Management of Choroid Plexus Tumors and the Benefit of Preoperative Embolization in Pediatric Patients: Report of 46 Cases from a Single Institution
Optimal choroid plexus tumor (CPT) treatment involves gross total resection; however, intraoperative hemorrhage risk remains significant given tumor vascularity. This study describes pediatric CPT management and identifies patients most likely to benefit from preoperative embolization. CPTs resected...
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| Veröffentlicht in: | World neurosurgery 2024-01, Vol.181, p.e1071-e1087 |
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| creator | Slingerland, Anna L. Papadakis, Joanna E. Staffa, Steven J. Scott, R. Michael See, Alfred P. Orbach, Darren B. Fehnel, Katie P. |
| description | Optimal choroid plexus tumor (CPT) treatment involves gross total resection; however, intraoperative hemorrhage risk remains significant given tumor vascularity. This study describes pediatric CPT management and identifies patients most likely to benefit from preoperative embolization.
CPTs resected from 1997 to 2021 were included. The characteristics of embolized patients were compared to nonembolized patients; nonembolized patients were further stratified based on open vascular control-pedicle feeder ligation versus no pedicle ligation prior to tumor debulking. Statistical analyses identified factors associated with estimated blood loss (EBL), transfusion, length of stay, and complications.
Among the 46 CPT cases identified, 98% achieved gross total resection, and 15% received embolization. Embolized patients were younger, smaller, and had larger tumors compared to nonembolized patients (median: 0.8 vs. 2.1 years; 9.3 vs. 14.4 kg; 91.08 vs. 5.5 cm3). Transfused patients were similarly younger and smaller (P < 0.05) than nontransfused patients. Among nonembolized patients, open vascular control was achieved in smaller tumors ( |
| doi_str_mv | 10.1016/j.wneu.2023.11.044 |
| format | Article |
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CPTs resected from 1997 to 2021 were included. The characteristics of embolized patients were compared to nonembolized patients; nonembolized patients were further stratified based on open vascular control-pedicle feeder ligation versus no pedicle ligation prior to tumor debulking. Statistical analyses identified factors associated with estimated blood loss (EBL), transfusion, length of stay, and complications.
Among the 46 CPT cases identified, 98% achieved gross total resection, and 15% received embolization. Embolized patients were younger, smaller, and had larger tumors compared to nonembolized patients (median: 0.8 vs. 2.1 years; 9.3 vs. 14.4 kg; 91.08 vs. 5.5 cm3). Transfused patients were similarly younger and smaller (P < 0.05) than nontransfused patients. Among nonembolized patients, open vascular control was achieved in smaller tumors (<13 cm3) with significantly lower EBL (P = 0.002). Higher EBL was observed in patients with larger tumors, hydrocephalus, transependymal edema, vomiting, lethargy, and developmental regression (all P < 0.05). Patients with lethargy had longer hospital stays and a higher likelihood of postoperative complications (P < 0.05). There were no significant differences in complication rates between the embolization and nonembolization groups.
Despite higher surgical risk profiles, embolized patients had similar complication rates and postoperative hydrocephalus management as nonembolized patients. Embolization was particularly beneficial in patients at high risk for surgical morbidity, such as those <2 years, weighing <10 kg, and with a tumor volume >15 cm3.]]></description><identifier>ISSN: 1878-8750</identifier><identifier>ISSN: 1878-8769</identifier><identifier>EISSN: 1878-8769</identifier><identifier>DOI: 10.1016/j.wneu.2023.11.044</identifier><identifier>PMID: 37977483</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Choroid plexus carcinoma ; Choroid plexus papilloma ; Choroid plexus tumors ; Embolization ; Pediatrics</subject><ispartof>World neurosurgery, 2024-01, Vol.181, p.e1071-e1087</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c307t-313548b4a18c1ec1d7c84498bbeea89e16d4ef964bbde5080ac6f72e5025f3b33</cites><orcidid>0000-0001-7216-757X ; 0000-0002-1793-3398 ; 0000-0002-3058-3513 ; 0000-0002-7588-7596</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1878875023016078$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37977483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Slingerland, Anna L.</creatorcontrib><creatorcontrib>Papadakis, Joanna E.</creatorcontrib><creatorcontrib>Staffa, Steven J.</creatorcontrib><creatorcontrib>Scott, R. Michael</creatorcontrib><creatorcontrib>See, Alfred P.</creatorcontrib><creatorcontrib>Orbach, Darren B.</creatorcontrib><creatorcontrib>Fehnel, Katie P.</creatorcontrib><title>Management of Choroid Plexus Tumors and the Benefit of Preoperative Embolization in Pediatric Patients: Report of 46 Cases from a Single Institution</title><title>World neurosurgery</title><addtitle>World Neurosurg</addtitle><description><![CDATA[Optimal choroid plexus tumor (CPT) treatment involves gross total resection; however, intraoperative hemorrhage risk remains significant given tumor vascularity. This study describes pediatric CPT management and identifies patients most likely to benefit from preoperative embolization.
