Obesity is an independent risk factor for cancer development following diagnosis of dermatomyositis
Patients with dermatomyositis (DM) are at an increased risk of cancer development, especially around the time of diagnosis of DM. Obesity is also a risk factor in the general population for cancer development. This study aimed to assess the association between cancer in DM patients with and without...
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| Veröffentlicht in: | Seminars in arthritis and rheumatism 2024-02, Vol.64, p.152283-152283, Article 152283 |
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| container_title | Seminars in arthritis and rheumatism |
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| creator | Allenzara, Astia Sadeghi, Nakisa Alvarez, Carolina Maczuga, Steve Helm, Matthew Olsen, Nancy Nelson, Amanda Foulke, Galen |
| description | Patients with dermatomyositis (DM) are at an increased risk of cancer development, especially around the time of diagnosis of DM. Obesity is also a risk factor in the general population for cancer development. This study aimed to assess the association between cancer in DM patients with and without obesity as defined by ICD code and BMI data. In this analysis of patients with DM, logistic regression modeling of the odds of cancer outcome was performed for patients with DM and obesity compared to those without obesity, adjusted for age and sex. A total of 12,722 patients with DM were identified, of whom 6,055 had available BMI data. DM patients who were coded obese at any point had significantly higher odds 1.98 (95 % Confidence interval (CI) 1.70, 2.30) of a subsequent cancer diagnosis. This association was also found in the subgroup analysis with available BMI where patients with obesity (BMI ≥30 kg/m
) had an increased odds of cancer 1.23 (1.02, 1.49) when compared to patients with BMI |
| doi_str_mv | 10.1016/j.semarthrit.2023.152283 |
| format | Article |
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) had an increased odds of cancer 1.23 (1.02, 1.49) when compared to patients with BMI <30 kg/m
with DM. In time to event analysis any obesity code was associated with a 16 % increased hazard of cancer (adjusted hazard ratio 1.16 [95 % CI 1.02, 1.31]). Overall, the most frequent type of cancer was breast cancer, however patients with DM and obesity had higher frequencies of lymphoma, colorectal, melanoma, uterine, renal cancers compared to patients with DM without obesity.</description><identifier>ISSN: 0049-0172</identifier><identifier>EISSN: 1532-866X</identifier><identifier>DOI: 10.1016/j.semarthrit.2023.152283</identifier><identifier>PMID: 37984228</identifier><language>eng</language><publisher>United States</publisher><ispartof>Seminars in arthritis and rheumatism, 2024-02, Vol.64, p.152283-152283, Article 152283</ispartof><rights>Copyright © 2023. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c260t-6f256a94def1f7502a1a3000f2405186d35e589f1c5f549bd8cb8b0ab63b9b203</cites><orcidid>0000-0003-2212-009X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37984228$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Allenzara, Astia</creatorcontrib><creatorcontrib>Sadeghi, Nakisa</creatorcontrib><creatorcontrib>Alvarez, Carolina</creatorcontrib><creatorcontrib>Maczuga, Steve</creatorcontrib><creatorcontrib>Helm, Matthew</creatorcontrib><creatorcontrib>Olsen, Nancy</creatorcontrib><creatorcontrib>Nelson, Amanda</creatorcontrib><creatorcontrib>Foulke, Galen</creatorcontrib><title>Obesity is an independent risk factor for cancer development following diagnosis of dermatomyositis</title><title>Seminars in arthritis and rheumatism</title><addtitle>Semin Arthritis Rheum</addtitle><description>Patients with dermatomyositis (DM) are at an increased risk of cancer development, especially around the time of diagnosis of DM. Obesity is also a risk factor in the general population for cancer development. This study aimed to assess the association between cancer in DM patients with and without obesity as defined by ICD code and BMI data. In this analysis of patients with DM, logistic regression modeling of the odds of cancer outcome was performed for patients with DM and obesity compared to those without obesity, adjusted for age and sex. A total of 12,722 patients with DM were identified, of whom 6,055 had available BMI data. DM patients who were coded obese at any point had significantly higher odds 1.98 (95 % Confidence interval (CI) 1.70, 2.30) of a subsequent cancer diagnosis. This association was also found in the subgroup analysis with available BMI where patients with obesity (BMI ≥30 kg/m
) had an increased odds of cancer 1.23 (1.02, 1.49) when compared to patients with BMI <30 kg/m
