The significance of mitochondrial haplogroups in preeclampsia risk
OBJECTIVETo determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model.METHODSThis retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-ti...
Gespeichert in:
| Veröffentlicht in: | Pregnancy hypertension 2023-12, Vol.34, p.146-151 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 151 |
|---|---|
| container_issue | |
| container_start_page | 146 |
| container_title | Pregnancy hypertension |
| container_volume | 34 |
| creator | Wendelboe Olsen, Kristina Hedley, Paula L. Hagen, Christian M. Rode, Line Placing, Sophie Wøjdemann, Karen R. Shalmi, Anne-Cathrine Sundberg, Karin Nørremølle, Anne Tabor, Ann Elson, Joanna L. Christiansen, Michael |
| description | OBJECTIVETo determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model.METHODSThis retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-time PCR or Sanger sequencing depending on the rarity of the haplogroup.RESULTSNo significant association between haplogroups and the risk of preeclampsia was found, nor was any role for haplogroups in disease severity uncovered.CONCLUSIONMitochondrial haplogroups are not associated with preeclampsia or the severity of preeclampsia in the Danish population. However, this study cannot exclude a role for less common mtDNA variation. Models that can examine these should be applied in preeclamptic patients. |
| doi_str_mv | 10.1016/j.preghy.2023.11.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2891748544</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2891748544</sourcerecordid><originalsourceid>FETCH-LOGICAL-c279t-b28267bed6f52f4aea253fa9799902ade536a37b105e2d61e9585a4b95097c53</originalsourceid><addsrcrecordid>eNo9kDFPwzAUhC0EElXpP2DIyJJgO3Ycj1ABRarE0t16cZ4blyQOdjv035OqiFvuhtOd9BHyyGjBKKueD8UUcd-dC055WTBWUMpuyIJzRnOltLr9z7W-J6uUDnSWkLRW1YK87jrMkt-P3nkLo8UsuGzwx2C7MLbRQ591MPVhH8NpSpkfs_kNbQ_DlDxk0afvB3LnoE-4-vMl2b2_7dabfPv18bl-2eaWK33MG17zSjXYVk5yJwCBy9KBVlpryqFFWVZQqoZRibytGGpZSxCNllQrK8slebrOTjH8nDAdzeCTxb6HEcMpGV5rpkQthZir4lq1MaQU0Zkp-gHi2TBqLtDMwVyhmQs0w5iZoZW_eZxiFQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2891748544</pqid></control><display><type>article</type><title>The significance of mitochondrial haplogroups in preeclampsia risk</title><source>Elsevier ScienceDirect Journals</source><creator>Wendelboe Olsen, Kristina ; Hedley, Paula L. ; Hagen, Christian M. ; Rode, Line ; Placing, Sophie ; Wøjdemann, Karen R. ; Shalmi, Anne-Cathrine ; Sundberg, Karin ; Nørremølle, Anne ; Tabor, Ann ; Elson, Joanna L. ; Christiansen, Michael</creator><creatorcontrib>Wendelboe Olsen, Kristina ; Hedley, Paula L. ; Hagen, Christian M. ; Rode, Line ; Placing, Sophie ; Wøjdemann, Karen R. ; Shalmi, Anne-Cathrine ; Sundberg, Karin ; Nørremølle, Anne ; Tabor, Ann ; Elson, Joanna L. ; Christiansen, Michael</creatorcontrib><description>OBJECTIVETo determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model.METHODSThis retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-time PCR or Sanger sequencing depending on the rarity of the haplogroup.RESULTSNo significant association between haplogroups and the risk of preeclampsia was found, nor was any role for haplogroups in disease severity uncovered.CONCLUSIONMitochondrial haplogroups are not associated with preeclampsia or the severity of preeclampsia in the Danish population. However, this study cannot exclude a role for less common mtDNA variation. Models that can examine these should be applied in preeclamptic patients.</description><identifier>ISSN: 2210-7789</identifier><identifier>EISSN: 2210-7797</identifier><identifier>DOI: 10.1016/j.preghy.2023.11.001</identifier><language>eng</language><ispartof>Pregnancy hypertension, 2023-12, Vol.34, p.146-151</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c279t-b28267bed6f52f4aea253fa9799902ade536a37b105e2d61e9585a4b95097c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Wendelboe Olsen, Kristina</creatorcontrib><creatorcontrib>Hedley, Paula L.</creatorcontrib><creatorcontrib>Hagen, Christian M.</creatorcontrib><creatorcontrib>Rode, Line</creatorcontrib><creatorcontrib>Placing, Sophie</creatorcontrib><creatorcontrib>Wøjdemann, Karen R.</creatorcontrib><creatorcontrib>Shalmi, Anne-Cathrine</creatorcontrib><creatorcontrib>Sundberg, Karin</creatorcontrib><creatorcontrib>Nørremølle, Anne</creatorcontrib><creatorcontrib>Tabor, Ann</creatorcontrib><creatorcontrib>Elson, Joanna L.</creatorcontrib><creatorcontrib>Christiansen, Michael</creatorcontrib><title>The significance of mitochondrial haplogroups in preeclampsia risk</title><title>Pregnancy hypertension</title><description>OBJECTIVETo determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model.METHODSThis retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-time PCR or Sanger sequencing depending on the rarity of the haplogroup.RESULTSNo significant association between haplogroups and the risk of preeclampsia was found, nor was any role for haplogroups in disease severity uncovered.CONCLUSIONMitochondrial haplogroups are not associated with preeclampsia or the severity of preeclampsia in the Danish population. However, this study cannot exclude a role for less common mtDNA variation. Models that can examine these should be applied in preeclamptic patients.