Self‐assembled pea vicilin nanoparticles as nanocarriers for improving the antioxidant activity, environmental stability and sustained‐release property of curcumin
BACKGROUND The application of curcumin (Cur) in the food industry is usually limited by its low water solubility and poor stability. This study aimed to fabricate self‐assembled nanoparticles using pea vicilin (7S) through a pH‐shifting method (pH 7–pH 12–pH 7) to develop water‐soluble nanocarriers...
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| Veröffentlicht in: | Journal of the science of food and agriculture 2024-03, Vol.104 (4), p.2467-2476 |
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| container_title | Journal of the science of food and agriculture |
| container_volume | 104 |
| creator | Liu, Huihui Wang, Zijun Xu, Jingjing Ji, Fuyun Luo, Shuizhong Zhong, Xiyang Zhao, Yanyan Zheng, Zhi |
| description | BACKGROUND
The application of curcumin (Cur) in the food industry is usually limited by its low water solubility and poor stability. This study aimed to fabricate self‐assembled nanoparticles using pea vicilin (7S) through a pH‐shifting method (pH 7–pH 12–pH 7) to develop water‐soluble nanocarriers of Cur.
RESULTS
Intrinsic fluorescence, far‐UV circular dichroism spectra and transmission electron microscopy analysis demonstrated that the structure of 7S could be unfolded at pH 12.0 and refolded when the pH shifted to 7.0. The assembled 7S–Cur exhibited a high loading ability of 81.63 μg mg−1 for Cur and homogeneous particle distribution. Cur was encapsulated in the 7S hydrophobic nucleus in an amorphous form and combined through hydrophobic interactions and hydrogen bonding, resulting in the static fluorescence quenching of 7S. Compared with free Cur, the retention rates of Cur in 7S–Cur were approximately 1.12 and 1.70 times higher under UV exposure at 365 nm or heating at 75 °C for 120 min, respectively, as well as 7S–Cur showing approximately 1.50 times higher antioxidant activity. During simulated gastrointestinal experiments, 7S–Cur exhibited a better sustained‐release property than free Cur.
CONCLUSION
The self‐assembled 7S nanocarriers prepared using a pH‐shifting method effectively improved the antioxidant activity, environmental stability and sustained‐release property of Cur. Therefore, 7S isolated from pea protein could be used as potential nanocarriers for Cur. © 2023 Society of Chemical Industry. |
| doi_str_mv | 10.1002/jsfa.13132 |
| format | Article |
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The application of curcumin (Cur) in the food industry is usually limited by its low water solubility and poor stability. This study aimed to fabricate self‐assembled nanoparticles using pea vicilin (7S) through a pH‐shifting method (pH 7–pH 12–pH 7) to develop water‐soluble nanocarriers of Cur.
RESULTS
Intrinsic fluorescence, far‐UV circular dichroism spectra and transmission electron microscopy analysis demonstrated that the structure of 7S could be unfolded at pH 12.0 and refolded when the pH shifted to 7.0. The assembled 7S–Cur exhibited a high loading ability of 81.63 μg mg−1 for Cur and homogeneous particle distribution. Cur was encapsulated in the 7S hydrophobic nucleus in an amorphous form and combined through hydrophobic interactions and hydrogen bonding, resulting in the static fluorescence quenching of 7S. Compared with free Cur, the retention rates of Cur in 7S–Cur were approximately 1.12 and 1.70 times higher under UV exposure at 365 nm or heating at 75 °C for 120 min, respectively, as well as 7S–Cur showing approximately 1.50 times higher antioxidant activity. During simulated gastrointestinal experiments, 7S–Cur exhibited a better sustained‐release property than free Cur.
CONCLUSION
The self‐assembled 7S nanocarriers prepared using a pH‐shifting method effectively improved the antioxidant activity, environmental stability and sustained‐release property of Cur. Therefore, 7S isolated from pea protein could be used as potential nanocarriers for Cur. © 2023 Society of Chemical Industry.</description><identifier>ISSN: 0022-5142</identifier><identifier>EISSN: 1097-0010</identifier><identifier>DOI: 10.1002/jsfa.13132</identifier><identifier>PMID: 37986244</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Antioxidants ; Circular dichroism ; Curcumin ; Curcumin - chemistry ; Delayed-Action Preparations ; Dichroism ; Drug Carriers - chemistry ; Fluorescence ; Food industry ; Hydrogen bonding ; Hydrophobicity ; nanocomplexes ; Nanoparticles ; Nanoparticles - chemistry ; Particle Size ; pea vicilin ; Peas ; pH effects ; pH‐shifting ; Pisum sativum ; Seed Storage Proteins ; Self-assembly ; Stability ; Transmission electron microscopy ; Ultraviolet radiation ; Water</subject><ispartof>Journal of the science of food and agriculture, 2024-03, Vol.104 (4), p.2467-2476</ispartof><rights>2023 Society of Chemical Industry.</rights><rights>Copyright © 2024 Society of Chemical Industry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3522-6ff84494e18e3b418215e9534ee27dbe89292f1b5798ddef49a3037d110b95843</cites><orcidid>0000-0002-6663-5936 ; 0000-0003-4879-2732</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjsfa.13132$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjsfa.13132$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37986244$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Huihui</creatorcontrib><creatorcontrib>Wang, Zijun</creatorcontrib><creatorcontrib>Xu, Jingjing</creatorcontrib><creatorcontrib>Ji, Fuyun</creatorcontrib><creatorcontrib>Luo, Shuizhong</creatorcontrib><creatorcontrib>Zhong, Xiyang</creatorcontrib><creatorcontrib>Zhao, Yanyan</creatorcontrib><creatorcontrib>Zheng, Zhi</creatorcontrib><title>Self‐assembled pea vicilin nanoparticles as nanocarriers for improving the antioxidant activity, environmental stability and sustained‐release property of curcumin</title><title>Journal of the science of food and agriculture</title><addtitle>J Sci Food Agric</addtitle><description>BACKGROUND
The application of curcumin (Cur) in the food industry is usually limited by its low water solubility and poor stability. This study aimed to fabricate self‐assembled nanoparticles using pea vicilin (7S) through a pH‐shifting method (pH 7–pH 12–pH 7) to develop water‐soluble nanocarriers of Cur.