CPTs resected from 1997 to 2021 were included. The characteristics of embolized patients were compared to nonembolized patients; nonembolized patients were further stratified based on open vascular control-pedicle feeder ligation versus no pedicle ligation prior to tumor debulking. Statistical analyses identified factors associated with estimated blood loss (EBL), transfusion, length of stay, and complications.
Among the 46 CPT cases identified, 98% achieved gross total resection, and 15% received embolization. Embolized patients were younger, smaller, and had larger tumors compared to nonembolized patients (median: 0.8 vs. 2.1 years; 9.3 vs. 14.4 kg; 91.08 vs. 5.5 cm3). Transfused patients were similarly younger and smaller (P < 0.05) than nontransfused patients. Among nonembolized patients, open vascular control was achieved in smaller tumors (<13 cm3) with significantly lower EBL (P = 0.002). Higher EBL was observed in patients with larger tumors, hydrocephalus, transependymal edema, vomiting, lethargy, and developmental regression (all P < 0.05). Patients with lethargy had longer hospital stays and a higher likelihood of postoperative complications (P < 0.05). There were no significant differences in complication rates between the embolization and nonembolization groups.
Despite higher surgical risk profiles, embolized patients had similar complication rates and postoperative hydrocephalus management as nonembolized patients. Embolization was particularly beneficial in patients at high risk for surgical morbidity, such as those <2 years, weighing <10 kg, and with a tumor volume >15 cm3.]]></description><subject>Choroid plexus carcinoma</subject><subject>Choroid plexus papilloma</subject><subject>Choroid plexus tumors</subject><subject>Embolization</subject><subject>Pediatrics</subject><issn>1878-8750</issn><issn>1878-8769</issn><issn>1878-8769</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAUhS0EolXpC7BAd8lmgh07sYPYwKjQSkWMoKwtx7lpPUrswXbKz3PwwPV0Spd442vrnE-65xDyktGKUda-2VY_PS5VTWteMVZRIZ6QY6akWinZdk8f54YekdOUtrQczoSS_Dk54rKTUih-TP5-Nt5c44w-QxhhfRNicANsJvy1JLha5hATGD9AvkH4gB5Hdy_cRAw7jCa7W4SzuQ-T-1MewYPzsMHBmRydhU35K-j0Fr7iLsR7q2hhbRImGGOYwcA3568nhAufssvLnvGCPBvNlPD04T4h3z-eXa3PV5dfPl2s31-uLKcyrzjjjVC9MExZhpYN0iohOtX3iEZ1yNpB4Ni1ou8HbKiixrajrMtYNyPvOT8hrw_cXQw_FkxZzy5ZnCbjMSxJ16pjslFKtEVaH6Q2hpQijnoX3Wzib82o3heit3pfiN4XohnTpZBievXAX_oZh0fLv_iL4N1BgGXLW4dRJ1vysiW_iDbrIbj_8e8AsJGeYA</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Slingerland, Anna L.</creator><creator>Papadakis, Joanna E.</creator><creator>Staffa, Steven J.</creator><creator>Scott, R. Michael</creator><creator>See, Alfred P.</creator><creator>Orbach, Darren B.</creator><creator>Fehnel, Katie P.</creator><general>Elsevier Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7216-757X</orcidid><orcidid>https://orcid.org/0000-0002-1793-3398</orcidid><orcidid>https://orcid.org/0000-0002-3058-3513</orcidid><orcidid>https://orcid.org/0000-0002-7588-7596</orcidid></search><sort><creationdate>202401</creationdate><title>Management of Choroid Plexus Tumors and the Benefit of Preoperative Embolization in Pediatric Patients: Report of 46 Cases from a Single Institution</title><author>Slingerland, Anna L. ; Papadakis, Joanna E. ; Staffa, Steven J. ; Scott, R. Michael ; See, Alfred P. ; Orbach, Darren B. ; Fehnel, Katie P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-313548b4a18c1ec1d7c84498bbeea89e16d4ef964bbde5080ac6f72e5025f3b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Choroid plexus carcinoma</topic><topic>Choroid plexus papilloma</topic><topic>Choroid plexus tumors</topic><topic>Embolization</topic><topic>Pediatrics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Slingerland, Anna L.