was prepared on behalf of the International Council for Standardisation in Haematology (ICSH) by an international working group of clinicians and scientists. The document focuses on tests and assays used for the assessment of fibrinogen function, particularly in the scenario of bleeding disorders. Thrombin clotting time (TT) is used as a screening test in some laboratories and also has some utility when direct anticoagulants are in use. The Clauss fibrinogen assay remains the method of choice for the assessment of fibrinogen function, but there are some situations where the results may be misleading. Prothrombin time derived fibrinogen assays are frequently used, but should be interpreted with caution; the results are not interchangeable between different methods and fibrinogen can be overestimated in certain clinical scenarios. Viscoelastic point of care methods may be helpful in emergency situations, while Reptilase time (and similar tests) are useful combined with TT in distinguishing heparin contamination of samples (i.e., if an incorrect blood draw is suspected) and the presence of direct thrombin inhibitors. Fibrinogen antigen assays should be used in the investigation of functional fibrinogen abnormalities; fibrinogen antigen and genetic testing are recommended in the confirmation of congenital fibrinogen disorders. The following recommendations for fibrinogen function assessment are based on published literature and expert opinion and should supplement local regulations and standards.</description><subject>Anticoagulants</subject><subject>Antigens</subject><subject>Bleeding</subject><subject>Blood Coagulation Disorders</subject><subject>Blood Coagulation Tests - methods</subject><subject>Clotting</subject><subject>Contamination</subject><subject>Fibrinogen</subject><subject>Fibrinogen - analysis</subject><subject>fibrinogen assay</subject><subject>Genetic screening</subject><subject>Hematology</subject><subject>Hemophilia</subject><subject>Hemostatics</subject><subject>Heparin</subject><subject>Humans</subject><subject>Prothrombin</subject><subject>Thrombin</subject><subject>Thrombin Time</subject><subject>Viscoelasticity</subject><issn>1751-5521</issn><issn>1751-553X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAQgCMEoqVw4QGQJS4IscV2knV8rCqgi1bqpUjcIv9Mdr1y7GI7oH0tnpBJU3roob7MWPPN55Gnqt4yes7wfHYHvz9nDafsWXXKRMtWbVv_fP6Qc3ZSvcr5QGkrGipfVie1kF3TUXFa_d2EAimo4mJQnpg4BeM8GWIiuahgVbIu31WJC2SvYFQl-rg7kgQmjiMgMlczQWJwOrkQdxCIylkd8ydS9imOGluNj6W4sCPFjUDQjAKvClhSIJc828seMPzGq9stT8aBaA9g5z6cIyYLKb-uXgzKZ3hzH8-qH1-_3FxerbbX3zaXF9uVqWXNVlbLRrQa1h3UHcXciEY2RlplWiP42oqBtbwD2gjdadvogQqrNeO1wk7Q9Vn1YfHepvhrwqn60WUD3qsAcco97yTnAs01ou8foYc44a96pCRru7WkvEHq40KZFHNOMPS3yY0qHXtG-3mT_bzJ_m6TCL-7V056BPuA_l8dAmwB_jgPxydU_eb79mqR_gNtya4q</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Mackie, Ian</creator><creator>Casini, Alessandro</creator><creator>Pieters, Marlien</creator><creator>Pruthi, Rajiv</creator><creator>Reilly‐Stitt, Chris</creator><creator>Suzuki, Atsuo</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7194-3183</orcidid><orcidid>https://orcid.org/0000-0002-7393-2365</orcidid><orcidid>https://orcid.org/0000-0002-6969-929X</orcidid></search><sort><creationdate>202402</creationdate><title>International council for standardisation in haematology recommendations on fibrinogen assays, thrombin clotting time and related tests in the investigation of bleeding disorders</title><author>Mackie, Ian ; Casini, Alessandro ; Pieters, Marlien ; Pruthi, Rajiv ; Reilly‐Stitt, Chris ; Suzuki, Atsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3931-db9475be68e380947c7494c9dac5c726d7f1528e047b8bd4bf07dbb123ab94eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anticoagulants</topic><topic>Antigens</topic><topic>Bleeding</topic><topic>Blood Coagulation Disorders</topic><topic>Blood Coagulation Tests - methods</topic><topic>Clotting</topic><topic>Contamination</topic><topic>Fibrinogen</topic><topic>Fibrinogen - analysis</topic><topic>fibrinogen assay</topic><topic>Genetic screening</topic><topic>Hematology</topic><topic>Hemophilia</topic><topic>Hemostatics</topic><topic>Heparin</topic><topic>Humans</topic><topic>Prothrombin</topic><topic>Thrombin</topic><topic>Thrombin Time</topic><topic>Viscoelasticity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mackie, Ian</creatorcontrib><creatorcontrib>Casini, Alessandro</creatorcontrib><creatorcontrib>Pieters, Marlien</creatorcontrib><creatorcontrib>Pruthi, Rajiv</creatorcontrib><creatorcontrib>Reilly‐Stitt, Chris</creatorcontrib><creatorcontrib>Suzuki, Atsuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of laboratory hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mackie, Ian</au><au>Casini, Alessandro</au><au>Pieters, Marlien</au><au>Pruthi, Rajiv</au><au>Reilly‐Stitt, Chris</au><au>Suzuki, Atsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>International council for standardisation in haematology recommendations on fibrinogen assays, thrombin clotting time and related tests in the investigation of bleeding disorders</atitle><jtitle>International journal of laboratory hematology</jtitle><addtitle>Int J Lab Hematol</addtitle><date>2024-02</date><risdate>2024</risdate><volume>46</volume><issue>1</issue><spage>20</spage><epage>32</epage><pages>20-32</pages><issn>1751-5521</issn><eissn>1751-553X</eissn><abstract>This guidance was prepared on behalf of the International Council for Standardisation in Haematology (ICSH) by an international working group of clinicians and scientists. The document focuses on tests and assays used for the assessment of fibrinogen function, particularly in the scenario of bleeding disorders. Thrombin clotting time (TT) is used as a screening test in some laboratories and also has some utility when direct anticoagulants are in use. The Clauss fibrinogen assay remains the method of choice for the assessment of fibrinogen function, but there are some situations where the results may be misleading. Prothrombin time derived fibrinogen assays are frequently used, but should be interpreted with caution; the results are not interchangeable between different methods and fibrinogen can be overestimated in certain clinical scenarios. Viscoelastic point of care methods may be helpful in emergency situations, while Reptilase time (and similar tests) are useful combined with TT in distinguishing heparin contamination of samples (i.e., if an incorrect blood draw is suspected) and the presence of direct thrombin inhibitors. 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subjects | Anticoagulants Antigens Bleeding Blood Coagulation Disorders Blood Coagulation Tests - methods Clotting Contamination Fibrinogen Fibrinogen - analysis fibrinogen assay Genetic screening Hematology Hemophilia Hemostatics Heparin Humans Prothrombin Thrombin Thrombin Time Viscoelasticity |
title | International council for standardisation in haematology recommendations on fibrinogen assays, thrombin clotting time and related tests in the investigation of bleeding disorders |
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