Erythropoietin improves pulmonary hypertension by promoting the homing and differentiation of bone marrow mesenchymal stem cells in lung tissue
Pulmonary arterial hypertension (PAH) is a chronic disease thatultimately progresses to right-sided heart failure and death. Erythropoietin (EPO) has been shown to have therapeutic potential in cardiovascular diseases, including PAH. In this study, we aimed to investigate the improvement effect of E...
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| Veröffentlicht in: | Human cell : official journal of Human Cell Research Society 2024-01, Vol.37 (1), p.214-228 |
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| creator | Zhong, Zhendong Li, Kang Shen, Chongyang Ma, Yuxiao Guo, Lu |
| description | Pulmonary arterial hypertension (PAH) is a chronic disease thatultimately progresses to right-sided heart failure and death. Erythropoietin (EPO) has been shown to have therapeutic potential in cardiovascular diseases, including PAH. In this study, we aimed to investigate the improvement effect of EPO pretreated bone marrow mesenchymal stem cells (BMSCs) on PAH. BMSCs were obtained from the bone marrow of male SD rats. Female rats were randomly divided into six groups, including control group, monocrotaline (MCT)-induced group, and four groups with different doses of EPO pretreated BMSCs. Lung tissue was taken for testing at 2 weeks of treatment. Our results showed EPO promoted homing and endothelial cell differentiation of BMSCs in the lung tissues of PAH rats. EPO and BMSCs treatment attenuated pulmonary arterial pressure, polycythemia, and pulmonary artery structural remodeling. Furthermore, BMSCs inhibited pulmonary vascular endothelial-to-mesenchymal transition (EndoMT) in PAH rats, which was further suppressed by EPO in a concentration-dependent manner. Meanwhile, EPO and BMSC treatment elevated pulmonary angiogenesis in PAH rats. BMSCs inhibited TNF-α, IL-1β, IL-6, and MCP-1 in lung tissues of PAH rats, which was further decreased by EPO in a concentration-dependent manner. Thus, EPO improved pulmonary hypertension (PH) by promoting the homing and differentiation of BMSCs in lung tissue. |
| doi_str_mv | 10.1007/s13577-023-01009-y |
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Erythropoietin (EPO) has been shown to have therapeutic potential in cardiovascular diseases, including PAH. In this study, we aimed to investigate the improvement effect of EPO pretreated bone marrow mesenchymal stem cells (BMSCs) on PAH. BMSCs were obtained from the bone marrow of male SD rats. Female rats were randomly divided into six groups, including control group, monocrotaline (MCT)-induced group, and four groups with different doses of EPO pretreated BMSCs. Lung tissue was taken for testing at 2 weeks of treatment. Our results showed EPO promoted homing and endothelial cell differentiation of BMSCs in the lung tissues of PAH rats. EPO and BMSCs treatment attenuated pulmonary arterial pressure, polycythemia, and pulmonary artery structural remodeling. Furthermore, BMSCs inhibited pulmonary vascular endothelial-to-mesenchymal transition (EndoMT) in PAH rats, which was further suppressed by EPO in a concentration-dependent manner. Meanwhile, EPO and BMSC treatment elevated pulmonary angiogenesis in PAH rats. BMSCs inhibited TNF-α, IL-1β, IL-6, and MCP-1 in lung tissues of PAH rats, which was further decreased by EPO in a concentration-dependent manner. Thus, EPO improved pulmonary hypertension (PH) by promoting the homing and differentiation of BMSCs in lung tissue.</description><identifier>ISSN: 1749-0774</identifier><identifier>ISSN: 0914-7470</identifier><identifier>EISSN: 1749-0774</identifier><identifier>DOI: 10.1007/s13577-023-01009-y</identifier><identifier>PMID: 37968533</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Angiogenesis ; Animals ; Biomedical and Life Sciences ; Blood pressure ; Bone marrow ; Bone Marrow Cells ; Cardiovascular diseases ; Cell Biology ; Cell Differentiation ; Congestive heart failure ; Endothelial cells ; Erythropoietin ; Erythropoietin - pharmacology ; Female ; Gynecology ; Hypertension ; Hypertension, Pulmonary - chemically induced ; Hypertension, Pulmonary - therapy ; Life Sciences ; Lung ; Lungs ; Male ; Mesenchymal Stem Cell Transplantation - methods ; Mesenchymal Stem Cells ; Monocrotaline ; Monocyte chemoattractant protein 1 ; Oncology ; Polycythemia ; Pulmonary arteries ; Pulmonary artery ; Pulmonary hypertension ; Rats ; Rats, Sprague-Dawley ; Reproductive Medicine ; Research Article ; Stem Cells ; Surgery ; Tumor necrosis factor-α ; Vascular Remodeling</subject><ispartof>Human cell : official journal of Human Cell Research Society, 2024-01, Vol.37 (1), p.214-228</ispartof><rights>The Author(s) under exclusive licence to Japan Human Cell Society 2023. 