with DM. In time to event analysis any obesity code was associated with a 16 % increased hazard of cancer (adjusted hazard ratio 1.16 [95 % CI 1.02, 1.31]). Overall, the most frequent type of cancer was breast cancer, however patients with DM and obesity had higher frequencies of lymphoma, colorectal, melanoma, uterine, renal cancers compared to patients with DM without obesity.</description><issn>0049-0172</issn><issn>1532-866X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpFkE1LAzEQhoMoWqt_QXL0snWSbNLsUYpfUPCi4C1ks4mm7m5qkir996bUj8PMwPC8M_AghAnMCBBxtZolO-iY36LPMwqUzQinVLIDNCGc0UoK8XKIJgB1UwGZ0xN0mtIKgBAB82N0wuaNrEtggsxja5PPW-wT1iP2Y2fXtrQx4-jTO3ba5BCxK2X0aGzEnf20fVgPO8SFvg9ffnzFndevY0jlSnAFiYPOYdiWRfbpDB053Sd7_jOn6Pn25mlxXy0f7x4W18vKUAG5Eo5yoZu6s464OQeqiWYA4GgNnEjRMW65bBwx3PG6aTtpWtmCbgVrm5YCm6LL_d11DB8bm7IafDK27_VowyYpKhtKhWSUFlTuURNDStE6tY6-GN0qAmqnWK3Uv2K1U6z2ikv04ufLph1s9xf8dcq-AZJafXc</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Allenzara, Astia</creator><creator>Sadeghi, Nakisa</creator><creator>Alvarez, Carolina</creator><creator>Maczuga, Steve</creator><creator>Helm, Matthew</creator><creator>Olsen, Nancy</creator><creator>Nelson, Amanda</creator><creator>Foulke, Galen</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2212-009X</orcidid></search><sort><creationdate>202402</creationdate><title>Obesity is an independent risk factor for cancer development following diagnosis of dermatomyositis</title><author>Allenzara, Astia ; Sadeghi, Nakisa ; Alvarez, Carolina ; Maczuga, Steve ; Helm, Matthew ; Olsen, Nancy ; Nelson, Amanda ; Foulke, Galen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c260t-6f256a94def1f7502a1a3000f2405186d35e589f1c5f549bd8cb8b0ab63b9b203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allenzara, Astia</creatorcontrib><creatorcontrib>Sadeghi, Nakisa</creatorcontrib><creatorcontrib>Alvarez, Carolina</creatorcontrib><creatorcontrib>Maczuga, Steve</creatorcontrib><creatorcontrib>Helm, Matthew</creatorcontrib><creatorcontrib>Olsen, Nancy</creatorcontrib><creatorcontrib>Nelson, Amanda</creatorcontrib><creatorcontrib>Foulke, Galen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Seminars in arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allenzara, Astia</au><au>Sadeghi, Nakisa</au><au>Alvarez, Carolina</au><au>Maczuga, Steve</au><au>Helm, Matthew</au><au>Olsen, Nancy</au><au>Nelson, Amanda</au><au>Foulke, Galen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity is an independent risk factor for cancer development following diagnosis of dermatomyositis</atitle><jtitle>Seminars in arthritis and rheumatism</jtitle><addtitle>Semin Arthritis Rheum</addtitle><date>2024-02</date><risdate>2024</risdate><volume>64</volume><spage>152283</spage><epage>152283</epage><pages>152283-152283</pages><artnum>152283</artnum><issn>0049-0172</issn><eissn>1532-866X</eissn><abstract>Patients with dermatomyositis (DM) are at an increased risk of cancer development, especially around the time of diagnosis of DM. Obesity is also a risk factor in the general population for cancer development. This study aimed to assess the association between cancer in DM patients with and without obesity as defined by ICD code and BMI data. In this analysis of patients with DM, logistic regression modeling of the odds of cancer outcome was performed for patients with DM and obesity compared to those without obesity, adjusted for age and sex. A total of 12,722 patients with DM were identified, of whom 6,055 had available BMI data. DM patients who were coded obese at any point had significantly higher odds 1.98 (95 % Confidence interval (CI) 1.70, 2.30) of a subsequent cancer diagnosis. This association was also found in the subgroup analysis with available BMI where patients with obesity (BMI ≥30 kg/m
) had an increased odds of cancer 1.23 (1.02, 1.49) when compared to patients with BMI <30 kg/m
with DM. In time to event analysis any obesity code was associated with a 16 % increased hazard of cancer (adjusted hazard ratio 1.16 [95 % CI 1.02, 1.31]). Overall, the most frequent type of cancer was breast cancer, however patients with DM and obesity had higher frequencies of lymphoma, colorectal, melanoma, uterine, renal cancers compared to patients with DM without obesity.</abstract><cop>United States</cop><pmid>37984228</pmid><doi>10.1016/j.semarthrit.2023.152283</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-2212-009X</orcidid></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| title | Obesity is an independent risk factor for cancer development following diagnosis of dermatomyositis |
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