A phenotypic screening platform for chronic pain therapeutics using all-optical electrophysiology

Chronic pain associated with osteoarthritis (OA) remains an intractable problem with few effective treatment options. New approaches are needed to model the disease biology and to drive discovery of therapeutics. We present an in vitro model of OA pain, where dorsal root ganglion (DRG) sensory neuro...

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Veröffentlicht in:	Pain (Amsterdam) 2024-04, Vol.165 (4), p.922-940
Hauptverfasser:	Liu, Pin W, Zhang, Hongkang, Werley, Christopher A, Pichler, Monika, Ryan, Steven J, Lewarch, Caitlin L, Jacques, Jane, Grooms, Jennifer, Ferrante, Jean, Li, Guangde, Zhang, Dawei, Bremmer, Nate, Barnett, Adam, Chantre, Romina, Elder, Amy E, Cohen, Adam E, Williams, Luis A, Dempsey, Graham T, McManus, Owen B
Format:	Artikel
Sprache:	eng
Schlagworte:	Chronic Pain - complications Electrophysiology Ganglia, Spinal - metabolism Humans Inflammation Mediators - metabolism Mitogen-Activated Protein Kinase Kinases - metabolism Osteoarthritis - complications Sensory Receptor Cells - physiology
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