Identification of Ebselen derivatives as novel SARS-CoV-2 main protease inhibitors: Design, synthesis, biological evaluation, and structure-activity relationships exploration

The main protease (M ) represents one of the most effective and attractive targets for designing anti-SARS-CoV-2 drugs. In this study, we designed and synthesized a novel series of Ebselen derivatives by incorporating privileged fragments from different pockets of the M active site. Among these comp...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2023-12, Vol.96, p.117531-117531, Article 117531
Hauptverfasser:	Zhang, Heng, Li, Jing, Toth, Karoly, Tollefson, Ann E, Jing, Lanlan, Gao, Shenghua, Liu, Xinyong, Zhan, Peng
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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