</creatorcontrib><creatorcontrib>Papadakis, Joanna E.</creatorcontrib><creatorcontrib>Staffa, Steven J.</creatorcontrib><creatorcontrib>Scott, R. Michael</creatorcontrib><creatorcontrib>See, Alfred P.</creatorcontrib><creatorcontrib>Orbach, Darren B.</creatorcontrib><creatorcontrib>Fehnel, Katie P.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>World neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Slingerland, Anna L.</au><au>Papadakis, Joanna E.</au><au>Staffa, Steven J.</au><au>Scott, R. Michael</au><au>See, Alfred P.</au><au>Orbach, Darren B.</au><au>Fehnel, Katie P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management of Choroid Plexus Tumors and the Benefit of Preoperative Embolization in Pediatric Patients: Report of 46 Cases from a Single Institution</atitle><jtitle>World neurosurgery</jtitle><addtitle>World Neurosurg</addtitle><date>2024-01</date><risdate>2024</risdate><volume>181</volume><spage>e1071</spage><epage>e1087</epage><pages>e1071-e1087</pages><issn>1878-8750</issn><issn>1878-8769</issn><eissn>1878-8769</eissn><abstract><![CDATA[Optimal choroid plexus tumor (CPT) treatment involves gross total resection; however, intraoperative hemorrhage risk remains significant given tumor vascularity. This study describes pediatric CPT management and identifies patients most likely to benefit from preoperative embolization.
CPTs resected from 1997 to 2021 were included. The characteristics of embolized patients were compared to nonembolized patients; nonembolized patients were further stratified based on open vascular control-pedicle feeder ligation versus no pedicle ligation prior to tumor debulking. Statistical analyses identified factors associated with estimated blood loss (EBL), transfusion, length of stay, and complications.
Among the 46 CPT cases identified, 98% achieved gross total resection, and 15% received embolization. Embolized patients were younger, smaller, and had larger tumors compared to nonembolized patients (median: 0.8 vs. 2.1 years; 9.3 vs. 14.4 kg; 91.08 vs. 5.5 cm3). Transfused patients were similarly younger and smaller (P < 0.05) than nontransfused patients. Among nonembolized patients, open vascular control was achieved in smaller tumors (<13 cm3) with significantly lower EBL (P = 0.002). Higher EBL was observed in patients with larger tumors, hydrocephalus, transependymal edema, vomiting, lethargy, and developmental regression (all P < 0.05). Patients with lethargy had longer hospital stays and a higher likelihood of postoperative complications (P < 0.05). There were no significant differences in complication rates between the embolization and nonembolization groups.
Despite higher surgical risk profiles, embolized patients had similar complication rates and postoperative hydrocephalus management as nonembolized patients. Embolization was particularly beneficial in patients at high risk for surgical morbidity, such as those <2 years, weighing <10 kg, and with a tumor volume >15 cm3.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37977483</pmid><doi>10.1016/j.wneu.2023.11.044</doi><orcidid>https://orcid.org/0000-0001-7216-757X</orcidid><orcidid>https://orcid.org/0000-0002-1793-3398</orcidid><orcidid>https://orcid.org/0000-0002-3058-3513</orcidid><orcidid>https://orcid.org/0000-0002-7588-7596</orcidid></addata></record> |
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| subjects | Choroid plexus carcinoma Choroid plexus papilloma Choroid plexus tumors Embolization Pediatrics |
| title | Management of Choroid Plexus Tumors and the Benefit of Preoperative Embolization in Pediatric Patients: Report of 46 Cases from a Single Institution |
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