RESULTS
Intrinsic fluorescence, far‐UV circular dichroism spectra and transmission electron microscopy analysis demonstrated that the structure of 7S could be unfolded at pH 12.0 and refolded when the pH shifted to 7.0. The assembled 7S–Cur exhibited a high loading ability of 81.63 μg mg−1 for Cur and homogeneous particle distribution. Cur was encapsulated in the 7S hydrophobic nucleus in an amorphous form and combined through hydrophobic interactions and hydrogen bonding, resulting in the static fluorescence quenching of 7S. Compared with free Cur, the retention rates of Cur in 7S–Cur were approximately 1.12 and 1.70 times higher under UV exposure at 365 nm or heating at 75 °C for 120 min, respectively, as well as 7S–Cur showing approximately 1.50 times higher antioxidant activity. During simulated gastrointestinal experiments, 7S–Cur exhibited a better sustained‐release property than free Cur.
CONCLUSION
The self‐assembled 7S nanocarriers prepared using a pH‐shifting method effectively improved the antioxidant activity, environmental stability and sustained‐release property of Cur. Therefore, 7S isolated from pea protein could be used as potential nanocarriers for Cur. © 2023 Society of Chemical Industry.</description><subject>Antioxidants</subject><subject>Circular dichroism</subject><subject>Curcumin</subject><subject>Curcumin - chemistry</subject><subject>Delayed-Action Preparations</subject><subject>Dichroism</subject><subject>Drug Carriers - chemistry</subject><subject>Fluorescence</subject><subject>Food industry</subject><subject>Hydrogen bonding</subject><subject>Hydrophobicity</subject><subject>nanocomplexes</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Particle Size</subject><subject>pea vicilin</subject><subject>Peas</subject><subject>pH effects</subject><subject>pH‐shifting</subject><subject>Pisum sativum</subject><subject>Seed Storage Proteins</subject><subject>Self-assembly</subject><subject>Stability</subject><subject>Transmission electron microscopy</subject><subject>Ultraviolet radiation</subject><subject>Water</subject><issn>0022-5142</issn><issn>1097-0010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uFSEYhomxsafVjRdgSNyYxlP5mx-WTWP9SRMX1fWEgQ_lhIERmKNn10voXXhfvRJpT3XhwtUX4MnDCy9Czyk5pYSwN5ts1SnllLNHaEWJ7NaEUPIYreohWzdUsEN0lPOGECJl2z5Bh7yTfcuEWKFfV-Dt7fWNyhmm0YPBMyi8ddp5F3BQIc4qFac9ZKzy_YZWKTlIGduYsJvmFLcufMXlG2AVios_nakTK13c1pXdawxh61IME4SiPM5FjVVedpU2OC917QKYmiGBB5UBV-MMqQLRYr0kvUwuPEUHVvkMzx7mMfpy8fbz-fv15ad3H87PLteaN_WxrbW9EFIA7YGPgvaMNiAbLgBYZ0boJZPM0rGpH2AMWCEVJ7wzlJJRNr3gx-jV3ltDfF8gl2FyWYP3KkBc8sCqgbVdR_uKvvwH3cQlhZpuqJfwtu2paCp1sqd0ijknsMOc3KTSbqBkuKtvuKtvuK-vwi8elMs4gfmL_umrAnQP_HAedv9RDR-vLs720t_O_qr0</recordid><startdate>20240315</startdate><enddate>20240315</enddate><creator>Liu, Huihui</creator><creator>Wang, Zijun</creator><creator>Xu, Jingjing</creator><creator>Ji, Fuyun</creator><creator>Luo, Shuizhong</creator><creator>Zhong, Xiyang</creator><creator>Zhao, Yanyan</creator><creator>Zheng, Zhi</creator><general>John Wiley & Sons, Ltd</general><general>John Wiley and Sons, Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QL</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6663-5936</orcidid><orcidid>https://orcid.org/0000-0003-4879-2732</orcidid></search><sort><creationdate>20240315</creationdate><title>Self‐assembled pea vicilin nanoparticles as nanocarriers for improving the antioxidant activity, environmental stability and sustained‐release property of curcumin</title><author>Liu, Huihui ; Wang, Zijun ; Xu, Jingjing ; Ji, Fuyun ; Luo, Shuizhong ; Zhong, Xiyang ; Zhao, Yanyan ; Zheng, Zhi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3522-6ff84494e18e3b418215e9534ee27dbe89292f1b5798ddef49a3037d110b95843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antioxidants</topic><topic>Circular dichroism</topic><topic>Curcumin</topic><topic>Curcumin - chemistry</topic><topic>Delayed-Action Preparations</topic><topic>Dichroism</topic><topic>Drug Carriers - chemistry</topic><topic>Fluorescence</topic><topic>Food industry</topic><topic>Hydrogen