IWP‐2 modulates the immunomodulatory properties of human dental pulp stem cells in vitro

Aim To investigate the effect of IWP‐2, Wnt inhibitor, on human dental pulp stem cells (hDPSCs) responses. Methodology hDPSCs were isolated from human dental pulp tissues. Cells were treated with 25 μM IWP‐2 for 24 h, and subsequently, the gene expression profile was examined using high‐throughput R...

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Veröffentlicht in:	International endodontic journal 2024-02, Vol.57 (2), p.219-236
Hauptverfasser:	Chansaenroj, Ajjima, Kornsuthisopon, Chatvadee, Suwittayarak, Ravipha, Rochanavibhata, Sunisa, Loi, Lai‐Keng, Lin, Yu‐Cheng, Osathanon, Thanaphum
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase CD14 antigen CD4 antigen Cell Differentiation Cell Proliferation Cells, Cultured Culture Media, Conditioned - metabolism Culture Media, Conditioned - pharmacology Cytokines Cytokines - metabolism Dental Pulp dental pulp stem cell Down-regulation Gene expression Humans Immunomodulation Immunomodulators Inflammation Lipopolysaccharides Lipopolysaccharides - metabolism Lipopolysaccharides - pharmacology Lymphocytes T Macrophages MAP kinase Monocytes Phosphatidylinositol 3-Kinases - metabolism RNA, Messenger - metabolism Signal transduction Stem Cells Transforming growth factor-b1 Wnt protein Wnt signalling
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