Arsenic-Induced Cardiovascular Diseases and their Correlation with Mitochondrial DNA Copy Number, Deletion, and Telomere Length in Bangladeshi Population
Arsenic contamination is a global health concern, primarily through contaminated groundwater and its entry into the food chain. The association between arsenic exposure and cardiovascular diseases (CVDs) is particularly alarming due to CVDs being the leading cause of death worldwide. Arsenic exposur...
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| Veröffentlicht in: | Cardiovascular toxicology 2024, Vol.24 (1), p.27-40 |
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| creator | Khaleda, Laila Begum, Syeda Kishuara Apu, Md. Abdur Rahman Chowdhury, Rahee Hasan Alam, Md. Jibran Datta, Amit Rahman, Md. Zillur Hosain, Nazmul Al-Forkan, Mohammad |
| description | Arsenic contamination is a global health concern, primarily through contaminated groundwater and its entry into the food chain. The association between arsenic exposure and cardiovascular diseases (CVDs) is particularly alarming due to CVDs being the leading cause of death worldwide. Arsenic exposure has also been linked to changes in telomere length, mitochondrial DNA copy number (mtDNAcn), and deletion, further increasing the risk of CVDs. We aimed to determine whether arsenic exposure alters telomere length and mtDNAcn and deletion in a total of 50 CVD patients who underwent open heart surgery hailed from known arsenic-affected and unaffected areas in Bangladesh. Amount of arsenic was determined from the collected nails and cardiac tissues. Relative telomere length and mtDNAcn and deletion were quantified by qRT-PCR. The patients from arsenic-contaminated areas had higher average arsenic deposits in their fingers and toenails (
P
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| doi_str_mv | 10.1007/s12012-023-09812-7 |
| format | Article |
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P
< 0.05) and higher cardiac tissue injury scores (
P
< 0.05). Moreover, approximately 1.5-fold shorter telomere length (
P
< 0.05,
r
= − 0.775), 1.2-fold decreased mtDNAcn (
P
< 0.05,
r
= − 0.797), and an 81-fold higher amount of mitochondrial DNA deletion (
P
< 0.05,
r
= 0.784) were observed in the patients who had higher arsenic deposition in their nails. Higher levels of arsenic exposure were found to be linked to shorter telomere length, decreased mtDNAcn, and increased mitochondrial DNA deletion in the patients from As-affected areas. It can also be anticipated that the correlation of arsenic exposure with telomere length, mtDNAcn, and deletion can be used as biomarkers for early diagnosis of arsenic-induced cardiovascular diseases.</description><identifier>ISSN: 1530-7905</identifier><identifier>EISSN: 1559-0259</identifier><identifier>DOI: 10.1007/s12012-023-09812-7</identifier><identifier>PMID: 37971645</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Arsenic ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Cardiac patients ; Cardiology ; Cardiovascular diseases ; Contamination ; Copy number ; Deletion ; Ethylenediaminetetraacetic acid ; Exposure ; Food chains ; Food contamination ; Global health ; Groundwater ; Groundwater pollution ; Heart ; Mitochondrial DNA ; Pharmacology/Toxicology ; Public health ; Telomeres ; Water, Underground</subject><ispartof>Cardiovascular toxicology, 2024, Vol.24 (1), p.27-40</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>COPYRIGHT 2024 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-b21f2627f95585e372b1a045000373271da67a9d24eed8e6728f6dc3303776b13</citedby><cites>FETCH-LOGICAL-c442t-b21f2627f95585e372b1a045000373271da67a9d24eed8e6728f6dc3303776b13</cites><orcidid>0000-0002-1331-5875 ; 0000-0002-1100-3181 ; 0000-0002-5044-9274 ; 0000-0002-3228-4912 ; 0009-0000-1155-2722 ; 0000-0002-4284-2447 ; 0000-0002-0128-2965 ; 0000-0003-3222-1118 ; 0000-0001-5031-5607</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12012-023-09812-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12012-023-09812-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37971645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khaleda, Laila</creatorcontrib><creatorcontrib>Begum, Syeda Kishuara</creatorcontrib><creatorcontrib>Apu, Md. Abdur Rahman</creatorcontrib><creatorcontrib>Chowdhury, Rahee