Dual targeting of DR5 and VEGFR2 molecular pathways by multivalent fusion protein significantly suppresses tumor growth and angiogenesis

Destroying tumor vasculature is a relevant therapeutic strategy due to its involvement in tumor progression. However, adaptive resistance to approved antiangiogenic drugs targeting VEGF/VEGFR pathway requires the recruitment of additional targets. In this aspect, targeting TRAIL pathway is promising...

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Veröffentlicht in:	International journal of biological macromolecules 2024-01, Vol.255, p.128096-128096, Article 128096
Hauptverfasser:	Isakova, Alina A, Artykov, Artem A, Plotnikova, Ekaterina A, Trunova, Galina V, Khokhlova, Varvara А, Pankratov, Andrey A, Shuvalova, Margarita L, Mazur, Diana V, Antipova, Nadezhda V, Shakhparonov, Mikhail I, Dolgikh, Dmitry A, Kirpichnikov, Mikhail P, Gasparian, Marine E, Yagolovich, Anne V
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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