Nutrimetric Validation of Solanidine as Dietary‐Derived CYP2D6 Activity Marker In Vivo

CYP2D6 is involved in the metabolism of many drugs. Its activity is affected by pharmacogenetic variability leading to highly polymorphic phenotypes between individuals, affecting safety and efficacy of drugs. Recently, solanidine, a steroidal alkaloid from potatoes, and its metabolites, has been id...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2024-02, Vol.115 (2), p.309-317
Hauptverfasser:	Müller, Julian Peter, Sarömba, Jens, Ziegler, Patrick, Tremmel, Roman, Rengelshausen, Jens, Schaeffeler, Elke, Just, Katja S., Schwab, Matthias, Kraus, Thomas, Stingl, Julia C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism Diosgenin Genotype Humans Metoprolol Phenotype
Online-Zugang:	Volltext
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