Hasan</creatorcontrib><creatorcontrib>Alam, Md. Jibran</creatorcontrib><creatorcontrib>Datta, Amit</creatorcontrib><creatorcontrib>Rahman, Md. Zillur</creatorcontrib><creatorcontrib>Hosain, Nazmul</creatorcontrib><creatorcontrib>Al-Forkan, Mohammad</creatorcontrib><title>Arsenic-Induced Cardiovascular Diseases and their Correlation with Mitochondrial DNA Copy Number, Deletion, and Telomere Length in Bangladeshi Population</title><title>Cardiovascular toxicology</title><addtitle>Cardiovasc Toxicol</addtitle><addtitle>Cardiovasc Toxicol</addtitle><description>Arsenic contamination is a global health concern, primarily through contaminated groundwater and its entry into the food chain. The association between arsenic exposure and cardiovascular diseases (CVDs) is particularly alarming due to CVDs being the leading cause of death worldwide. Arsenic exposure has also been linked to changes in telomere length, mitochondrial DNA copy number (mtDNAcn), and deletion, further increasing the risk of CVDs. We aimed to determine whether arsenic exposure alters telomere length and mtDNAcn and deletion in a total of 50 CVD patients who underwent open heart surgery hailed from known arsenic-affected and unaffected areas in Bangladesh. Amount of arsenic was determined from the collected nails and cardiac tissues. Relative telomere length and mtDNAcn and deletion were quantified by qRT-PCR. The patients from arsenic-contaminated areas had higher average arsenic deposits in their fingers and toenails (
P
< 0.05) and higher cardiac tissue injury scores (
P
< 0.05). Moreover, approximately 1.5-fold shorter telomere length (
P
< 0.05,
r
= − 0.775), 1.2-fold decreased mtDNAcn (
P
< 0.05,
r
= − 0.797), and an 81-fold higher amount of mitochondrial DNA deletion (
P
< 0.05,
r
= 0.784) were observed in the patients who had higher arsenic deposition in their nails. Higher levels of arsenic exposure were found to be linked to shorter telomere length, decreased mtDNAcn, and increased mitochondrial DNA deletion in the patients from As-affected areas. It can also be anticipated that the correlation of arsenic exposure with telomere length, mtDNAcn, and deletion can be used as biomarkers for early diagnosis of arsenic-induced cardiovascular diseases.</description><subject>Arsenic</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cardiac patients</subject><subject>Cardiology</subject><subject>Cardiovascular diseases</subject><subject>Contamination</subject><subject>Copy number</subject><subject>Deletion</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Exposure</subject><subject>Food chains</subject><subject>Food contamination</subject><subject>Global health</subject><subject>Groundwater</subject><subject>Groundwater pollution</subject><subject>Heart</subject><subject>Mitochondrial DNA</subject><subject>Pharmacology/Toxicology</subject><subject>Public health</subject><subject>Telomeres</subject><subject>Water, Underground</subject><issn>1530-7905</issn><issn>1559-0259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9ks9u1DAQxiMEoqXwAhyQJS4cmuI_sZ0cl90ClZbCoZwtrz3ZdeXYi52A-ih9W7xNoQIh5INHM7_v04z0VdVLgs8IxvJtJhQTWmPKaty1pZKPqmPCeVdavHt8qBmuZYf5UfUs52uMKaWCP62OmOwkEQ0_rm4XKUNwpr4IdjJg0VIn6-J3nc3kdUIrl0FnyEgHi8YduISWMSXwenQxoB9u3KFPboxmF4NNTnu0ulwUZH-DLqdhA-kUrcDDAT6987gCHwdIgNYQtkXsAnqnw9ZrC3nn0Je4n2bv59WTXvsML-7_k-rr-_Or5cd6_fnDxXKxrk3T0LHeUNJTQWXfcd5yYJJuiMYNxxgzyagkVgupO0sbANuCkLTthTWMlbEUG8JOqjez7z7FbxPkUQ0uG_BeB4hTVrTtiORctLigr_9Cr-OUQtlOMUJFJ5uO0gdqqz0oF_o4Jm0OpmohW9JggSUv1Nk_qPIsDM7EAL0r_T8EdBaYFHNO0Kt9coNON4pgdciDmvOgSh7UXR6ULKJX9xtPmwHsb8mvABSAzUAuo7CF9HDSf2x_AsdMvqg</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Khaleda, Laila</creator><creator>Begum, Syeda Kishuara</creator><creator>Apu, Md. 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Abdur Rahman ; Chowdhury, Rahee Hasan ; Alam, Md. Jibran ; Datta, Amit ; Rahman, Md. Zillur ; Hosain, Nazmul ; Al-Forkan, Mohammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-b21f2627f95585e372b1a045000373271da67a9d24eed8e6728f6dc3303776b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Arsenic</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cardiac patients</topic><topic>Cardiology</topic><topic>Cardiovascular diseases</topic><topic>Contamination</topic><topic>Copy number</topic><topic>Deletion</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Exposure</topic><topic>Food chains</topic><topic>Food contamination</topic><topic>Global health</topic><topic>Groundwater</topic><topic>Groundwater pollution</topic><topic>Heart</topic><topic>Mitochondrial DNA</topic><topic>Pharmacology/Toxicology</topic><topic>Public health</topic><topic>Telomeres</topic><topic>Water, Underground</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khaleda, Laila</creatorcontrib><creatorcontrib>Begum, Syeda Kishuara</creatorcontrib><creatorcontrib>Apu, Md. 