Association between cytomegalovirus infection and cancer‑related mortality in the US adults
In a nationwide cohort of US adults, an exploration of the association between cytomegalovirus (CMV) infection and cancer‑related mortality was conducted. We acquired data from the National Health and Nutrition Examination Survey III (1988–1994), including 11,138 individuals who were aged 18–90 year...
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| creator | Huang, Xiaoping Yi, Chao Ji, Qianqian Meng, Yaxian Zhang, Aijie Yang, Chongguang Zhou, Liqiong Zhan, Yiqiang |
| description | In a nationwide cohort of US adults, an exploration of the association between cytomegalovirus (CMV) infection and cancer‑related mortality was conducted.
We acquired data from the National Health and Nutrition Examination Survey III (1988–1994), including 11,138 individuals who were aged 18–90 years at enrollment and underwent CMV serology assessments. CMV infection was determined by CMV antibody testing. Cancer‑related mortality status was ascertained until December 2019 utilizing the National Death Index linkage data and determined by neoplasms. The Cox proportional hazard model was applied to estimate the potential association between CMV infection and the risk of cancer-related mortality.
During a median follow-up of 26.1 years, 1514 cancer‑related deaths were identified in the study cohort. After adjusting for age, sex, and ethnicity, CMV infection was associated with a higher hazard of cancer‑related mortality (hazard ratio [HR]: 1.39, 95 % CI: 1.13, 1.70). Further adjustments for body mass index, family income, and smoking status slightly attenuated the magnitude of the association (HR: 1.24, 95 % CI: 1.00, 1.53). However, no significant interaction was observed among gender by subgroup analysis.
CMV infection might be an independent risk factor for cancer‑related mortality among US adults. Future studies could focus on the mechanisms through which CMV infection influences mortality induced by neoplasms and develop targeted interventions to reduce the risk.
•Association between CMV infection and cancer-related mortality.•Data from NHANES III enhance the generalizability and external validity.•Account for several potential confounders and Stratified analysis. |
| doi_str_mv | 10.1016/j.canep.2023.102487 |
| format | Article |
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We acquired data from the National Health and Nutrition Examination Survey III (1988–1994), including 11,138 individuals who were aged 18–90 years at enrollment and underwent CMV serology assessments. CMV infection was determined by CMV antibody testing. Cancer‑related mortality status was ascertained until December 2019 utilizing the National Death Index linkage data and determined by neoplasms. The Cox proportional hazard model was applied to estimate the potential association between CMV infection and the risk of cancer-related mortality.
During a median follow-up of 26.1 years, 1514 cancer‑related deaths were identified in the study cohort. After adjusting for age, sex, and ethnicity, CMV infection was associated with a higher hazard of cancer‑related mortality (hazard ratio [HR]: 1.39, 95 % CI: 1.13, 1.70). Further adjustments for body mass index, family income, and smoking status slightly attenuated the magnitude of the association (HR: 1.24, 95 % CI: 1.00, 1.53). However, no significant interaction was observed among gender by subgroup analysis.
CMV infection might be an independent risk factor for cancer‑related mortality among US adults. Future studies could focus on the mechanisms through which CMV infection influences mortality induced by neoplasms and develop targeted interventions to reduce the risk.