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Erythropoietin (EPO) has been shown to have therapeutic potential in cardiovascular diseases, including PAH. In this study, we aimed to investigate the improvement effect of EPO pretreated bone marrow mesenchymal stem cells (BMSCs) on PAH. BMSCs were obtained from the bone marrow of male SD rats. Female rats were randomly divided into six groups, including control group, monocrotaline (MCT)-induced group, and four groups with different doses of EPO pretreated BMSCs. Lung tissue was taken for testing at 2 weeks of treatment. Our results showed EPO promoted homing and endothelial cell differentiation of BMSCs in the lung tissues of PAH rats. EPO and BMSCs treatment attenuated pulmonary arterial pressure, polycythemia, and pulmonary artery structural remodeling. Furthermore, BMSCs inhibited pulmonary vascular endothelial-to-mesenchymal transition (EndoMT) in PAH rats, which was further suppressed by EPO in a concentration-dependent manner. Meanwhile, EPO and BMSC treatment elevated pulmonary angiogenesis in PAH rats. BMSCs inhibited TNF-α, IL-1β, IL-6, and MCP-1 in lung tissues of PAH rats, which was further decreased by EPO in a concentration-dependent manner. Thus, EPO improved pulmonary hypertension (PH) by promoting the homing and differentiation of BMSCs in lung tissue.</description><subject>Angiogenesis</subject><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Blood pressure</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells</subject><subject>Cardiovascular diseases</subject><subject>Cell Biology</subject><subject>Cell Differentiation</subject><subject>Congestive heart failure</subject><subject>Endothelial cells</subject><subject>Erythropoietin</subject><subject>Erythropoietin - pharmacology</subject><subject>Female</subject><subject>Gynecology</subject><subject>Hypertension</subject><subject>Hypertension, Pulmonary - chemically induced</subject><subject>Hypertension, Pulmonary - therapy</subject><subject>Life Sciences</subject><subject>Lung</subject><subject>Lungs</subject><subject>Male</subject><subject>Mesenchymal Stem Cell Transplantation - methods</subject><subject>Mesenchymal Stem Cells</subject><subject>Monocrotaline</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Oncology</subject><subject>Polycythemia</subject><subject>Pulmonary arteries</subject><subject>Pulmonary artery</subject><subject>Pulmonary hypertension</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reproductive Medicine</subject><subject>Research Article</subject><subject>Stem Cells</subject><subject>Surgery</subject><subject>Tumor necrosis factor-α</subject><subject>Vascular Remodeling</subject><issn>1749-0774</issn><issn>0914-7470</issn><issn>1749-0774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1zAMxiMEYmPwBTigSFy4FNKkbZojmsaLNIkLnKO0ddZMTVLiFNRPsa9Myn-8iAMnW_bPj209hDyv2euaMfkGa9FKWTEuKlYKqtofkPNaNqpiUjYP_8rPyBPEW8aatun4Y3ImpOr6VohzcneV9jynuEYH2QXq_JriN0C6bouPwaSdzvsKKUNAFwMddloAHwt7Q_MMdI7-SE2Y6OSshQQhO5MPNlo6xADUm5Tid-oBIYzz7s1CMYOnIywL0rJ02Q4xh7jBU_LImgXh2X28IF_eXX2-_FBdf3r_8fLtdTUK3uWKK9NyLttagQTZCGkZN3aynA8cOFO8U7K3cuwnBsa2XICaBsVAjH1vp2EUF-TVSbd883UDzNo7PA4yAeKGmveKybaVTV_Ql_-gt3FLoVynuWKq65SQvFD8RI0pIiawek2ufL7rmunDLn2ySxe79E-79F6GXtxLb4OH6ffIL38KIE4Alla4gfRn939kfwD0JKTn</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Zhong, Zhendong</creator><creator>Li, Kang</creator><creator>Shen, Chongyang</creator><creator>Ma, Yuxiao</creator><creator>Guo, Lu</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240101</creationdate><title>Erythropoietin improves pulmonary hypertension by promoting the homing and differentiation of bone marrow mesenchymal stem cells in lung tissue</title><author>Zhong, Zhendong ; Li, Kang ; Shen, Chongyang ; Ma, Yuxiao ; Guo, Lu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-29a5227519e7e7437f02afdf22b2e20926978f7c8d0eaf523e9db90e3c88fdbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Angiogenesis</topic><topic>Animals</topic><topic>Biomedical and Life Sciences</topic><topic>Blood pressure</topic><topic>Bone marrow</topic><topic>Bone Marrow Cells</topic><topic>Cardiovascular diseases</topic><topic>Cell Biology</topic><topic>Cell Differentiation</topic><topic>Congestive