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Abdur Rahman</au><au>Chowdhury, Rahee Hasan</au><au>Alam, Md. Jibran</au><au>Datta, Amit</au><au>Rahman, Md. Zillur</au><au>Hosain, Nazmul</au><au>Al-Forkan, Mohammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arsenic-Induced Cardiovascular Diseases and their Correlation with Mitochondrial DNA Copy Number, Deletion, and Telomere Length in Bangladeshi Population</atitle><jtitle>Cardiovascular toxicology</jtitle><stitle>Cardiovasc Toxicol</stitle><addtitle>Cardiovasc Toxicol</addtitle><date>2024</date><risdate>2024</risdate><volume>24</volume><issue>1</issue><spage>27</spage><epage>40</epage><pages>27-40</pages><issn>1530-7905</issn><eissn>1559-0259</eissn><abstract>Arsenic contamination is a global health concern, primarily through contaminated groundwater and its entry into the food chain. The association between arsenic exposure and cardiovascular diseases (CVDs) is particularly alarming due to CVDs being the leading cause of death worldwide. Arsenic exposure has also been linked to changes in telomere length, mitochondrial DNA copy number (mtDNAcn), and deletion, further increasing the risk of CVDs. We aimed to determine whether arsenic exposure alters telomere length and mtDNAcn and deletion in a total of 50 CVD patients who underwent open heart surgery hailed from known arsenic-affected and unaffected areas in Bangladesh. Amount of arsenic was determined from the collected nails and cardiac tissues. Relative telomere length and mtDNAcn and deletion were quantified by qRT-PCR. The patients from arsenic-contaminated areas had higher average arsenic deposits in their fingers and toenails (
P
< 0.05) and higher cardiac tissue injury scores (
P
< 0.05). Moreover, approximately 1.5-fold shorter telomere length (
P
< 0.05,
r
= − 0.775), 1.2-fold decreased mtDNAcn (
P
< 0.05,
r
= − 0.797), and an 81-fold higher amount of mitochondrial DNA deletion (
P
< 0.05,
r
= 0.784) were observed in the patients who had higher arsenic deposition in their nails. Higher levels of arsenic exposure were found to be linked to shorter telomere length, decreased mtDNAcn, and increased mitochondrial DNA deletion in the patients from As-affected areas. It can also be anticipated that the correlation of arsenic exposure with telomere length, mtDNAcn, and deletion can be used as biomarkers for early diagnosis of arsenic-induced cardiovascular diseases.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>37971645</pmid><doi>10.1007/s12012-023-09812-7</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-1331-5875</orcidid><orcidid>https://orcid.org/0000-0002-1100-3181</orcidid><orcidid>https://orcid.org/0000-0002-5044-9274</orcidid><orcidid>https://orcid.org/0000-0002-3228-4912</orcidid><orcidid>https://orcid.org/0009-0000-1155-2722</orcidid><orcidid>https://orcid.org/0000-0002-4284-2447</orcidid><orcidid>https://orcid.org/0000-0002-0128-2965</orcidid><orcidid>https://orcid.org/0000-0003-3222-1118</orcidid><orcidid>https://orcid.org/0000-0001-5031-5607</orcidid></addata></record> |
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| ispartof | Cardiovascular toxicology, 2024, Vol.24 (1), p.27-40 |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Arsenic Biomarkers Biomedical and Life Sciences Biomedicine Cardiac patients Cardiology Cardiovascular diseases Contamination Copy number Deletion Ethylenediaminetetraacetic acid Exposure Food chains Food contamination Global health Groundwater Groundwater pollution Heart Mitochondrial DNA Pharmacology/Toxicology Public health Telomeres Water, Underground |
| title | Arsenic-Induced Cardiovascular Diseases and their Correlation with Mitochondrial DNA Copy Number, Deletion, and Telomere Length in Bangladeshi Population |
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