bonding</topic><topic>Hydrophobicity</topic><topic>nanocomplexes</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Particle Size</topic><topic>pea vicilin</topic><topic>Peas</topic><topic>pH effects</topic><topic>pH‐shifting</topic><topic>Pisum sativum</topic><topic>Seed Storage Proteins</topic><topic>Self-assembly</topic><topic>Stability</topic><topic>Transmission electron microscopy</topic><topic>Ultraviolet radiation</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Huihui</creatorcontrib><creatorcontrib>Wang, Zijun</creatorcontrib><creatorcontrib>Xu, Jingjing</creatorcontrib><creatorcontrib>Ji, Fuyun</creatorcontrib><creatorcontrib>Luo, Shuizhong</creatorcontrib><creatorcontrib>Zhong, Xiyang</creatorcontrib><creatorcontrib>Zhao, Yanyan</creatorcontrib><creatorcontrib>Zheng, Zhi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the science of food and agriculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Huihui</au><au>Wang, Zijun</au><au>Xu, Jingjing</au><au>Ji, Fuyun</au><au>Luo, Shuizhong</au><au>Zhong, Xiyang</au><au>Zhao, Yanyan</au><au>Zheng, Zhi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Self‐assembled pea vicilin nanoparticles as nanocarriers for improving the antioxidant activity, environmental stability and sustained‐release property of curcumin</atitle><jtitle>Journal of the science of food and agriculture</jtitle><addtitle>J Sci Food Agric</addtitle><date>2024-03-15</date><risdate>2024</risdate><volume>104</volume><issue>4</issue><spage>2467</spage><epage>2476</epage><pages>2467-2476</pages><issn>0022-5142</issn><eissn>1097-0010</eissn><abstract>BACKGROUND
The application of curcumin (Cur) in the food industry is usually limited by its low water solubility and poor stability. This study aimed to fabricate self‐assembled nanoparticles using pea vicilin (7S) through a pH‐shifting method (pH 7–pH 12–pH 7) to develop water‐soluble nanocarriers of Cur.
RESULTS
Intrinsic fluorescence, far‐UV circular dichroism spectra and transmission electron microscopy analysis demonstrated that the structure of 7S could be unfolded at pH 12.0 and refolded when the pH shifted to 7.0. The assembled 7S–Cur exhibited a high loading ability of 81.63 μg mg−1 for Cur and homogeneous particle distribution. Cur was encapsulated in the 7S hydrophobic nucleus in an amorphous form and combined through hydrophobic interactions and hydrogen bonding, resulting in the static fluorescence quenching of 7S. Compared with free Cur, the retention rates of Cur in 7S–Cur were approximately 1.12 and 1.70 times higher under UV exposure at 365 nm or heating at 75 °C for 120 min, respectively, as well as 7S–Cur showing approximately 1.50 times higher antioxidant activity. During simulated gastrointestinal experiments, 7S–Cur exhibited a better sustained‐release property than free Cur.
CONCLUSION
The self‐assembled 7S nanocarriers prepared using a pH‐shifting method effectively improved the antioxidant activity, environmental stability and sustained‐release property of Cur. Therefore, 7S isolated from pea protein could be used as potential nanocarriers for Cur. © 2023 Society of Chemical Industry.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>37986244</pmid><doi>10.1002/jsfa.13132</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-6663-5936</orcidid><orcidid>https://orcid.org/0000-0003-4879-2732</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antioxidants Circular dichroism Curcumin Curcumin - chemistry Delayed-Action Preparations Dichroism Drug Carriers - chemistry Fluorescence Food industry Hydrogen bonding Hydrophobicity nanocomplexes Nanoparticles Nanoparticles - chemistry Particle Size pea vicilin Peas pH effects pH‐shifting Pisum sativum Seed Storage Proteins Self-assembly Stability Transmission electron microscopy Ultraviolet radiation Water |
| title | Self‐assembled pea vicilin nanoparticles as nanocarriers for improving the antioxidant activity, environmental stability and sustained‐release property of curcumin |
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