heart failure</topic><topic>Endothelial cells</topic><topic>Erythropoietin</topic><topic>Erythropoietin - pharmacology</topic><topic>Female</topic><topic>Gynecology</topic><topic>Hypertension</topic><topic>Hypertension, Pulmonary - chemically induced</topic><topic>Hypertension, Pulmonary - therapy</topic><topic>Life Sciences</topic><topic>Lung</topic><topic>Lungs</topic><topic>Male</topic><topic>Mesenchymal Stem Cell Transplantation - methods</topic><topic>Mesenchymal Stem Cells</topic><topic>Monocrotaline</topic><topic>Monocyte chemoattractant protein 1</topic><topic>Oncology</topic><topic>Polycythemia</topic><topic>Pulmonary arteries</topic><topic>Pulmonary artery</topic><topic>Pulmonary hypertension</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reproductive Medicine</topic><topic>Research Article</topic><topic>Stem Cells</topic><topic>Surgery</topic><topic>Tumor necrosis factor-α</topic><topic>Vascular Remodeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhong, Zhendong</creatorcontrib><creatorcontrib>Li, Kang</creatorcontrib><creatorcontrib>Shen, Chongyang</creatorcontrib><creatorcontrib>Ma, Yuxiao</creatorcontrib><creatorcontrib>Guo, Lu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human cell : official journal of Human Cell Research Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhong, Zhendong</au><au>Li, Kang</au><au>Shen, Chongyang</au><au>Ma, Yuxiao</au><au>Guo, Lu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Erythropoietin improves pulmonary hypertension by promoting the homing and differentiation of bone marrow mesenchymal stem cells in lung tissue</atitle><jtitle>Human cell : official journal of Human Cell Research Society</jtitle><stitle>Human Cell</stitle><addtitle>Hum Cell</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>37</volume><issue>1</issue><spage>214</spage><epage>228</epage><pages>214-228</pages><issn>1749-0774</issn><issn>0914-7470</issn><eissn>1749-0774</eissn><abstract>Pulmonary arterial hypertension (PAH) is a chronic disease thatultimately progresses to right-sided heart failure and death. Erythropoietin (EPO) has been shown to have therapeutic potential in cardiovascular diseases, including PAH. In this study, we aimed to investigate the improvement effect of EPO pretreated bone marrow mesenchymal stem cells (BMSCs) on PAH. BMSCs were obtained from the bone marrow of male SD rats. Female rats were randomly divided into six groups, including control group, monocrotaline (MCT)-induced group, and four groups with different doses of EPO pretreated BMSCs. Lung tissue was taken for testing at 2 weeks of treatment. Our results showed EPO promoted homing and endothelial cell differentiation of BMSCs in the lung tissues of PAH rats. EPO and BMSCs treatment attenuated pulmonary arterial pressure, polycythemia, and pulmonary artery structural remodeling. Furthermore, BMSCs inhibited pulmonary vascular endothelial-to-mesenchymal transition (EndoMT) in PAH rats, which was further suppressed by EPO in a concentration-dependent manner. Meanwhile, EPO and BMSC treatment elevated pulmonary angiogenesis in PAH rats. BMSCs inhibited TNF-α, IL-1β, IL-6, and MCP-1 in lung tissues of PAH rats, which was further decreased by EPO in a concentration-dependent manner. Thus, EPO improved pulmonary hypertension (PH) by promoting the homing and differentiation of BMSCs in lung tissue.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>37968533</pmid><doi>10.1007/s13577-023-01009-y</doi><tpages>15</tpages></addata></record> |
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| subjects | Angiogenesis Animals Biomedical and Life Sciences Blood pressure Bone marrow Bone Marrow Cells Cardiovascular diseases Cell Biology Cell Differentiation Congestive heart failure Endothelial cells Erythropoietin Erythropoietin - pharmacology Female Gynecology Hypertension Hypertension, Pulmonary - chemically induced Hypertension, Pulmonary - therapy Life Sciences Lung Lungs Male Mesenchymal Stem Cell Transplantation - methods Mesenchymal Stem Cells Monocrotaline Monocyte chemoattractant protein 1 Oncology Polycythemia Pulmonary arteries Pulmonary artery Pulmonary hypertension Rats Rats, Sprague-Dawley Reproductive Medicine Research Article Stem Cells Surgery Tumor necrosis factor-α Vascular Remodeling |
| title | Erythropoietin improves pulmonary hypertension by promoting the homing and differentiation of bone marrow mesenchymal stem cells in lung tissue |
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