Mechanistic and thermodynamic characterization of antiviral inhibitors targeting nucleocapsid N-terminal domain of SARS-CoV-2

The nucleocapsid (N) protein of SARS-CoV-2 plays a pivotal role in encapsulating the viral genome. Developing antiviral treatments for SARS-CoV-2 is imperative due to the diminishing immunity of the available vaccines. This study targets the RNA-binding site located in the N-terminal domain (NTD) of...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2023-12, Vol.750, p.109820-109820, Article 109820
Hauptverfasser:	Dhaka, Preeti, Singh, Ankur, Choudhary, Shweta, Peddinti, Rama Krishna, Kumar, Pravindra, Sharma, Gaurav Kumar, Tomar, Shailly
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - chemistry Antiviral Agents - pharmacology COVID-19 Humans Molecular Docking Simulation Nucleocapsid - metabolism Post-Acute COVID-19 Syndrome RNA SARS-CoV-2 Thermodynamics
Online-Zugang:	Volltext
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