•Association between CMV infection and cancer-related mortality.•Data from NHANES III enhance the generalizability and external validity.•Account for several potential confounders and Stratified analysis.</description><identifier>ISSN: 1877-7821</identifier><identifier>EISSN: 1877-783X</identifier><identifier>DOI: 10.1016/j.canep.2023.102487</identifier><identifier>PMID: 37979224</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adult ; Adults ; Antibodies ; Body mass ; Body mass index ; Body size ; Cancer ; Cancer-related Mortality ; Cytomegalovirus ; Cytomegalovirus Infections - complications ; Cytomegalovirus Infections - epidemiology ; Data acquisition ; Ethnicity ; Family income ; Health hazards ; Health risks ; Hispanic people ; Humans ; Infections ; Medical research ; Minority & ethnic groups ; Mortality ; Neoplasms ; NHANES ; Nutrition Surveys ; Population ; Risk Factors ; Serology ; Smoking ; Statistical models ; Subgroups ; Womens health</subject><ispartof>CANCER EPIDEMIOLOGY, 2023-12, Vol.87, p.102487-102487, Article 102487</ispartof><rights>2023 Elsevier Ltd</rights><rights>Copyright © 2023 Elsevier Ltd. All rights reserved.</rights><rights>2023. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c375t-9bc56c5ba36e877d751c4616017766607450a6ff16df65d27066536241adb9963</cites><orcidid>0000-0002-9950-9055 ; 0000-0001-5815-9725 ; 0009-0002-3203-4208</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1877782123001674$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37979224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:154360640$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Xiaoping</creatorcontrib><creatorcontrib>Yi, Chao</creatorcontrib><creatorcontrib>Ji, Qianqian</creatorcontrib><creatorcontrib>Meng, Yaxian</creatorcontrib><creatorcontrib>Zhang, Aijie</creatorcontrib><creatorcontrib>Yang, Chongguang</creatorcontrib><creatorcontrib>Zhou, Liqiong</creatorcontrib><creatorcontrib>Zhan, Yiqiang</creatorcontrib><title>Association between cytomegalovirus infection and cancer‑related mortality in the US adults</title><title>CANCER EPIDEMIOLOGY</title><addtitle>Cancer Epidemiol</addtitle><description>In a nationwide cohort of US adults, an exploration of the association between cytomegalovirus (CMV) infection and cancer‑related mortality was conducted.
We acquired data from the National Health and Nutrition Examination Survey III (1988–1994), including 11,138 individuals who were aged 18–90 years at enrollment and underwent CMV serology assessments. CMV infection was determined by CMV antibody testing. Cancer‑related mortality status was ascertained until December 2019 utilizing the National Death Index linkage data and determined by neoplasms. The Cox proportional hazard model was applied to estimate the potential association between CMV infection and the risk of cancer-related mortality.
During a median follow-up of 26.1 years, 1514 cancer‑related deaths were identified in the study cohort. After adjusting for age, sex, and ethnicity, CMV infection was associated with a higher hazard of cancer‑related mortality (hazard ratio [HR]: 1.39, 95 % CI: 1.13, 1.70). Further adjustments for body mass index, family income, and smoking status slightly attenuated the magnitude of the association (HR: 1.24, 95 % CI: 1.00, 1.53). However, no significant interaction was observed among gender by subgroup analysis.
CMV infection might be an independent risk factor for cancer‑related mortality among US adults. Future studies could focus on the mechanisms through which CMV infection influences mortality induced by neoplasms and develop targeted interventions to reduce the risk.
•Association between CMV infection and cancer-related mortality.•Data from NHANES III enhance the generalizability and external validity.•Account for several potential confounders and Stratified analysis.</description><subject>Adult</subject><subject>Adults</subject><subject>Antibodies</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Cancer</subject><subject>Cancer-related Mortality</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus Infections - complications</subject><subject>Cytomegalovirus Infections - epidemiology</subject><subject>Data acquisition</subject><subject>Ethnicity</subject><subject>Family income</subject><subject>Health hazards</subject><subject>Health risks</subject><subject>Hispanic people</subject><subject>Humans</subject><subject>Infections</subject><subject>Medical research</subject><subject>Minority & ethnic groups</subject><subject>Mortality</subject><subject>Neoplasms</subject><subject>NHANES</subject><subject>Nutrition Surveys</subject><subject>Population</subject><subject>Risk Factors</subject><subject>Serology</subject><subject>Smoking</subject><subject>Statistical models</subject><subject>Subgroups</subject><subject>Womens