Is compressed colchicine tablet superior to other colchicine preparations in patients with familial Mediterranean fever?

Is compressed colchicine tablet superior to other colchicine preparations in patients with familial Mediterranean fever?

The aim of our study is to evaluate the differences in effectiveness, dosage, and side effect profiles in the use of colchicine preparations and evaluate the superiority of compressed colchicine tablets in familial Mediterranean fever (FMF) patients with resistance or intolerance to coated colchicin...

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Veröffentlicht in:International journal of clinical pharmacology and therapeutics 2024-02, Vol.62 (2), p.77-82
Hauptverfasser: Vasi, İbrahim, Kardaş, Rıza Can, Yıldırım, Derya, Kaya, Burcugül, Duran, Rahime, Karadeniz, Hazan, Avanoğlu Güler, Aslıhan, Erden, Abdulsamet, Küçük, Hamit, Göker, Berna, Tufan, Abdurrahman, Öztürk, Mehmet Akif
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container_end_page 82
container_issue 2
container_start_page 77
container_title International journal of clinical pharmacology and therapeutics
container_volume 62
creator Vasi, İbrahim
Kardaş, Rıza Can
Yıldırım, Derya
Kaya, Burcugül
Duran, Rahime
Karadeniz, Hazan
Avanoğlu Güler, Aslıhan
Erden, Abdulsamet
Küçük, Hamit
Göker, Berna
Tufan, Abdurrahman
Öztürk, Mehmet Akif
description The aim of our study is to evaluate the differences in effectiveness, dosage, and side effect profiles in the use of colchicine preparations and evaluate the superiority of compressed colchicine tablets in familial Mediterranean fever (FMF) patients with resistance or intolerance to coated colchicine tablets. Patients who were diagnosed with FMF according to the Tel Hashomer criteria, aged 18 years and older, and switched from compressed colchicine to coated colchicine tablets in the rheumatology clinic of Gazi University were identified. The daily colchicine dose and FMF attack frequency before and after switching from coated colchicine tablets to compressed colchicine tablets were compared. The study included 43 female (72.9%) and 16 male patients (27.1%), and the mean age was 34.54 ± 8.3 years. The number of attacks per year was significantly reduced after switching to compressed colchicine tablets, and daily colchicine doses were lower after switching to compressed colchicine tablets (1.97 ± 0.23 vs 1.78 ± 0.39 mg, p 
doi_str_mv 10.5414/CP204494
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Patients who were diagnosed with FMF according to the Tel Hashomer criteria, aged 18 years and older, and switched from compressed colchicine to coated colchicine tablets in the rheumatology clinic of Gazi University were identified. The daily colchicine dose and FMF attack frequency before and after switching from coated colchicine tablets to compressed colchicine tablets were compared. The study included 43 female (72.9%) and 16 male patients (27.1%), and the mean age was 34.54 ± 8.3 years. The number of attacks per year was significantly reduced after switching to compressed colchicine tablets, and daily colchicine doses were lower after switching to compressed colchicine tablets (1.97 ± 0.23 vs 1.78 ± 0.39 mg, p &lt; 0.001). 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Patients who were diagnosed with FMF according to the Tel Hashomer criteria, aged 18 years and older, and switched from compressed colchicine to coated colchicine tablets in the rheumatology clinic of Gazi University were identified. The daily colchicine dose and FMF attack frequency before and after switching from coated colchicine tablets to compressed colchicine tablets were compared. The study included 43 female (72.9%) and 16 male patients (27.1%), and the mean age was 34.54 ± 8.3 years. The number of attacks per year was significantly reduced after switching to compressed colchicine tablets, and daily colchicine doses were lower after switching to compressed colchicine tablets (1.97 ± 0.23 vs 1.78 ± 0.39 mg, p &lt; 0.001). 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title Is compressed colchicine tablet superior to other colchicine preparations in patients with familial Mediterranean fever?
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