Dynamics and durability of HIV-1 neutralization are determined by viral replication

Human immunodeficiency virus type 1 (HIV-1)-neutralizing antibodies (nAbs) that prevent infection are the main goal of HIV vaccine discovery. But as no nAb-eliciting vaccines are yet available, only data from HIV-1 neutralizers—persons with HIV-1 who naturally develop broad and potent nAbs—can infor...

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Veröffentlicht in:	Nature medicine 2023-11, Vol.29 (11), p.2763-2774
Hauptverfasser:	Schommers, Philipp, Kim, Dae Sung, Schlotz, Maike, Kreer, Christoph, Eggeling, Ralf, Hake, Anna, Stecher, Melanie, Park, Juyeon, Radford, Caelan E., Dingens, Adam S., Ercanoglu, Meryem S., Gruell, Henning, Odidika, Stanley, Dahlhaus, Marten, Gieselmann, Lutz, Ahmadov, Elvin, Lawong, Rene Y., Heger, Eva, Knops, Elena, Wyen, Christoph, Kümmerle, Tim, Römer, Katja, Scholten, Stefan, Wolf, Timo, Stephan, Christoph, Suárez, Isabelle, Raju, Nagarajan, Adhikari, Anurag, Esser, Stefan, Streeck, Hendrik, Duerr, Ralf, Nanfack, Aubin J., Zolla-Pazner, Susan, Geldmacher, Christof, Geisenberger, Otto, Kroidl, Arne, William, Wiston, Maganga, Lucas, Ntinginya, Nyanda Elias, Georgiev, Ivelin S., Vehreschild, Jörg J., Hoelscher, Michael, Fätkenheuer, Gerd, Lavinder, Jason J., Bloom, Jesse D., Seaman, Michael S., Lehmann, Clara, Pfeifer, Nico, Georgiou, George, Klein, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/254 631/250/255/1901 692/699/255/1901 AIDS Vaccines Antibodies, Neutralizing Antibody response Antigens Antiretroviral agents Antiretroviral therapy Biomedical and Life Sciences Biomedicine Cancer Research CD4 antigen Durability HIV HIV Antibodies HIV Infections HIV-1 Human immunodeficiency virus Humans IgG antibody Immune system Immunoglobulin G Immunological memory Infectious Diseases Lymphocytes Lymphocytes B Lymphocytes T Memory cells Metabolic Diseases Molecular Medicine Neurosciences Neutralization Neutralizers Neutralizing Vaccines Viremia Virus Replication Viruses
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