health</subject><issn>1877-7821</issn><issn>1877-783X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kctO3DAUhq2qVbm0T4BUReqGTaa-xHayYIEQBSSkLlqkbirLsU-ohyQebAc0O16hr9gnqYcMs2DR1Tk6-s7t_xE6InhBMBFflgujR1gtKKYsV2hVyzdon9RSlrJmP9_uckr20EGMS4yFIIS_R3tMNrKhtNpHv05j9Mbp5PxYtJAeAcbCrJMf4Fb3_sGFKRZu7MA8E3q0Rd5qIPx9-hOg1wlsMfiQdO_SOoNF-g3FzfdC26lP8QN61-k-wsdtPEQ3X89_nF2W198urs5Or0vDJE9l0xouDG81E5BPtpITUwkiMJFSCIFlxbEWXUeE7QS3VOZHOBO0Itq2TSPYISrnufERVlOrVsENOqyV105tS3c5A1Uz3tQ488czvwr-foKY1OCigb7PgvopKlo3RFaNJJvRn1-hSz-FMX-zoSrGpazrTLGZMsHHGKDbnUCw2rillurZLbVxS81u5a5P29lTO4Dd9bzYk4GTGYAs3oODoKJxkOW3LmRHlPXuvwv-Ae3ap4o</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Huang, Xiaoping</creator><creator>Yi, Chao</creator><creator>Ji, Qianqian</creator><creator>Meng, Yaxian</creator><creator>Zhang, Aijie</creator><creator>Yang, Chongguang</creator><creator>Zhou, Liqiong</creator><creator>Zhan, Yiqiang</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><orcidid>https://orcid.org/0000-0002-9950-9055</orcidid><orcidid>https://orcid.org/0000-0001-5815-9725</orcidid><orcidid>https://orcid.org/0009-0002-3203-4208</orcidid></search><sort><creationdate>20231201</creationdate><title>Association between cytomegalovirus infection and cancer‑related mortality in the US adults</title><author>Huang, Xiaoping ; Yi, Chao ; Ji, Qianqian ; Meng, Yaxian ; Zhang, Aijie ; Yang, Chongguang ; Zhou, Liqiong ; Zhan, Yiqiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-9bc56c5ba36e877d751c4616017766607450a6ff16df65d27066536241adb9963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Antibodies</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Cancer</topic><topic>Cancer-related Mortality</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus Infections - 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Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>CANCER EPIDEMIOLOGY</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Xiaoping</au><au>Yi, Chao</au><au>Ji, Qianqian</au><au>Meng, Yaxian</au><au>Zhang, Aijie</au><au>Yang, Chongguang</au><au>Zhou, Liqiong</au><au>Zhan, Yiqiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between cytomegalovirus infection and cancer‑related mortality in the US adults</atitle><jtitle>CANCER EPIDEMIOLOGY</jtitle><addtitle>Cancer Epidemiol</addtitle><date>2023-12-01</date><risdate>2023</risdate><volume>87</volume><spage>102487</spage><epage>102487</epage><pages>102487-102487</pages><artnum>102487</artnum><issn>1877-7821</issn><eissn>1877-783X</eissn><abstract>In a nationwide cohort of US adults, an exploration of the association between cytomegalovirus (CMV) infection and cancer‑related mortality was conducted.
We acquired data from the National Health and Nutrition Examination Survey III (1988–1994), including 11,138 individuals who were aged 18–90 years at enrollment and underwent CMV serology assessments. CMV infection was determined by CMV antibody testing. Cancer‑related mortality status was ascertained until December 2019 utilizing the National Death Index linkage data and determined by neoplasms. The Cox proportional hazard model was applied to estimate the potential association between CMV infection and the risk of cancer-related mortality.
During a median follow-up of 26.1 years, 1514 cancer‑related deaths were identified in the study cohort. After adjusting for age, sex, and ethnicity, CMV infection was associated with a higher hazard of cancer‑related mortality (hazard ratio [HR]: 1.39, 95 % CI: 1.13, 1.70). Further adjustments for body mass index, family income, and smoking status slightly attenuated the magnitude of the association (HR: 1.24, 95 % CI: 1.00, 1.53). However, no significant interaction was observed among gender by subgroup analysis.
CMV infection might be an independent risk factor for cancer‑related mortality among US adults. Future studies could focus on the mechanisms through which CMV infection influences mortality induced by neoplasms and develop targeted interventions to reduce the risk.
•Association between CMV infection and cancer-related mortality.•Data from NHANES III enhance the generalizability and external validity.•Account for several potential confounders and Stratified analysis.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>37979224</pmid><doi>10.1016/j.canep.2023.102487</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-9950-9055</orcidid><orcidid>https://orcid.org/0000-0001-5815-9725</orcidid><orcidid>https://orcid.org/0009-0002-3203-4208</orcidid></addata></record> |
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| subjects | Adult Adults Antibodies Body mass Body mass index Body size Cancer Cancer-related Mortality Cytomegalovirus Cytomegalovirus Infections - complications Cytomegalovirus Infections - epidemiology Data acquisition Ethnicity Family income Health hazards Health risks Hispanic people Humans Infections Medical research Minority & ethnic groups Mortality Neoplasms NHANES Nutrition Surveys Population Risk Factors Serology Smoking Statistical models Subgroups Womens health |
| title | Association between cytomegalovirus infection and cancer‑related mortality in the US adults |
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