</description><issn>2210-7789</issn><issn>2210-7797</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNo9kDFPwzAUhC0EElXpP2DIyJJgO3Ycj1ABRarE0t16cZ4blyQOdjv035OqiFvuhtOd9BHyyGjBKKueD8UUcd-dC055WTBWUMpuyIJzRnOltLr9z7W-J6uUDnSWkLRW1YK87jrMkt-P3nkLo8UsuGzwx2C7MLbRQ591MPVhH8NpSpkfs_kNbQ_DlDxk0afvB3LnoE-4-vMl2b2_7dabfPv18bl-2eaWK33MG17zSjXYVk5yJwCBy9KBVlpryqFFWVZQqoZRibytGGpZSxCNllQrK8slebrOTjH8nDAdzeCTxb6HEcMpGV5rpkQthZir4lq1MaQU0Zkp-gHi2TBqLtDMwVyhmQs0w5iZoZW_eZxiFQ</recordid><startdate>202312</startdate><enddate>202312</enddate><creator>Wendelboe Olsen, Kristina</creator><creator>Hedley, Paula L.</creator><creator>Hagen, Christian M.</creator><creator>Rode, Line</creator><creator>Placing, Sophie</creator><creator>Wøjdemann, Karen R.</creator><creator>Shalmi, Anne-Cathrine</creator><creator>Sundberg, Karin</creator><creator>Nørremølle, Anne</creator><creator>Tabor, Ann</creator><creator>Elson, Joanna L.</creator><creator>Christiansen, Michael</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202312</creationdate><title>The significance of mitochondrial haplogroups in preeclampsia risk</title><author>Wendelboe Olsen, Kristina ; Hedley, Paula L. ; Hagen, Christian M. ; Rode, Line ; Placing, Sophie ; Wøjdemann, Karen R. ; Shalmi, Anne-Cathrine ; Sundberg, Karin ; Nørremølle, Anne ; Tabor, Ann ; Elson, Joanna L. ; Christiansen, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c279t-b28267bed6f52f4aea253fa9799902ade536a37b105e2d61e9585a4b95097c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Wendelboe Olsen, Kristina</creatorcontrib><creatorcontrib>Hedley, Paula L.</creatorcontrib><creatorcontrib>Hagen, Christian M.</creatorcontrib><creatorcontrib>Rode, Line</creatorcontrib><creatorcontrib>Placing, Sophie</creatorcontrib><creatorcontrib>Wøjdemann, Karen R.</creatorcontrib><creatorcontrib>Shalmi, Anne-Cathrine</creatorcontrib><creatorcontrib>Sundberg, Karin</creatorcontrib><creatorcontrib>Nørremølle, Anne</creatorcontrib><creatorcontrib>Tabor, Ann</creatorcontrib><creatorcontrib>Elson, Joanna L.</creatorcontrib><creatorcontrib>Christiansen, Michael</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pregnancy hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wendelboe Olsen, Kristina</au><au>Hedley, Paula L.</au><au>Hagen, Christian M.</au><au>Rode, Line</au><au>Placing, Sophie</au><au>Wøjdemann, Karen R.</au><au>Shalmi, Anne-Cathrine</au><au>Sundberg, Karin</au><au>Nørremølle, Anne</au><au>Tabor, Ann</au><au>Elson, Joanna L.</au><au>Christiansen, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The significance of mitochondrial haplogroups in preeclampsia risk</atitle><jtitle>Pregnancy hypertension</jtitle><date>2023-12</date><risdate>2023</risdate><volume>34</volume><spage>146</spage><epage>151</epage><pages>146-151</pages><issn>2210-7789</issn><eissn>2210-7797</eissn><abstract>OBJECTIVETo determine whether mitochondrial haplogroups function as disease-modifiers or as susceptibility factors in preeclampsia using a traditional haplogroup association model.METHODSThis retrospective study haplotyped 235 control and 78 preeclamptic pregnancies from Denmark using either real-time PCR or Sanger sequencing depending on the rarity of the haplogroup.RESULTSNo significant association between haplogroups and the risk of preeclampsia was found, nor was any role for haplogroups in disease severity uncovered.CONCLUSIONMitochondrial haplogroups are not associated with preeclampsia or the severity of preeclampsia in the Danish population. However, this study cannot exclude a role for less common mtDNA variation. Models that can examine these should be applied in preeclamptic patients.</abstract><doi>10.1016/j.preghy.2023.11.001</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2210-7789 |
| ispartof | Pregnancy hypertension, 2023-12, Vol.34, p.146-151 |
| issn | 2210-7789 2210-7797 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2891748544 |
| source | Elsevier ScienceDirect Journals |
| title | The significance of mitochondrial haplogroups in preeclampsia risk |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T02%3A12%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20significance%20of%20mitochondrial%20haplogroups%20in%20preeclampsia%20risk&rft.jtitle=Pregnancy%20hypertension&rft.au=Wendelboe%20Olsen,%20Kristina&rft.date=2023-12&rft.volume=34&rft.spage=146&rft.epage=151&rft.pages=146-151&rft.issn=2210-7789&rft.eissn=2210-7797&rft_id=info:doi/10.1016/j.preghy.2023.11.001&rft_dat=%3Cproquest_cross%3E2891748544%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2891748544&rft_id=info:pmid/&rfr_iscdi=true |